UBE2D2 and RAF1

Number of citations of the paper that reports this interaction (PMID 11676916)
56

Data Source:
BioGRID (enzymatic study)

		UBE2D2	RAF1
Gene Name		ubiquitin-conjugating enzyme E2D 2	Raf-1 proto-oncogene, serine/threonine kinase
Image
Gene Ontology Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleoplasm Cytosol Protein Complex Extracellular Vesicular Exosome	Nucleus Cytoplasm Mitochondrial Outer Membrane Golgi Apparatus Cytosol Plasma Membrane Pseudopodium
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ligase Activity Ubiquitin Conjugating Enzyme Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding Small GTPase Binding Mitogen-activated Protein Kinase Kinase Binding Identical Protein Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Protein Polyubiquitination Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Innate Immune Response Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Protein K48-linked Ubiquitination Cellular Response To Hypoxia	MAPK Cascade Activation Of MAPKK Activity Response To Hypoxia Protein Phosphorylation Apoptotic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Synaptic Transmission Axon Guidance Heart Development Blood Coagulation Cell Proliferation Negative Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Platelet Activation Negative Regulation Of Protein Complex Assembly Positive Regulation Of Peptidyl-serine Phosphorylation Ion Transmembrane Transport Somatic Stem Cell Maintenance Regulation Of Rho Protein Signal Transduction Fc-epsilon Receptor Signaling Pathway Wound Healing Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Intermediate Filament Cytoskeleton Organization Regulation Of Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Transmembrane Transport Death-inducing Signaling Complex Assembly Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Cell Motility
Pathways		Cellular response to hypoxia Regulation of Hypoxia-inducible Factor (HIF) by oxygen Antigen processing: Ubiquitination & Proteasome degradation Negative regulators of RIG-I/MDA5 signaling Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha IKK complex recruitment mediated by RIP1 TRIF-mediated TLR3/TLR4 signaling MyD88-independent cascade Activated TLR4 signalling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Toll Like Receptor 3 (TLR3) Cascade Class I MHC mediated antigen processing & presentation Innate Immune System Adaptive Immune System	Signaling by GPCR Signaling by FGFR in disease MEK activation FCERI mediated MAPK activation CREB phosphorylation through the activation of Ras Signaling by EGFRvIII in Cancer SHC1 events in ERBB2 signaling Signaling by SCF-KIT DAP12 signaling Rap1 signalling Gastrin-CREB signalling pathway via PKC and MAPK SOS-mediated signalling Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell SHC-mediated signalling Signaling by PDGF DAP12 interactions SHC-related events triggered by IGF1R GRB2 events in EGFR signaling Signaling by ERBB4 Signaling by ERBB2 Signaling by EGFR Signaling by Interleukins SHC1 events in ERBB4 signaling GP1b-IX-V activation signalling Signaling by VEGF Signalling to RAS Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Interleukin-2 signaling Platelet activation, signaling and aggregation Frs2-mediated activation Transmission across Chemical Synapses Adaptive Immune System Signaling by Leptin Signalling to ERKs Prolonged ERK activation events Axon guidance