ELP1 and IRF4

Number of citations of the paper that reports this interaction (PubMedID 21903422)
55

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ELP1	IRF4
Description		elongator acetyltransferase complex subunit 1	interferon regulatory factor 4
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Elongator Holoenzyme Complex	Chromatin Nucleosome Nucleus Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	TRNA Binding Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	TRNA Wobble Uridine Modification TRNA Wobble Base 5-methoxycarbonylmethyl-2-thiouridinylation Regulation Of Translation TRNA Processing	Immune System Process Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production Negative Regulation Of Toll-like Receptor Signaling Pathway T Cell Activation Defense Response To Protozoan Myeloid Dendritic Cell Differentiation Regulation Of T-helper Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Multicellular Organismal Process T-helper 17 Cell Lineage Commitment Positive Regulation Of Cold-induced Thermogenesis
Pathways		HATs acetylate histones	Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Interferon alpha/beta signaling Nuclear events stimulated by ALK signaling in cancer Regulation of MITF-M-dependent genes involved in pigmentation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)	Age at first sexual intercourse ( 34211149) Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081) Alopecia areata ( 25608926) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune thyroid disease ( 32581359) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Basal cell carcinoma ( 31174203 27539887) Black vs. blond hair color ( 18483556) Black vs. red hair color ( 18483556) Blond vs non-blond hair color ( 26184321) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Brown vs. non-brown hair color ( 26184321) Celiac disease ( 22057235 20190752) Chronic lymphocytic leukemia ( 28165464 26956414 23770605 24292274 18758461) Crohn's disease ( 26192919) Cutaneous squamous cell carcinoma ( 27424798 32041948) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Epstein-Barr virus EA-D antibody levels ( 33204752) Eye color ( 20585627 30664655) Eye color (brightness) ( 30664655) Eye color traits ( 30166351) Facial pigmentation ( 25705849) Feeling nervous ( 29500382) Freckles ( 17952075) Freckling ( 20585627) Hair color ( 30664655 20585627 29662168 23548203 26926045) Hair greying ( 26926045) Hair morphology traits ( 30166351) Hematology traits ( 23303382) IgA nephropathy ( 32912934) Inflammatory bowel disease ( 26192919) Keratinocyte cancer (MTAG) ( 31174203) Light vs. dark hair color ( 26184321) Limited cutaneous systemic scleroderma ( 29293537) Low tan response ( 29739929) Lung adenocarcinoma ( 28604730) Lung cancer in ever smokers ( 28604730) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 32888494) Male-pattern baldness ( 27182965 29146897 28196072) Medication use (thyroid preparations) ( 31015401) Melanoma ( 28212542) Membranous nephropathy ( 32231244) Monobrow ( 27182965) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Nevus count ( 30429480) Non-melanoma skin cancer ( 29739929 23548203) Progressive supranuclear palsy ( 21685912) Psoriasis ( 25903422 23143594 25574825) Rheumatoid arthritis ( 30423114 24390342) Rosacea symptom severity ( 29771307) Skin aging (microtopography measurement) ( 28502801) Skin colour saturation ( 25963972) Skin pigmentation ( 30664655) Skin pigmentation traits ( 30166351) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Squamous cell carcinoma ( 26829030 31174203) Sunburns ( 23548203) Systemic lupus erythematosus ( 33536424) Tanning ( 23548203) Type 1 diabetes ( 34012112 34127860) Vitiligo ( 27723757) White blood cell count ( 32888494) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		27 interacting genes: BAG6 BARD1 CCT5 CDKN2B CHUK CSTF2 ELP2 ELP3 ELP6 HTT IKBKB IRF4 MAN2A2 MAP3K14 MAP3K7 MAPK8 MRPL42 NDUFB9 NFKBIA NIPSNAP3A PBX2 PLP2 SDHAF2 SNAPIN TAC3 TTR TXNDC9	22 interacting genes: BATF BCL6 ELP1 ETV7 FKBP4 GIPC2 HOXB13 HOXC11 IRAK1 MYD88 NFATC2 PRDM1 PROX1 SPI1 SPIB STAT6 TLK2 TOP1 TRAF2 TSEN54 USP4 YTHDC2
Entrez ID		8518	3662
HPRD ID		04763	03543
Ensembl ID		ENSG00000070061	ENSG00000137265
Uniprot IDs		A0A6Q8PGW3 A0A6Q8PHA0 B3KNB2 B4E3I9 F5H2T0 O95163 Q8N516	Q15306
PDB IDs		5CQR 8PTX 8PTY 8PTZ 8PU0	2DLL 6TD4 7JM4 7O56 7OGS 7OOT 7RH2
Enriched GO Terms of Interacting Partners?		Non-canonical NF-kappaB Signal Transduction Elongator Holoenzyme Complex TRNA Wobble Uridine Modification Immune Response-regulating Signaling Pathway Canonical NF-kappaB Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway IkappaB Kinase Activity Fc-epsilon Receptor Signaling Pathway Stress-activated MAPK Cascade Innate Immune Response-activating Signaling Pathway Stress-activated Protein Kinase Signaling Cascade Interleukin-1-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Activation Of Innate Immune Response Immune Response-activating Signaling Pathway Cytoplasmic Pattern Recognition Receptor Signaling Pathway Signal Transduction Involved In Regulation Of Gene Expression Response To Tumor Necrosis Factor Immune Response-activating Cell Surface Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Activation Of Immune Response Cell Surface Toll-like Receptor Signaling Pathway IkappaB Kinase Complex Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Innate Immune Response Regulation Of Immune Response Cell Surface Pattern Recognition Receptor Signaling Pathway Fc Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Tumor Necrosis Factor-mediated Signaling Pathway CD40 Receptor Complex Transferrin Receptor Binding TRIF-dependent Toll-like Receptor Signaling Pathway Cytosol Scaffold Protein Binding MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway MAP Kinase Activity Regulation Of Cytokine Production Involved In Inflammatory Response TRNA Modification Protein Serine/threonine Kinase Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Immune Response Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway	Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Positive Regulation Of Multicellular Organismal Process Regulation Of Lymphocyte Activation Nucleoplasm Leukocyte Activation Involved In Immune Response B Cell Activation Involved In Immune Response DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Cell Activation Involved In Immune Response Regulation Of Cell Activation DNA-binding Transcription Factor Activity Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Isotype Switching To IgE Isotypes Isotype Switching Positive Regulation Of B Cell Activation Somatic Diversification Of Immunoglobulins Involved In Immune Response Positive Regulation Of Gene Expression B Cell Activation Regulation Of Macromolecule Metabolic Process Somatic Recombination Of Immunoglobulin Gene Segments Leukocyte Activation Chromatin Lipopolysaccharide-mediated Signaling Pathway DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Lymphocyte Activation Involved In Immune Response DNA Binding Regulation Of Gene Expression Somatic Diversification Of Immunoglobulins Negative Regulation Of RNA Metabolic Process Somatic Cell DNA Recombination Nucleus Toll Signaling Pathway Macrophage Differentiation Regulation Of B Cell Activation Regulation Of Macromolecule Biosynthetic Process Regulation Of Multicellular Organismal Process Cell Activation Positive Regulation Of Macromolecule Biosynthetic Process Interleukin-33-mediated Signaling Pathway Lymphocyte Activation Regulation Of Metabolic Process Regulation Of Primary Metabolic Process T-helper 2 Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Immune System Process Myeloid Leukocyte Differentiation Regulation Of Immune Response Negative Regulation Of Transcription By RNA Polymerase II
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