UBE2D2 and NFKB1

Number of citations of the paper that reports this interaction (PubMedID 9535861)
0

Data Source:
BioGRID (enzymatic study)

		UBE2D2	NFKB1
Description		ubiquitin conjugating enzyme E2 D2	nuclear factor kappa B subunit 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Protein-containing Complex Extracellular Exosome	Chromatin Extracellular Region Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Cytosol I-kappaB/NF-kappaB Complex Secretory Granule Lumen NF-kappaB P50/p65 Complex Specific Granule Lumen
	Molecular Function	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Transcription Coregulator Activity Protein Binding Identical Protein Binding Actinin Binding Sequence-specific DNA Binding Protein Sequestering Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification Process Protein Autoubiquitination Protein K48-linked Ubiquitination	Negative Regulation Of Transcription By RNA Polymerase II MAPK Cascade Negative Regulation Of Cytokine Production Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Inflammatory Response Signal Transduction Canonical NF-kappaB Signal Transduction JNK Cascade Gene Expression Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Efflux Positive Regulation Of Lipid Storage Negative Regulation Of Vitamin D Biosynthetic Process Signal Transduction Involved In Regulation Of Gene Expression Negative Regulation Of Interleukin-12 Production Tumor Necrosis Factor-mediated Signaling Pathway Response To Muscle Stretch Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response B Cell Receptor Signaling Pathway Mammary Gland Involution Positive Regulation Of Transcription Initiation By RNA Polymerase II Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Nicotine Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To DsRNA Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Interleukin-17 Cellular Response To Virus Antibacterial Innate Immune Response Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Hyaluronan Biosynthetic Process Cellular Response To Angiotensin Positive Regulation Of MiRNA Metabolic Process
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation PINK1-PRKN Mediated Mitophagy Regulation of TNFR1 signaling CLEC7A (Dectin-1) signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Regulated proteolysis of p75NTR Downstream TCR signaling NF-kB is activated and signals survival Senescence-Associated Secretory Phenotype (SASP) FCERI mediated NF-kB activation DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines Transcriptional regulation of white adipocyte differentiation TAK1-dependent IKK and NF-kappa-B activation Interleukin-1 processing IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling CD209 (DC-SIGN) signaling CLEC7A/inflammasome pathway MAP3K8 (TPL2)-dependent MAPK1/3 activation Neutrophil degranulation The NLRP3 inflammasome Transcriptional Regulation by VENTX Interleukin-1 signaling TRAF6 mediated NF-kB activation HCMV Early Events Purinergic signaling in leishmaniasis infection SARS-CoV-1 activates/modulates innate immune responses Regulation of NFE2L2 gene expression Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells Regulation of PD-L1(CD274) transcription
Drugs		(R,R)-2,3-Butanediol	Sulfasalazine Donepezil Pseudoephedrine Pranlukast Pranlukast HE3286 P54 NOX-700 SGN-30 Custirsen NF-kappaB Decoy Andrographolide Triflusal Terpinen-4-ol Glycyrrhizic acid Fish oil SC-236
