HAP1 and PDCD7

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HAP1	PDCD7
Gene Name		huntingtin-associated protein 1	programmed cell death 7
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Lysosome Autophagic Vacuole Endoplasmic Reticulum Cytoskeleton Synaptic Vesicle Actin Cytoskeleton Inclusion Body Cell Junction Axon	U12-type Spliceosomal Complex
	Molecular Function	Protein Binding Ion Channel Binding Brain-derived Neurotrophic Factor Binding
	Biological Process	Exocytosis Autophagy Synaptic Transmission Brain Development Anterograde Axon Cargo Transport Retrograde Axon Cargo Transport Protein Localization Protein Transport Regulation Of Exocytosis Cerebellum Development Hypothalamus Cell Differentiation Cell Projection Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Neurotrophin Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vesicle Transport Along Microtubule Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Neurogenesis Negative Regulation Of Beta-amyloid Formation Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Nonmotile Primary Cilium Assembly	Apoptotic Process RNA Splicing Response To Glucocorticoid Positive Regulation Of T Cell Apoptotic Process Positive Regulation Of Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Esophageal cancer (squamous cell) ( 22960999)
Protein-Protein Interactions		68 interactors: APLP1 ATP5J2 BARD1 BRD7 C7orf25 C8orf33 CBX8 CCDC113 CDC73 CDK5RAP2 COL9A2 CRIP1 DCTN1 DDX49 DEFB1 EIF3E FAM173A FEZ1 GADD45G GIT1 GLTSCR2 GPRASP2 HGS HMOX2 HSPA4 HTT IMMT ING5 KAT5 KAT7 KATNBL1 KBTBD7 KPNA2 LRIF1 LUC7L2 MPP3 MRPS9 NAP1L5 NDUFB9 NEUROD1 NIPSNAP3A PABPC4 PCM1 PDCD7 PFDN1 PPID PPOX PSMD11 RER1 RIF1 RPS10 RPS25 SNAPIN SRSF4 STX5 TAF1D TBP TIMM17A TNNT1 TNNT3 TOMM20 TSPYL1 UTP3 VIM ZNF20 ZNF24 ZNF33B ZNF691	6 interactors: APP CALM1 FEZ1 FEZ2 HAP1 PRPF40A
Entrez ID		9001	10081
HPRD ID		02972	09736
Ensembl ID		ENSG00000173805	ENSG00000090470
Uniprot IDs		P54257	Q6IEG3 Q8N8D1
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cytoplasmic Transport Intracellular Transport Establishment Of Localization In Cell Establishment Of Protein Localization To Organelle RNA Biosynthetic Process Organelle Organization Protein Localization To Organelle Viral Process Protein Targeting Negative Regulation Of Cellular Metabolic Process Cellular Localization Regulation Of Metabolic Process Regulation Of Gene Expression Cellular Process Cellular Macromolecule Biosynthetic Process Transcription, DNA-templated Macromolecule Biosynthetic Process Mitochondrial Transport Regulation Of Nitrogen Compound Metabolic Process Intracellular Protein Transport Actin-myosin Filament Sliding Muscle Filament Sliding Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Protein Localization Biosynthetic Process Protein Transport Endosomal Transport Cellular Metabolic Process Actin-mediated Cell Contraction Protein Localization Establishment Of Protein Localization Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport MRNA Metabolic Process Chromatin Organization Cell Cycle Regulation Of Cell Cycle Protein Transmembrane Transport Actin Filament-based Movement Organelle Localization Protein Targeting To Mitochondrion Negative Regulation Of Neurogenesis	Regulation Of Cell Cycle Process Movement Of Cell Or Subcellular Component Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Cation Channel Activity Regulation Of Cell Cycle Nervous System Development Exocytosis Positive Regulation Of Ion Transmembrane Transporter Activity Axon Cargo Transport Cell Projection Organization Positive Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Transporter Activity Axon Guidance Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cytokinesis Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Locomotion Platelet Degranulation Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Cation Channel Activity Regulation Of Cell Morphogenesis Positive Regulation Of Ion Transmembrane Transport Regulation Of ERBB Signaling Pathway Secretion By Cell Axonogenesis Positive Regulation Of Calcium Ion Transport Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Generation Of Neurons Axon Development Cellular Response To Growth Factor Stimulus Cell Morphogenesis Involved In Neuron Differentiation Response To Growth Factor Chemotaxis Neurogenesis Positive Regulation Of Mitotic Cell Cycle Secretion Regulation Of Receptor Activity Neuron Projection Morphogenesis Response To External Stimulus Microtubule-based Transport Regulation Of Neurogenesis Synaptic Growth At Neuromuscular Junction Cytoskeleton-dependent Intracellular Transport Cell Morphogenesis Involved In Differentiation Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Brain Development Establishment Of Localization In Cell
Tagcloud ?		autism axons cognition elucidated hippocampal huntingtin impairs knockdown morphogenesis mtorc1 neurons partner phenotypes polarity positioning profoundly proteomics pyramidal recapitulate reflected s6 specification supernumerary suppresses tsc tsc1 tsc2 tuberous uncover	accurate aml amlcg ang2 atcay ca6 cn courses cr cytogenetically discriminated fam3a fis1 german ggt5 hence improving increasingly klrf1 numerous os predicting prediction prognosis published rfs seem shorter unsatisfied
Tagcloud (Difference) ?		autism axons cognition elucidated hippocampal huntingtin impairs knockdown morphogenesis mtorc1 neurons partner phenotypes polarity positioning profoundly proteomics pyramidal recapitulate reflected s6 specification supernumerary suppresses tsc tsc1 tsc2 tuberous uncover	accurate aml amlcg ang2 atcay ca6 cn courses cr cytogenetically discriminated fam3a fis1 german ggt5 hence improving increasingly klrf1 numerous os predicting prediction prognosis published rfs seem shorter unsatisfied
Tagcloud (Intersection) ?