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UBE2D2 and OTUB1
Number of citations of the paper that reports this interaction (PubMedID
33961781
)
97
Data Source:
BioGRID
(pull down, two hybrid, pull down, affinity chromatography technology)
UBE2D2
OTUB1
Description
ubiquitin conjugating enzyme E2 D2
OTU deubiquitinase, ubiquitin aldehyde binding 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Protein-containing Complex
Extracellular Exosome
Nucleoplasm
Cytoplasm
Cytosol
Extracellular Exosome
Molecular Function
Nucleotide Binding
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Transferase Activity
Ubiquitin Protein Ligase Activity
Ubiquitin Conjugating Enzyme Activity
Cysteine-type Deubiquitinase Activity
Protein Binding
Peptidase Activity
Cysteine-type Peptidase Activity
Hydrolase Activity
DeNEDDylase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin Binding
Ubiquitin-protein Transferase Inhibitor Activity
Biological Process
Protein Polyubiquitination
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Protein Modification Process
Protein Autoubiquitination
Protein K48-linked Ubiquitination
Adaptive Immune Response
Immune System Process
DNA Repair
Proteolysis
DNA Damage Response
Protein Deubiquitination
Cellular Response To Nutrient Levels
TORC1 Signaling
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K48-linked Deubiquitination
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Negative Regulation Of Double-strand Break Repair
Pathways
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
TICAM1, RIP1-mediated IKK complex recruitment
Downstream TCR signaling
FCERI mediated NF-kB activation
PINK1-PRKN Mediated Mitophagy
Regulation of TNFR1 signaling
CLEC7A (Dectin-1) signaling
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
Neddylation
Peroxisomal protein import
Negative regulators of DDX58/IFIH1 signaling
IKK complex recruitment mediated by RIP1
Inactivation of CSF3 (G-CSF) signaling
Antigen processing: Ubiquitination & Proteasome degradation
Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Ub-specific processing proteases
Ovarian tumor domain proteases
Drugs
(R,R)-2,3-Butanediol
Diseases
GWAS
Alzheimer's disease (late onset) (
30820047
)
Body mass index (
26426971
)
Immune reponse to smallpox (secreted IFN-alpha) (
22610502
)
Leukocyte telomere length (
32109421
)
Bipolar disorder (
31043756
)
Interacting Genes
244 interacting genes:
AMFR
ANAPC11
ANAPC2
AREL1
ARIH2
ARRDC3
BARD1
BFAR
BIRC2
BIRC3
BIRC7
BIRC8
BMI1
BRAP
BRCA1
BTRC
CADPS2
CBL
CBLB
CBLC
CCNB1
CDKN1B
CHFR
CNOT4
COP1
CUEDC1
CUL3
DCAF1
DTX1
DTX2
DTX3
DTX3L
DZIP3
EPS15
F12
FBXL3
FBXO2
FBXO4
FBXO7
FBXW2
HACE1
HECTD1
HECTD3
HECTD4
HECW1
HECW2
HERC1
HERC2
HERC4
HUWE1
ITCH
KAT2B
KCMF1
LNX1
LNX2
LRSAM1
LTN1
MAP3K1
MAPT
MARCHF3
MARCHF5
MARCHF6
MARCHF7
MDM2
MDM4
MEX3A
MEX3C
MGRN1
MIB1
MIB2
MID1
MID2
MKRN2
MKRN3
MUL1
MYCBP2
MYLIP
NAT10
NBR1
NEDD4
NEDD4L
NFKB1
NFKBIA
NPR1
NSMCE1
OBI1
OTUB1
PDZRN3
PELI1
PHF7
PHRF1
PJA1
PJA2
PMAIP1
POLL
POLM
PRKN
QSOX1
RAD18
RAF1
RAG1
RBCK1
RBX1
RC3H1
RC3H2
RCHY1
RELA
RFFL
RFWD3
RIGI
RING1
RLIM
RMND5B
RNF10
RNF103
RNF11
RNF111
RNF114
RNF115
RNF122
RNF123
RNF126
RNF13
RNF130
RNF135
RNF138
RNF14
RNF144A
RNF146
RNF149
RNF150
RNF151
RNF166
RNF167
RNF168
RNF170
RNF181
RNF185
RNF186
RNF19A
RNF19B
RNF2
RNF20
RNF213
RNF216
RNF220
RNF224
RNF25
RNF26
RNF31
RNF34
RNF38
RNF4
RNF40
RNF43
RNF5
RNF7
RNF8
RSPRY1
RTF2
SIAH1
SIAH2
SMURF1
SMURF2
SNCA
SOCS6
SPOP
STAM2
STK11
STUB1
SYVN1
TOPORS
TP53
TRAF2
TRAF6
TRAF7
TRAIP
TRIM10
TRIM11
TRIM13
TRIM17
TRIM2
TRIM21
TRIM23
TRIM25
TRIM26
TRIM27
TRIM28
TRIM3
TRIM31
TRIM32
TRIM33
TRIM34
TRIM35
TRIM36
TRIM37
TRIM38
TRIM39
TRIM41
TRIM43
TRIM45
TRIM46
TRIM47
TRIM5
TRIM50
TRIM54
TRIM55
TRIM62
TRIM63
TRIM65
TRIM7
TRIM8
TRIP12
TTC3
UBA1
UBA3
UBA5
UBA6
UBASH3B
UBD
UBE3A
UBE3C
UBE4A
UBE4B
UBOX5
UBR1
UBR2
UBR3
UBR4
UBR5
UFM1
UHRF1
UHRF2
UVSSA
VHL
VPS11
VPS18
WSB1
WWP1
WWP2
XIAP
ZNRF1
ZNRF2
ZNRF4
59 interacting genes:
ACVR1
ACVR1B
ANXA1
ANXA7
AURKA
BIRC2
BMPR1A
BMPR1B
CCN6
CD274
CDKN1A
CEBPA
CPEB2
CSNK2A1
ECT2
ESR1
H2AX
HSF1
IL1RL2
KDM1A
LINC00857
MAPT
MSH2
MYC
NEDD8
OTUD6B
PJA1
RFFL
RHOA
RNF126
RNF128
SETD7
SMAD2
SMAD3
SMAD4
SMAD9
