IKBKAP and IRF4

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (affinity chromatography technology, pull down)

		IKBKAP	IRF4
Gene Name		inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein	interferon regulatory factor 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleolus Cytoplasm Transcription Elongation Factor Complex Elongator Holoenzyme Complex	Nuclear Nucleosome Nucleus Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	RNA Polymerase II Core Binding Signal Transducer Activity Protein Binding Phosphorylase Kinase Regulator Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein-lysine N-methyltransferase Activity Sequence-specific DNA Binding
	Biological Process	Chromatin Organization Regulation Of Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Protein Complex Assembly Protein Phosphorylation Immune Response Signal Transduction Positive Regulation Of Cell Migration Regulation Of Protein Kinase Activity	Transcription, DNA-templated Peptidyl-lysine Methylation Cytokine-mediated Signaling Pathway Negative Regulation Of Toll-like Receptor Signaling Pathway T Cell Activation Defense Response To Protozoan Myeloid Dendritic Cell Differentiation Positive Regulation Of DNA Binding Histone H3 Acetylation Histone H4 Acetylation Positive Regulation Of Interleukin-10 Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Interleukin-13 Biosynthetic Process Positive Regulation Of Interleukin-4 Biosynthetic Process Regulation Of T-helper Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway T-helper 17 Cell Lineage Commitment
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Interferon alpha/beta signaling
Drugs
Diseases
GWAS			Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Celiac disease ( 20190752) Chronic lymphocytic leukemia ( 18758461) Eye color ( 20585627) Freckles ( 17952075) Freckling ( 20585627) Hair color ( 23548203 20585627) Hematology traits ( 23303382) Non-melanoma skin cancer ( 23548203) Progressive supranuclear palsy ( 21685912) Sunburns ( 23548203) Tanning ( 23548203)
Protein-Protein Interactions		26 interactors: BAG6 BARD1 CCT5 CDKN2B CHUK CSTF2 ELP2 ELP3 HTT IKBKB IRF4 MAN2A2 MAP3K14 MAP3K7 MAPK8 MRPL42 NDUFB9 NFKBIA NIPSNAP3A PBX2 PLP2 SDHAF2 SNAPIN TAC3 TTR TXNDC9	19 interactors: BATF BCL6 ETV7 FKBP4 HOXB13 HOXC11 IKBKAP IRAK1 MYD88 NFATC2 PRDM1 PROX1 SPI1 SPIB STAT6 TLK2 TOP1 TRAF2 YTHDC2
Entrez ID		8518	3662
HPRD ID		04763	03543
Ensembl ID		ENSG00000070061	ENSG00000137265
Uniprot IDs		O95163 Q8N516	Q15306
PDB IDs			2DLL
Enriched GO Terms of Interacting Partners?		Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Toll-like Receptor 4 Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Response To External Stimulus Positive Regulation Of Innate Immune Response Fc-epsilon Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Innate Immune Response T Cell Receptor Signaling Pathway Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Fc Receptor Signaling Pathway Internal Protein Amino Acid Acetylation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Acetylation Antigen Receptor-mediated Signaling Pathway Histone H3 Acetylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Apoptotic Process Positive Regulation Of Cytokine Production Negative Regulation Of Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Peptidyl-amino Acid Modification Regulation Of Signal Transduction Negative Regulation Of Cell Death Intracellular Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Response To Other Organism Positive Regulation Of Type I Interferon Production	Regulation Of Gene Expression Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated Regulation Of RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process RNA Metabolic Process Positive Regulation Of Cell Activation Regulation Of Nitrogen Compound Metabolic Process Cellular Metabolic Process Gene Expression Positive Regulation Of B Cell Activation Cellular Macromolecule Biosynthetic Process Regulation Of Metabolic Process Macromolecule Biosynthetic Process Regulation Of Lymphocyte Activation Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Response To Stress Regulation Of Cell Activation Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation Cellular Nitrogen Compound Metabolic Process Cell Fate Commitment Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Developmental Process Nitrogen Compound Metabolic Process Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Regulation Of B Cell Proliferation Negative Regulation Of Nucleic Acid-templated Transcription T-helper Cell Lineage Commitment Negative Regulation Of RNA Biosynthetic Process Immune System Process Type 2 Immune Response Epithelial Cell Development CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Type 2 Immune Response Organ Development Lymphocyte Differentiation Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Metabolic Process Toll-like Receptor 4 Signaling Pathway Regulation Of Immune Response
Tagcloud ?		advance autonomously autosomal awaited believed compensate deficiencies devastating dysautonomia faithfully fd hallmark ikap implicating myelin myelination neurodevelopmental oli oligodendrocyte postmortem proof reason recapitulate recessive scarcity severely skipping splice underscoring	ablation abolish adhesions attenuate chip cistrome compromise decidual decidualization decidualized deep focal forkhead foxo1 hesc igfbp1 integrating intervals o1a occupancy ontology overlap pka pr prl seq shared transcriptome wnt4
Tagcloud (Difference) ?		advance autonomously autosomal awaited believed compensate deficiencies devastating dysautonomia faithfully fd hallmark ikap implicating myelin myelination neurodevelopmental oli oligodendrocyte postmortem proof reason recapitulate recessive scarcity severely skipping splice underscoring	ablation abolish adhesions attenuate chip cistrome compromise decidual decidualization decidualized deep focal forkhead foxo1 hesc igfbp1 integrating intervals o1a occupancy ontology overlap pka pr prl seq shared transcriptome wnt4
Tagcloud (Intersection) ?