HAP1 and TOMM20

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HAP1	TOMM20
Description		huntingtin associated protein 1	translocase of outer mitochondrial membrane 20
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Mitochondrion Lysosome Endosome Early Endosome Autophagosome Endoplasmic Reticulum Centrosome Centriole Cytosol Cytoskeleton Synaptic Vesicle Actin Cytoskeleton Inclusion Body Axon Dendrite Growth Cone Cytoplasmic Vesicle Cell Projection Neuron Projection Dendritic Spine Synapse Presynapse Axon Cytoplasm	Mitochondrion Mitochondrial Envelope Mitochondrial Outer Membrane Mitochondrial Outer Membrane Translocase Complex Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Cell Periphery Sperm Midpiece Migrasome TOM Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Myosin Binding Transmembrane Transporter Binding Brain-derived Neurotrophic Factor Binding	Protein Binding Protein Transmembrane Transporter Activity Protein-transporting ATPase Activity Mitochondrion Targeting Sequence Binding Unfolded Protein Binding
	Biological Process	Protein Targeting Exocytosis Autophagy Chemical Synaptic Transmission Brain Development Anterograde Axonal Transport Retrograde Axonal Transport Intracellular Protein Localization Protein Transport Regulation Of Exocytosis Cerebellum Development Hypothalamus Cell Differentiation Neurogenesis Cell Projection Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Neurotrophin Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vesicle Transport Along Microtubule Neurotrophin TRK Receptor Signaling Pathway Mitochondrion Distribution Positive Regulation Of Neurogenesis Negative Regulation Of Amyloid-beta Formation Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Non-motile Cilium Assembly	Protein Targeting Protein Targeting To Mitochondrion Intracellular Protein Transport Protein Transport TRNA Import Into Mitochondrion Protein Import Into Mitochondrial Matrix Protein Insertion Into Mitochondrial Outer Membrane
Pathways			Mitochondrial protein import PINK1-PRKN Mediated Mitophagy Ub-specific processing proteases
Drugs
Diseases
GWAS		Developmental language disorder (syntactic complexity) ( 27016271) Esophageal cancer (squamous cell) ( 22960999)	Apolipoprotein A1 levels ( 32203549) Cholesterol, total ( 20686565) Cobalt levels ( 26025379) Immune reponse to smallpox (secreted IL-2) ( 22610502) LDL cholesterol ( 20686565) LDL cholesterol levels ( 32203549) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		93 interacting genes: AEN ANTKMT APLP1 ATP5MF BARD1 BRD7 C1orf216 C7orf25 C8orf33 CATSPERT CBX8 CCDC13 CDC73 CDK18 CDK5RAP2 CFAP263 COL9A2 CRIP1 DCTN1 DDX49 DEFB1 EIF3E FAM50B FEZ1 GABARAPL2 GADD45G GIT1 GPRASP2 HDAC4 HGS HMOX2 HOXB5 HSPA1A HSPA4 HTT IMMT ING5 KAT5 KAT7 KATNBL1 KBTBD7 KPNA2 LRIF1 LUC7L2 MPP3 MRPS9 MSGN1 NAP1L5 NDUFB9 NEUROD1 NIPSNAP3A NOD2 NOP53 PABPC4 PCM1 PDCD7 PFDN1 PKN1 PPID PPOX PPP1R18 PRPF31 PSMD11 RER1 RHPN1 RIF1 RPS10 RPS25 SCNM1 SNAPIN SRSF4 STX5 TAF1D TBP TIMM17A TNNT1 TNNT3 TOMM20 TSPYL1 UTP3 VIM ZFP1 ZMAT2 ZNF124 ZNF20 ZNF24 ZNF33B ZNF490 ZNF572 ZNF575 ZNF648 ZNF691 ZNF835	22 interacting genes: AIP APOA1 ATXN1 BAG6 BCL2 CDC73 CEP126 DHFR FBXO7 FEZ1 HAP1 HSD17B10 OTC PINK1 PPHLN1 PTN RECQL4 SNCA TOMM22 UCP1 USP40 VDAC1
Entrez ID		9001	9804
HPRD ID		02972	03507
Ensembl ID		ENSG00000173805	ENSG00000173726
Uniprot IDs		P54257	Q15388
PDB IDs			4APO 7VBY 7VC9 8XVA 9EIH 9EII 9EIJ
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Microtubule Nucleation Positive Regulation Of Microtubule Polymerization Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Localization Establishment Of Mitotic Spindle Orientation Mitotic Spindle Pole DNA Replication-dependent Chromatin Disassembly Establishment Of Spindle Orientation Regulation Of Microtubule Nucleation Chromatin Organization Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein Binding Regulation Of Metabolic Process Establishment Of Spindle Localization Positive Regulation Of Aggrephagy Protein Import Into Mitochondrial Matrix RNA Polymerase Transcription Factor SL1 Complex Histone Acetyltransferase Complex Spindle Localization Regulation Of Microtubule Polymerization Regulation Of Macromolecule Metabolic Process Establishment Of Organelle Localization Centriolar Satellite Male Pronucleus Troponin Complex Protein Acetylation Histone H4K16 Acetyltransferase Activity Gamma-tubulin Binding	Regulation Of Protein Stability Mitochondrion Organization Regulation Of Reactive Oxygen Species Metabolic Process Mitochondrion Establishment Of Protein Localization To Mitochondrion Mitochondrial Outer Membrane Neuron Projection Regeneration Regulation Of Autophagy Positive Regulation Of Mitophagy Positive Regulation Of Autophagy Of Mitochondrion Protein Targeting Protein Targeting To Mitochondrion Negative Regulation Of Autophagy Mitochondrial Transport Growth Cone Regulation Of Mitophagy Regulation Of Calcium Ion Transmembrane Transport Negative Regulation Of Metabolic Process Regulation Of Autophagy Of Mitochondrion Negative Regulation Of Neuron Apoptotic Process Establishment Of Protein Localization To Organelle Regulation Of Organelle Transport Along Microtubule Negative Regulation Of Apoptotic Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Programmed Cell Death Positive Regulation Of Type 2 Mitophagy Negative Regulation Of Catabolic Process Regulation Of Macroautophagy Negative Regulation Of Autophagosome Assembly Pore Complex Regulation Of Biological Quality Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Calcium Ion Transport Regulation Of Hydrogen Peroxide Metabolic Process Inclusion Body Positive Regulation Of Macroautophagy Regulation Of Neuron Apoptotic Process Axon Regeneration Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Cellular Response To Oxidative Stress Dopamine Transport Regulation Of Oxidative Phosphorylation Mitochondrial Transmembrane Transport Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrial Membrane Organization Cellular Localization Regulation Of Dopamine Secretion Establishment Of Localization In Cell
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