SNAI1
TGFBR1
TP53
TRAF6
TRIM54
TRIM55
TRIM63
TSC22D1
TTR
UBA6
UBC
UBD
UBE2D2
UBE2D3
UBE2D4
UBE2E2
UBE2S
UBE2Z
UBE4B
USP15
USP21
USP28
YAP1
Entrez ID
7322
55611
HPRD ID
04268
08493
Ensembl ID
ENSG00000131508
ENSG00000167770
Uniprot IDs
P62837
B3KUV5
Q96FW1
PDB IDs
1UR6
1W4U
2CLW
2ESK
2ESO
2ESP
2ESQ
3A33
3JVZ
3JW0
3L1Y
3TGD
3ZNI
4A49
4A4B
4A4C
4AUQ
4DDG
4DDI
4LDT
4V3K
4V3L
4WZ3
5D0K
5D0M
5D1K
5D1L
5D1M
5EDV
5MNJ
5ULF
5ULH
5ULK
5VZW
5ZBU
6HPR
6M2C
6SQO
6SQR
6SQS
6TTU
6W7Z
6W9D
7AI0
7AI1
7BOL
7R71
8B3I
8GBQ
8GCB
8GRM
8JWJ
8JWU
8V0D
8VK8
8VK9
2ZFY
3VON
4DDG
4DDI
4DHZ
4I6L
4LDT
Enriched GO Terms of Interacting Partners
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Ubiquitin Protein Ligase Activity
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Post-translational Protein Modification
Ubiquitin-protein Transferase Activity
Protein Modification Process
Transferase Activity
Protein Metabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Protein Polyubiquitination
Proteolysis Involved In Protein Catabolic Process
Zinc Ion Binding
Macromolecule Catabolic Process
Proteolysis
Macromolecule Metabolic Process
Metal Ion Binding
Catabolic Process
Protein Autoubiquitination
Proteasomal Protein Catabolic Process
Protein Catabolic Process
Protein K48-linked Ubiquitination
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein K63-linked Ubiquitination
Ubiquitin Ligase Complex
Cytoplasm
Protein Monoubiquitination
Response To Stress
Regulation Of Signal Transduction
Immune System Process
Cellular Response To Stress
Regulation Of Signaling
Regulation Of Cell Communication
Negative Regulation Of Signal Transduction
Regulation Of Intracellular Signal Transduction
Ubiquitin-ubiquitin Ligase Activity
Positive Regulation Of Protein Ubiquitination
Suppression Of Viral Release By Host
Innate Immune Response
Positive Regulation Of Catabolic Process
Ubiquitin Protein Ligase Binding
Positive Regulation Of Post-translational Protein Modification
Regulation Of Post-translational Protein Modification
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Ubiquitin Binding
Positive Regulation Of Protein Metabolic Process
Regulation Of Protein Ubiquitination
Canonical NF-kappaB Signal Transduction
Defense Response To Symbiont
Post-translational Protein Modification
Protein Modification Process
Regulation Of Programmed Cell Death
Protein Ubiquitination
Regulation Of Apoptotic Process
Protein Metabolic Process
Protein Modification By Small Protein Conjugation
Macromolecule Metabolic Process
Positive Regulation Of Cell Differentiation
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Metabolic Process
SMAD Binding
Modification-dependent Protein Catabolic Process
I-SMAD Binding
Regulation Of Cell Differentiation
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Positive Regulation Of Developmental Process
In Utero Embryonic Development
Negative Regulation Of Apoptotic Process
Ubiquitin-dependent Protein Catabolic Process
Chordate Embryonic Development
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Gene Expression
Negative Regulation Of Programmed Cell Death
Proteolysis Involved In Protein Catabolic Process
Embryo Development Ending In Birth Or Egg Hatching
Multicellular Organism Development
Response To Stress
Protein Polyubiquitination
Proteolysis
Regulation Of Metabolic Process
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Biosynthetic Process
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Nucleus
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Transforming Growth Factor Beta Receptor Activity, Type I
Activin Receptor Signaling Pathway
Response To Growth Factor
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Primary Metabolic Process
Negative Regulation Of Metabolic Process
Macromolecule Catabolic Process
Regulation Of Gene Expression
Regulation Of Developmental Process
Ubiquitin Conjugating Enzyme Activity
Response To Ionizing Radiation
Positive Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Macromolecule Biosynthetic Process
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Tagcloud (Intersection)
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