IRS-mediated signalling IGF1R signaling cascade VEGFA-VEGFR2 Pathway IRS-related events triggered by IGF1R Ion channel transport GRB2 events in ERBB2 signaling VEGFR2 mediated cell proliferation Activation of NMDA receptor upon glutamate binding and postsynaptic events RAF phosphorylates MEK Downstream signaling of activated FGFR Stimuli-sensing channels NCAM signaling for neurite out-growth RAF/MAP kinase cascade Signalling to p38 via RIT and RIN Post NMDA receptor activation events Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade SOS-mediated signalling SHC-mediated signalling Cytokine Signaling in Immune system IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane SHC-related events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR ARMS-mediated activation RAF activation SHC1 events in EGFR signaling IRS-mediated signalling FRS2-mediated cascade Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Drugs			Sorafenib Regorafenib Dabrafenib
Diseases
GWAS		Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)	Cardiac hypertrophy ( 21348951) Cholesterol, total ( 20686565)
Protein-Protein Interactions		167 interactors: AMFR ANAPC11 ARIH2 BARD1 BFAR BIRC2 BIRC3 BIRC7 BIRC8 BRCA1 BTRC CADPS2 CBL CBLC CCNB1 CDKN1B CHFR CNOT4 CUL3 DDX58 DTX1 DTX3 DTX3L DZIP3 EPS15 F12 FBXL3 FBXO2 FBXO4 FBXO7 FBXW2 FZR1 HERC4 HUWE1 ITCH KCMF1 LNX1 LRSAM1 LTN1 MAP3K1 MAPT MARCH3 MARCH5 MARCH6 MARCH7 MDM2 MDM4 MGRN1 MIB1 MID1 MKRN3 MUL1 MYLIP NEDD4 NEDD4L NFKBIA NHLRC1 NSMCE1 OTUB1 PARK2 PDZRN3 PELI1 PJA1 PJA2 POLL POLM QSOX1 RAF1 RAG1 RBX1 RCHY1 RELA RFFL RFWD2 RFWD3 RING1 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF125 RNF126 RNF13 RNF130 RNF135 RNF138 RNF14 RNF146 RNF150 RNF151 RNF165 RNF166 RNF167 RNF181 RNF185 RNF186 RNF2 RNF25 RNF26 RNF34 RNF38 RNF4 RNF43 RNF5 RNF7 RSPRY1 SIAH1 SIAH2 SOCS6 STAM2 STK11 STUB1 SYVN1 TOPORS TRAF6 TRAF7 TRAIP TRIM10 TRIM13 TRIM17 TRIM2 TRIM21 TRIM23 TRIM25 TRIM26 TRIM27 TRIM28 TRIM31 TRIM32 TRIM35 TRIM36 TRIM37 TRIM38 TRIM39 TRIM41 TRIM43 TRIM45 TRIM5 TRIM50 TRIM55 TRIM63 TRIM7 TRIM8 TTC3 UBA1 UBA6 UBASH3B UBC UBE3A UBE4A UBE4B UBOX5 UBR5 UFM1 UHRF2 VPRBP VPS18 WWP2 XIAP ZNRF1 ZNRF2 ZNRF4	123 interactors: ADCY6 AGTR1 AKT1 AR ARRB2 BAD BAG1 BCL2 BCL2L1 BCL6 BIRC2 BIRC3 BRAF CCT3 CDC25A CFLAR CNKSR1 COPS3 COPS7A CPS1 DCAF8 DMPK EFEMP1 ERBB2IP FYCO1 FYN GNB2 GNG4 GRB10 HRAS HSP90AA1 HSPA4 HSPA8 IL2RB INSR INTS10 JAK1 JAK2 KRAS KRT18 KRT8 KSR1 KSR2 LCK LRPAP1 MAP2K1 MAP2K2 MAP3K1 MAP3K5 MAPK1 MAPK3 MAPK7 MAPK8 MAPK8IP3 MRAS MYBPC1 MYC NEDD4 NPLOC4 NR3C1 NRAS NUDT14 OIP5 PACSIN3 PAK1 PAK2 PAK3 PBK PDGFRB PEBP1 PEBP4 PEX5L PHB PHKA2 PIN1 PKM PPP1CC PPP2CB PRKAA1 PRKACA PRKAR1A PRKCA PRKCD PRKCE PRKCZ PRKG1 PRPF6 PURA RANBP9 RAP1A RAP2A RASD2 RB1 RBBP8 RBL2 RFXANK RHEB RRAS RRAS2 RSU1 SHOC2 SPRY2 SPRY4 SRC STK26 STK3 STUB1 TBXA2R TIMM50 TMEM70 TSC22D3 UBC UBE2D2 VAV1 VDAC1 XIAP YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ YY1
Entrez ID		7322	5894
HPRD ID		04268	01265
Ensembl ID		ENSG00000131508	ENSG00000132155
Uniprot IDs		P62837	B4E0X2 L7RRS6 P04049
PDB IDs		1UR6 1W4U 2C4O 2CLW 2ESK 2ESO 2ESP 2ESQ 3A33 3JVZ 3JW0 3L1Y 3TGD 3ZNI 4A49 4A4B 4A4C 4AUQ 4DDG	1C1Y 1FAQ 1FAR 1GUA 1RFA 3CU8 3IQJ 3IQU 3IQV 3KUC 3KUD 3NKX 3O8I 3OMV 4FJ3 4G0N 4G3X 4IEA 4IHL