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Body mass index ( 26426971) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Leukocyte telomere length ( 32109421)	Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic rhinitis ( 30013184) Allergic sensitization ( 30013184) Basophil percentage of white cells ( 32888494) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Copper levels ( 26025379) Creatinine levels ( 29124443) Crohn's disease ( 28067908) Eosinophil count ( 27863252 32888494) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Estimated glomerular filtration rate ( 29124443 30604766) Glomerular filtration rate (creatinine) ( 26831199) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Immature fraction of reticulocytes ( 32888494) Inflammatory bowel disease ( 28067908) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Membranous nephropathy ( 32231244) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 21833088) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Non-albumin protein levels ( 29403010) Primary biliary cholangitis ( 28425483 23000144 26394269 28062665 21399635 30643196) Primary biliary cirrhosis ( 22961000) Primary sclerosing cholangitis ( 27992413) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia (treatment resistant) ( 22479419) Serum total protein levels ( 29403010) Serum uric acid levels ( 29124443) Sum eosinophil basophil counts ( 27863252) Systemic sclerosis ( 31672989 30247649) Tonsillectomy ( 27182965 28928442) Ulcerative colitis ( 23128233) White blood cell count ( 32888494)
Interacting Genes		244 interacting genes: AMFR ANAPC11 ANAPC2 AREL1 ARIH2 ARRDC3 BARD1 BFAR BIRC2 BIRC3 BIRC7 BIRC8 BMI1 BRAP BRCA1 BTRC CADPS2 CBL CBLB CBLC CCNB1 CDKN1B CHFR CNOT4 COP1 CUEDC1 CUL3 DCAF1 DTX1 DTX2 DTX3 DTX3L DZIP3 EPS15 F12 FBXL3 FBXO2 FBXO4 FBXO7 FBXW2 HACE1 HECTD1 HECTD3 HECTD4 HECW1 HECW2 HERC1 HERC2 HERC4 HUWE1 ITCH KAT2B KCMF1 LNX1 LNX2 LRSAM1 LTN1 MAP3K1 MAPT MARCHF3 MARCHF5 MARCHF6 MARCHF7 MDM2 MDM4 MEX3A MEX3C MGRN1 MIB1 MIB2 MID1 MID2 MKRN2 MKRN3 MUL1 MYCBP2 MYLIP NAT10 NBR1 NEDD4 NEDD4L NFKB1 NFKBIA NPR1 NSMCE1 OBI1 OTUB1 PDZRN3 PELI1 PHF7 PHRF1 PJA1 PJA2 PMAIP1 POLL POLM PRKN QSOX1 RAD18 RAF1 RAG1 RBCK1 RBX1 RC3H1 RC3H2 RCHY1 RELA RFFL RFWD3 RIGI RING1 RLIM RMND5B RNF10 RNF103 RNF11 RNF111 RNF114 RNF115 RNF122 RNF123 RNF126 RNF13 RNF130 RNF135 RNF138 RNF14 RNF144A RNF146 RNF149 RNF150 RNF151 RNF166 RNF167 RNF168 RNF170 RNF181 RNF185 RNF186 RNF19A RNF19B RNF2 RNF20 RNF213 RNF216 RNF220 RNF224 RNF25 RNF26 RNF31 RNF34 RNF38 RNF4 RNF40 RNF43 RNF5 RNF7 RNF8 RSPRY1 RTF2 SIAH1 SIAH2 SMURF1 SMURF2 SNCA SOCS6 SPOP STAM2 STK11 STUB1 SYVN1 TOPORS TP53 TRAF2 TRAF6 TRAF7 TRAIP TRIM10 TRIM11 TRIM13 TRIM17 TRIM2 TRIM21 TRIM23 TRIM25 TRIM26 TRIM27 TRIM28 TRIM3 TRIM31 TRIM32 TRIM33 TRIM34 TRIM35 TRIM36 TRIM37 TRIM38 TRIM39 TRIM41 TRIM43 TRIM45 TRIM46 TRIM47 TRIM5 TRIM50 TRIM54 TRIM55 TRIM62 TRIM63 TRIM65 TRIM7 TRIM8 TRIP12 TTC3 UBA1 UBA3 UBA5 UBA6 UBASH3B UBD UBE3A UBE3C UBE4A UBE4B UBOX5 UBR1 UBR2 UBR3 UBR4 UBR5 UFM1 UHRF1 UHRF2 UVSSA VHL VPS11 VPS18 WSB1 WWP1 WWP2 XIAP ZNRF1 ZNRF2 ZNRF4	106 interacting genes: ABCC2 APBB2 AR ATF3 BARD1 BCL3 BRCA1 BTRC CDK9 CEBPB CFLAR CHUK COPB2 COPS5 CTNNB1 DNMT3L E2F1 ECSIT ELF1 ELF3 ESR1 ETS1 FBXO7 FBXW11 FOS G3BP2 GLUL GSK3B HDAC1 HMGA1 HMGA2 HMGB1 HSPA4 IKBKB IKBKG IL2RA IRF1 IRF2 IRF8 IRF9 ITGB3BP KAT5 KLF5 KPNA3 LYL1 MAP3K8 MEN1 MTPN NCOA1 NCOA6 NCOR2 NFKB2 NFKBIA NFKBIB NFKBIE NFKBIZ NFRKB NKRF NOTCH1 NR3C1 NR4A1 PALS2 PARP1 PCBD1 PDCD11 PELP1 PLD3 PML PPARG PPP4C PRKACA PSMD10 REL RELA RELB RGS14 RIPK1 RPS3 RSF1 RXRA SERPINA3 SF1 SIN3A SP1 SPAG9 SPI1 SPPL2A SRF STAT3 STAT6 TAB2 TFAP2A TNFSF11 TNIP2 TP53BP1 TP53BP2 TRIP4 TSC22D3 TXN UBE2D2 UBE2D3 UBE2K UNC5CL YWHAQ YY1 ZBTB9
