HAP1 and KBTBD7

Number of citations of the paper that reports this interaction (PubMedID 15383276)
0

Data Source:
BioGRID (two hybrid)

		HAP1	KBTBD7
Description		huntingtin associated protein 1	kelch repeat and BTB domain containing 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Mitochondrion Lysosome Endosome Early Endosome Autophagosome Endoplasmic Reticulum Centrosome Centriole Cytosol Cytoskeleton Synaptic Vesicle Actin Cytoskeleton Inclusion Body Axon Dendrite Growth Cone Cytoplasmic Vesicle Cell Projection Neuron Projection Dendritic Spine Synapse Presynapse Axon Cytoplasm	Nucleus Cytoplasm Cytosol Cul3-RING Ubiquitin Ligase Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Myosin Binding Transmembrane Transporter Binding Brain-derived Neurotrophic Factor Binding	Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Protein Targeting Exocytosis Autophagy Chemical Synaptic Transmission Brain Development Anterograde Axonal Transport Retrograde Axonal Transport Intracellular Protein Localization Protein Transport Regulation Of Exocytosis Cerebellum Development Hypothalamus Cell Differentiation Neurogenesis Cell Projection Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Neurotrophin Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vesicle Transport Along Microtubule Neurotrophin TRK Receptor Signaling Pathway Mitochondrion Distribution Positive Regulation Of Neurogenesis Negative Regulation Of Amyloid-beta Formation Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Non-motile Cilium Assembly	Negative Regulation Of Signal Transduction Protein Ubiquitination Regulation Of Rac Protein Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination
Pathways			Regulation of RAS by GAPs Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Developmental language disorder (syntactic complexity) ( 27016271) Esophageal cancer (squamous cell) ( 22960999)
Interacting Genes		93 interacting genes: AEN ANTKMT APLP1 ATP5MF BARD1 BRD7 C1orf216 C7orf25 C8orf33 CATSPERT CBX8 CCDC13 CDC73 CDK18 CDK5RAP2 CFAP263 COL9A2 CRIP1 DCTN1 DDX49 DEFB1 EIF3E FAM50B FEZ1 GABARAPL2 GADD45G GIT1 GPRASP2 HDAC4 HGS HMOX2 HOXB5 HSPA1A HSPA4 HTT IMMT ING5 KAT5 KAT7 KATNBL1 KBTBD7 KPNA2 LRIF1 LUC7L2 MPP3 MRPS9 MSGN1 NAP1L5 NDUFB9 NEUROD1 NIPSNAP3A NOD2 NOP53 PABPC4 PCM1 PDCD7 PFDN1 PKN1 PPID PPOX PPP1R18 PRPF31 PSMD11 RER1 RHPN1 RIF1 RPS10 RPS25 SCNM1 SNAPIN SRSF4 STX5 TAF1D TBP TIMM17A TNNT1 TNNT3 TOMM20 TSPYL1 UTP3 VIM ZFP1 ZMAT2 ZNF124 ZNF20 ZNF24 ZNF33B ZNF490 ZNF572 ZNF575 ZNF648 ZNF691 ZNF835	20 interacting genes: BARD1 BLMH C8orf33 CCDC106 CPT1A DRD2 DUSP23 GABARAP GABARAPL1 GABARAPL2 HAP1 KLF15 LRIF1 MAP1LC3B MAP1LC3C MEOX2 NFKBIE PHC2 PSME3 VANGL2
Entrez ID		9001	84078
HPRD ID		02972	13759
Ensembl ID		ENSG00000173805	ENSG00000120696
Uniprot IDs		P54257	Q8WVZ9
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Microtubule Nucleation Positive Regulation Of Microtubule Polymerization Regulation Of Primary Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Localization Establishment Of Mitotic Spindle Orientation Mitotic Spindle Pole DNA Replication-dependent Chromatin Disassembly Establishment Of Spindle Orientation Regulation Of Microtubule Nucleation Chromatin Organization Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein Binding Regulation Of Metabolic Process Establishment Of Spindle Localization Positive Regulation Of Aggrephagy Protein Import Into Mitochondrial Matrix RNA Polymerase Transcription Factor SL1 Complex Histone Acetyltransferase Complex Spindle Localization Regulation Of Microtubule Polymerization Regulation Of Macromolecule Metabolic Process Establishment Of Organelle Localization Centriolar Satellite Male Pronucleus Troponin Complex Protein Acetylation Histone H4K16 Acetyltransferase Activity Gamma-tubulin Binding	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Autophagosome Autophagosome Maturation Autophagosome Membrane Mitophagy Autophagy Of Mitochondrion Autophagy Autophagosome Assembly Autophagosome Organization Phospholipid Binding Protein-containing Complex Disassembly GABA Receptor Binding Macroautophagy Vacuole Organization Cellular Response To Starvation Response To Starvation Cellular Response To Nutrient Levels Organelle Assembly Response To Nutrient Levels Beta-tubulin Binding Ubiquitin Protein Ligase Binding Catabolic Process Cytoplasmic Vesicle Microtubule Regulation Of Synaptic Transmission, GABAergic Regulation Of Protein Catabolic Process Negative Regulation Of MRNA 3'-end Processing Positive Regulation Of Neurotrophin Production Response To Stress Organelle Membrane Long-chain Fatty Acid Transport
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