Enriched GO Terms of Interacting Partners?		Protein Ubiquitination Protein Modification By Small Protein Conjugation Cellular Protein Modification Process Cellular Protein Metabolic Process Protein Polyubiquitination Protein Metabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cellular Protein Catabolic Process Cellular Macromolecule Catabolic Process Protein Autoubiquitination Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Proteolysis Cellular Metabolic Process Catabolic Process Proteasomal Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Regulation Of Protein Ubiquitination Protein Monoubiquitination Metabolic Process Protein K63-linked Ubiquitination Regulation Of Protein Metabolic Process Negative Regulation Of Viral Release From Host Cell Regulation Of Viral Release From Host Cell Positive Regulation Of Protein Ubiquitination Regulation Of Cellular Protein Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Stress Positive Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stress Positive Regulation Of Protein Catabolic Process Regulation Of Signal Transduction Innate Immune Response Regulation Of Protein Catabolic Process Cellular Process Apoptotic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Programmed Cell Death Negative Regulation Of Protein Metabolic Process Negative Regulation Of Viral Process Cell Death Regulation Of Proteolysis Death Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Viral Entry Into Host Cell Regulation Of Signaling	Intracellular Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Phosphorylation Signal Transduction Regulation Of Phosphorus Metabolic Process Cell Communication Signaling Positive Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Growth Factor Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Protein Metabolic Process Regulation Of Intracellular Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Response To Growth Factor Response To Fibroblast Growth Factor Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Regulation Of MAPK Cascade Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Programmed Cell Death Neurotrophin Signaling Pathway Regulation Of Catalytic Activity Positive Regulation Of Protein Modification Process Apoptotic Process Positive Regulation Of Phosphorylation Cell Death Death Positive Regulation Of Cellular Metabolic Process Response To Stimulus Regulation Of Protein Phosphorylation Regulation Of Apoptotic Process Regulation Of Cell Death Positive Regulation Of Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Innate Immune Response Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Transferase Activity
Tagcloud ?		actb aging analysed comprehensive cows deltact differed dominant durations eif2b2 follicle follicles follicular fsh gapdh genorm geometric granulosa maternal normfinder preovulatory programs ranking reference reffinder rnf20 sf3a1 suitable threshold	cot densitometry erk2 hog immunoreactivities jnks kinases mapkapk2 mapks mek1 mekkl mkk3 mlk3 mos myocytes pak2 pakl phenomena probed proliferate proto rafb resist rsk1 rsk2 sekl tpl ventricle ventricles
Tagcloud (Difference) ?		actb aging analysed comprehensive cows deltact differed dominant durations eif2b2 follicle follicles follicular fsh gapdh genorm geometric granulosa maternal normfinder preovulatory programs ranking reference reffinder rnf20 sf3a1 suitable threshold	cot densitometry erk2 hog immunoreactivities jnks kinases mapkapk2 mapks mek1 mekkl mkk3 mlk3 mos myocytes pak2 pakl phenomena probed proliferate proto rafb resist rsk1 rsk2 sekl tpl ventricle ventricles
Tagcloud (Intersection) ?