Entrez ID		7322	4790
HPRD ID		04268	01238
Ensembl ID		ENSG00000131508	ENSG00000109320
Uniprot IDs		P62837	P19838
PDB IDs		1UR6 1W4U 2CLW 2ESK 2ESO 2ESP 2ESQ 3A33 3JVZ 3JW0 3L1Y 3TGD 3ZNI 4A49 4A4B 4A4C 4AUQ 4DDG 4DDI 4LDT 4V3K 4V3L 4WZ3 5D0K 5D0M 5D1K 5D1L 5D1M 5EDV 5MNJ 5ULF 5ULH 5ULK 5VZW 5ZBU 6HPR 6M2C 6SQO 6SQR 6SQS 6TTU 6W7Z 6W9D 7AI0 7AI1 7BOL 7R71 8B3I 8GBQ 8GCB 8GRM 8JWJ 8JWU 8V0D 8VK8 8VK9	1MDI 1MDJ 1MDK 1NFI 1SVC 2DBF 2O61 3GUT 7LEQ 7LET 7LF4 7LFC 7RG4 7RG5 8TQD
Enriched GO Terms of Interacting Partners?		Ubiquitin Protein Ligase Activity Protein Ubiquitination Protein Modification By Small Protein Conjugation Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Modification Process Transferase Activity Protein Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Zinc Ion Binding Macromolecule Catabolic Process Proteolysis Macromolecule Metabolic Process Metal Ion Binding Catabolic Process Protein Autoubiquitination Proteasomal Protein Catabolic Process Protein Catabolic Process Protein K48-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K63-linked Ubiquitination Ubiquitin Ligase Complex Cytoplasm Protein Monoubiquitination Response To Stress Regulation Of Signal Transduction Immune System Process Cellular Response To Stress Regulation Of Signaling Regulation Of Cell Communication Negative Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Ubiquitin-ubiquitin Ligase Activity Positive Regulation Of Protein Ubiquitination Suppression Of Viral Release By Host Innate Immune Response Positive Regulation Of Catabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Post-translational Protein Modification Regulation Of Post-translational Protein Modification Negative Regulation Of Signaling Negative Regulation Of Cell Communication Ubiquitin Binding Positive Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Canonical NF-kappaB Signal Transduction Defense Response To Symbiont	Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Gene Expression Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleus Chromatin Transcription Cis-regulatory Region Binding Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Response To Stress RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Regulation Of Apoptotic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Programmed Cell Death Negative Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Factor Activity Intracellular Signal Transduction Response To Cytokine Response To Peptide Sequence-specific DNA Binding Regulation Of Intracellular Signal Transduction Canonical NF-kappaB Signal Transduction RNA Polymerase II-specific DNA-binding Transcription Factor Binding Non-canonical NF-kappaB Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Developmental Process Transcription Regulator Complex
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