IKBKAP and TAC3

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		IKBKAP	TAC3
Gene Name		inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	tachykinin 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleolus Cytoplasm Transcription Elongation Factor Complex Elongator Holoenzyme Complex	Extracellular Region Extracellular Space Extracellular Vesicular Exosome
	Molecular Function	RNA Polymerase II Core Binding Signal Transducer Activity Protein Binding Phosphorylase Kinase Regulator Activity	Receptor Binding Protein Binding
	Biological Process	Chromatin Organization Regulation Of Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Protein Complex Assembly Protein Phosphorylation Immune Response Signal Transduction Positive Regulation Of Cell Migration Regulation Of Protein Kinase Activity	Tachykinin Receptor Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Tachykinin receptors bind tachykinins Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: BAG6 BARD1 CCT5 CDKN2B CHUK CSTF2 ELP2 ELP3 HTT IKBKB IRF4 MAN2A2 MAP3K14 MAP3K7 MAPK8 MRPL42 NDUFB9 NFKBIA NIPSNAP3A PBX2 PLP2 SDHAF2 SNAPIN TAC3 TTR TXNDC9	10 interactors: CCDC90B FEZ1 GPRASP1 IKBKAP PTN TACR1 TACR2 TACR3 UBC UBR1
Entrez ID		8518	6866
HPRD ID		04763	08877
Ensembl ID		ENSG00000070061	ENSG00000166863
Uniprot IDs		O95163 Q8N516	Q9UHF0
PDB IDs			1P9F
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Toll-like Receptor 4 Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Response To External Stimulus Positive Regulation Of Innate Immune Response Fc-epsilon Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Innate Immune Response T Cell Receptor Signaling Pathway Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Fc Receptor Signaling Pathway Internal Protein Amino Acid Acetylation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Acetylation Antigen Receptor-mediated Signaling Pathway Histone H3 Acetylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Apoptotic Process Positive Regulation Of Cytokine Production Negative Regulation Of Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Peptidyl-amino Acid Modification Regulation Of Signal Transduction Negative Regulation Of Cell Death Intracellular Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Response To Other Organism Positive Regulation Of Type I Interferon Production	Tachykinin Receptor Signaling Pathway Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Smooth Muscle Contraction Regulation Of Smooth Muscle Contraction Operant Conditioning Neuropeptide Signaling Pathway Positive Regulation Of Vascular Permeability Learning Regulation Of Muscle Contraction Regulation Of Vascular Permeability Positive Regulation Of Blood Pressure Response To Morphine Learning Or Memory Response To Electrical Stimulus Excretion Cognition Blood Circulation Smooth Muscle Contraction Cellular Response To Stimulus Positive Regulation Of Acetylcholine Secretion, Neurotransmission Response To Abiotic Stimulus Single-organism Behavior Response To Ammonium Ion Negative Regulation Of Signaling Cellular Response To Leucine G-protein Coupled Receptor Catabolic Process Positive Regulation Of Synaptic Transmission Response To Estradiol Intestine Smooth Muscle Contraction Negative Regulation Of Luteinizing Hormone Secretion Angiotensin-mediated Drinking Behavior Smooth Muscle Contraction Involved In Micturition Synaptic Transmission Behavior Response To Organic Substance Response To Stimulus Response To Alkaloid Regulation Of Acetylcholine Secretion, Neurotransmission Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Saliva Secretion Regulation Of Blood Pressure Regulation Of Cellular Process Prolactin Secretion Negative Regulation Of Gonadotropin Secretion Regulation Of Synaptic Transmission, Cholinergic Response To Leucine Regulation Of Saliva Secretion Micturition Response To Ozone Endosomal Transport
Tagcloud ?		advance autonomously autosomal awaited believed compensate deficiencies devastating dysautonomia faithfully fd hallmark ikap implicating myelin myelination neurodevelopmental oli oligodendrocyte postmortem proof reason recapitulate recessive scarcity severely skipping splice underscoring	bioinformatics cichlids dispersed fsh fxglm gonadotropin holds isoleucine lh luc neurokinin nh2 nkb nkbs nkf piscine pituitary possess possessing reproduction sre tac3r tac3ra tac3rb tachikinin tilapia tinkb tinkf valine
Tagcloud (Difference) ?		advance autonomously autosomal awaited believed compensate deficiencies devastating dysautonomia faithfully fd hallmark ikap implicating myelin myelination neurodevelopmental oli oligodendrocyte postmortem proof reason recapitulate recessive scarcity severely skipping splice underscoring	bioinformatics cichlids dispersed fsh fxglm gonadotropin holds isoleucine lh luc neurokinin nh2 nkb nkbs nkf piscine pituitary possess possessing reproduction sre tac3r tac3ra tac3rb tachikinin tilapia tinkb tinkf valine
Tagcloud (Intersection) ?