ELP1 and ELP2

Number of citations of the paper that reports this interaction (PubMedID 36617428)
102

Data Source:
BioGRID (affinity chromatography technology, biochemical, pull down, cross-linking study)

		ELP1	ELP2
Description		elongator acetyltransferase complex subunit 1	elongator acetyltransferase complex subunit 2
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Elongator Holoenzyme Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Transcription Elongation Factor Complex Elongator Holoenzyme Complex
	Molecular Function	TRNA Binding Protein Binding	RNA Polymerase II Complex Binding Protein Kinase Binding
	Biological Process	TRNA Wobble Uridine Modification TRNA Wobble Base 5-methoxycarbonylmethyl-2-thiouridinylation Regulation Of Translation TRNA Processing	TRNA Wobble Uridine Modification Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Regulation Of Translation TRNA Processing Regulation Of Receptor Signaling Pathway Via JAK-STAT
Pathways		HATs acetylate histones	HATs acetylate histones
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)	Serum metabolite levels ( 33031748)
Interacting Genes		27 interacting genes: BAG6 BARD1 CCT5 CDKN2B CHUK CSTF2 ELP2 ELP3 ELP6 HTT IKBKB IRF4 MAN2A2 MAP3K14 MAP3K7 MAPK8 MRPL42 NDUFB9 NFKBIA NIPSNAP3A PBX2 PLP2 SDHAF2 SNAPIN TAC3 TTR TXNDC9	8 interacting genes: CTDP1 ELP1 ELP6 JAK1 JAK2 STAT1 STAT3 STAT5B
Entrez ID		8518	55250
HPRD ID		04763	15443
Ensembl ID		ENSG00000070061	ENSG00000134759
Uniprot IDs		A0A6Q8PGW3 A0A6Q8PHA0 B3KNB2 B4E3I9 F5H2T0 O95163 Q8N516	Q6IA86
PDB IDs		5CQR 8PTX 8PTY 8PTZ 8PU0	8PTX 8PTY 8PTZ 8PU0
Enriched GO Terms of Interacting Partners?		Non-canonical NF-kappaB Signal Transduction Elongator Holoenzyme Complex TRNA Wobble Uridine Modification Immune Response-regulating Signaling Pathway Canonical NF-kappaB Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway IkappaB Kinase Activity Fc-epsilon Receptor Signaling Pathway Stress-activated MAPK Cascade Innate Immune Response-activating Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Interleukin-1-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Activation Of Innate Immune Response Immune Response-activating Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Signal Transduction Involved In Regulation Of Gene Expression Response To Tumor Necrosis Factor Immune Response-activating Cell Surface Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Activation Of Immune Response Cell Surface Toll-like Receptor Signaling Pathway IkappaB Kinase Complex Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Innate Immune Response Regulation Of Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Tumor Necrosis Factor-mediated Signaling Pathway CD40 Receptor Complex Transferrin Receptor Binding TRIF-dependent Toll-like Receptor Signaling Pathway Cytosol Scaffold Protein Binding MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MAP Kinase Activity Regulation Of Cytokine Production Involved In Inflammatory Response TRNA Modification Protein Serine/threonine Kinase Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Immune Response Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway	Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Growth Hormone Receptor Signaling Pathway Interleukin-9-mediated Signaling Pathway CCR5 Chemokine Receptor Binding Type II Interferon-mediated Signaling Pathway Interleukin-6-mediated Signaling Pathway Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Skeletal Muscle Cell Proliferation Regulation Of Erythrocyte Differentiation Response To Cytokine Response To Peptide Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Interleukin-23-mediated Signaling Pathway Elongator Holoenzyme Complex Interferon-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway RNA Metabolic Process Erythropoietin-mediated Signaling Pathway Growth Hormone Receptor Binding Interleukin-10-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Cellular Response To Hormone Stimulus Interleukin-2-mediated Signaling Pathway Regulation Of Defense Response Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Myeloid Cell Differentiation T-helper 17 Cell Lineage Commitment Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Regulation Of Skeletal Muscle Satellite Cell Proliferation Regulation Of Natural Killer Cell Proliferation Nuclear Glucocorticoid Receptor Binding Regulation Of Skeletal Muscle Cell Proliferation TRNA Wobble Uridine Modification Cellular Response To Cytokine Stimulus RNA Polymerase II Transcription Regulator Complex T-helper Cell Lineage Commitment Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Homotypic Cell-cell Adhesion Photoreceptor Cell Differentiation Regulation Of Macromolecule Biosynthetic Process CD4-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Primary Metabolic Process Alpha-beta T Cell Lineage Commitment Positive Regulation Of Cytokine Production
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