HAP1 and PPID

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HAP1	PPID
Gene Name		huntingtin-associated protein 1	peptidylprolyl isomerase D
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Lysosome Autophagic Vacuole Endoplasmic Reticulum Cytoskeleton Synaptic Vesicle Actin Cytoskeleton Inclusion Body Cell Junction Axon	Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Protein Binding Ion Channel Binding Brain-derived Neurotrophic Factor Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding Transcription Factor Binding Cyclosporin A Binding Estrogen Receptor Binding Hsp70 Protein Binding Heat Shock Protein Binding Hsp90 Protein Binding
	Biological Process	Exocytosis Autophagy Synaptic Transmission Brain Development Anterograde Axon Cargo Transport Retrograde Axon Cargo Transport Protein Localization Protein Transport Regulation Of Exocytosis Cerebellum Development Hypothalamus Cell Differentiation Cell Projection Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Neurotrophin Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vesicle Transport Along Microtubule Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Neurogenesis Negative Regulation Of Beta-amyloid Formation Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Nonmotile Primary Cilium Assembly	Negative Regulation Of Transcription From RNA Polymerase II Promoter Protein Peptidyl-prolyl Isomerization Protein Folding Protein Complex Assembly Apoptotic Process Protein Transport Viral Release From Host Cell Lipid Particle Organization Positive Regulation Of Apoptotic Process Positive Regulation Of Viral Genome Replication Positive Regulation Of Protein Secretion Chaperone-mediated Protein Folding Cellular Response To UV-A
Pathways
Drugs
Diseases
GWAS		Esophageal cancer (squamous cell) ( 22960999)
Protein-Protein Interactions		68 interactors: APLP1 ATP5J2 BARD1 BRD7 C7orf25 C8orf33 CBX8 CCDC113 CDC73 CDK5RAP2 COL9A2 CRIP1 DCTN1 DDX49 DEFB1 EIF3E FAM173A FEZ1 GADD45G GIT1 GLTSCR2 GPRASP2 HGS HMOX2 HSPA4 HTT IMMT ING5 KAT5 KAT7 KATNBL1 KBTBD7 KPNA2 LRIF1 LUC7L2 MPP3 MRPS9 NAP1L5 NDUFB9 NEUROD1 NIPSNAP3A PABPC4 PCM1 PDCD7 PFDN1 PPID PPOX PSMD11 RER1 RIF1 RPS10 RPS25 SNAPIN SRSF4 STX5 TAF1D TBP TIMM17A TNNT1 TNNT3 TOMM20 TSPYL1 UTP3 VIM ZNF20 ZNF24 ZNF33B ZNF691	20 interactors: APP BCL2 CSNK2B ESR1 FBXO25 FES HAP1 HSF1 HSP90AA1 HSP90AB1 HSPA8 KAT7 LNX1 PLK1 S100A1 S100A2 S100A6 SLC25A4 SMURF2 TRIM27
Entrez ID		9001	5481
HPRD ID		02972	11875
Ensembl ID		ENSG00000173805	ENSG00000171497
Uniprot IDs		P54257	E5KN55 Q08752
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cytoplasmic Transport Intracellular Transport Establishment Of Localization In Cell Establishment Of Protein Localization To Organelle RNA Biosynthetic Process Organelle Organization Protein Localization To Organelle Viral Process Protein Targeting Negative Regulation Of Cellular Metabolic Process Cellular Localization Regulation Of Metabolic Process Regulation Of Gene Expression Cellular Process Cellular Macromolecule Biosynthetic Process Transcription, DNA-templated Macromolecule Biosynthetic Process Mitochondrial Transport Regulation Of Nitrogen Compound Metabolic Process Intracellular Protein Transport Actin-myosin Filament Sliding Muscle Filament Sliding Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Protein Localization Biosynthetic Process Protein Transport Endosomal Transport Cellular Metabolic Process Actin-mediated Cell Contraction Protein Localization Establishment Of Protein Localization Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport MRNA Metabolic Process Chromatin Organization Cell Cycle Regulation Of Cell Cycle Protein Transmembrane Transport Actin Filament-based Movement Organelle Localization Protein Targeting To Mitochondrion Negative Regulation Of Neurogenesis	Axonogenesis Regulation Of Cellular Response To Heat Axon Development Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Cell Projection Organization Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Cellular Response To Heat Neuron Development Cellular Protein Metabolic Process Axon Guidance Cell Morphogenesis Neuron Differentiation Generation Of Neurons Regulation Of Binding Response To Heat Negative Regulation Of Cellular Metabolic Process Neurogenesis Nervous System Development Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Protein Ubiquitination Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Protein Binding Cell Development Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Chemotaxis Protein Modification By Small Protein Conjugation Protein Metabolic Process Cellular Protein Modification Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Movement Of Cell Or Subcellular Component Cellular Response To Stimulus Positive Regulation Of Cell Cycle Phase Transition Response To Temperature Stimulus Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Organelle Organization Regulation Of Calcium Ion Transport Intracellular Receptor Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process System Development Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Innate Immune Response
Tagcloud ?		autism axons cognition elucidated hippocampal huntingtin impairs knockdown morphogenesis mtorc1 neurons partner phenotypes polarity positioning profoundly proteomics pyramidal recapitulate reflected s6 specification supernumerary suppresses tsc tsc1 tsc2 tuberous uncover	accurately blastx classifications close cog degs density differentially downloaded enriched esr1 genecodis gotm gse7429 hundred includes language mapped mineral module modules nrip1 obtain omnibus osteoprotegerin packages searched software vdr
Tagcloud (Difference) ?		autism axons cognition elucidated hippocampal huntingtin impairs knockdown morphogenesis mtorc1 neurons partner phenotypes polarity positioning profoundly proteomics pyramidal recapitulate reflected s6 specification supernumerary suppresses tsc tsc1 tsc2 tuberous uncover	accurately blastx classifications close cog degs density differentially downloaded enriched esr1 genecodis gotm gse7429 hundred includes language mapped mineral module modules nrip1 obtain omnibus osteoprotegerin packages searched software vdr
Tagcloud (Intersection) ?