HAP1 and KBTBD7

Number of citations of the paper that reports this interaction (PMID 15383276)
99

Data Source:
BioGRID (two hybrid)

		HAP1	KBTBD7
Gene Name		huntingtin-associated protein 1	kelch repeat and BTB (POZ) domain containing 7
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Lysosome Autophagic Vacuole Endoplasmic Reticulum Cytoskeleton Synaptic Vesicle Actin Cytoskeleton Inclusion Body Cell Junction Axon	Cellular_component
	Molecular Function	Protein Binding Ion Channel Binding Brain-derived Neurotrophic Factor Binding	Molecular_function Protein Binding
	Biological Process	Exocytosis Autophagy Synaptic Transmission Brain Development Anterograde Axon Cargo Transport Retrograde Axon Cargo Transport Protein Localization Protein Transport Regulation Of Exocytosis Cerebellum Development Hypothalamus Cell Differentiation Cell Projection Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Neurotrophin Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vesicle Transport Along Microtubule Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Neurogenesis Negative Regulation Of Beta-amyloid Formation Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Nonmotile Primary Cilium Assembly	Biological_process
Pathways
Drugs
Diseases
GWAS		Esophageal cancer (squamous cell) ( 22960999)
Protein-Protein Interactions		68 interactors: APLP1 ATP5J2 BARD1 BRD7 C7orf25 C8orf33 CBX8 CCDC113 CDC73 CDK5RAP2 COL9A2 CRIP1 DCTN1 DDX49 DEFB1 EIF3E FAM173A FEZ1 GADD45G GIT1 GLTSCR2 GPRASP2 HGS HMOX2 HSPA4 HTT IMMT ING5 KAT5 KAT7 KATNBL1 KBTBD7 KPNA2 LRIF1 LUC7L2 MPP3 MRPS9 NAP1L5 NDUFB9 NEUROD1 NIPSNAP3A PABPC4 PCM1 PDCD7 PFDN1 PPID PPOX PSMD11 RER1 RIF1 RPS10 RPS25 SNAPIN SRSF4 STX5 TAF1D TBP TIMM17A TNNT1 TNNT3 TOMM20 TSPYL1 UTP3 VIM ZNF20 ZNF24 ZNF33B ZNF691	13 interactors: BARD1 BLMH C8orf33 CPT1A DUSP23 GABARAPL1 GABARAPL2 HAP1 LINC00341 LRIF1 MAP1LC3B NFKBIE PHC2
Entrez ID		9001	84078
HPRD ID		02972	13759
Ensembl ID		ENSG00000173805
Uniprot IDs		P54257	Q8WVZ9
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cytoplasmic Transport Intracellular Transport Establishment Of Localization In Cell Establishment Of Protein Localization To Organelle RNA Biosynthetic Process Organelle Organization Protein Localization To Organelle Viral Process Protein Targeting Negative Regulation Of Cellular Metabolic Process Cellular Localization Regulation Of Metabolic Process Regulation Of Gene Expression Cellular Process Cellular Macromolecule Biosynthetic Process Transcription, DNA-templated Macromolecule Biosynthetic Process Mitochondrial Transport Regulation Of Nitrogen Compound Metabolic Process Intracellular Protein Transport Actin-myosin Filament Sliding Muscle Filament Sliding Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Protein Localization Biosynthetic Process Protein Transport Endosomal Transport Cellular Metabolic Process Actin-mediated Cell Contraction Protein Localization Establishment Of Protein Localization Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport MRNA Metabolic Process Chromatin Organization Cell Cycle Regulation Of Cell Cycle Protein Transmembrane Transport Actin Filament-based Movement Organelle Localization Protein Targeting To Mitochondrion Negative Regulation Of Neurogenesis	Nucleophagy Mitochondrion Degradation Autophagy Organelle Disassembly Autophagic Vacuole Assembly Macroautophagy Vacuole Organization Membrane Fusion Cellular Response To Nitrogen Starvation Cellular Response To Starvation Cellular Response To Nutrient Levels Response To Starvation Cellular Response To Extracellular Stimulus Cellular Response To Stress Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Mitochondrion Organization Catabolic Process Negative Regulation Of Intracellular Protein Transport Response To Nutrient Levels Regulation Of Cellular Localization Regulation Of Intracellular Transport D-serine Transport Negative Regulation Of MRNA 3'-end Processing Response To Extracellular Stimulus Organelle Assembly Negative Regulation Of Intracellular Transport Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Cilium Assembly Response To Drug Regulation Of Protein Transport Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Polyubiquitination Negative Regulation Of Protein Export From Nucleus Regulation Of Establishment Of Protein Localization Negative Regulation Of Protein Transport Protein K6-linked Ubiquitination Positive Regulation Of Fatty Acid Beta-oxidation Carnitine Shuttle Regulation Of Nucleocytoplasmic Transport Hypothalamus Cell Differentiation Negative Regulation Of Beta-amyloid Formation Regulation Of Protein Localization Retrograde Axon Cargo Transport Carnitine Transmembrane Transport Carnitine Transport Membrane Organization Regulation Of Intracellular Protein Transport Negative Regulation Of Amyloid Precursor Protein Catabolic Process
Tagcloud ?		autism axons cognition elucidated hippocampal huntingtin impairs knockdown morphogenesis mtorc1 neurons partner phenotypes polarity positioning profoundly proteomics pyramidal recapitulate reflected s6 specification supernumerary suppresses tsc tsc1 tsc2 tuberous uncover
Tagcloud (Difference) ?		autism axons cognition elucidated hippocampal huntingtin impairs knockdown morphogenesis mtorc1 neurons partner phenotypes polarity positioning profoundly proteomics pyramidal recapitulate reflected s6 specification supernumerary suppresses tsc tsc1 tsc2 tuberous uncover
Tagcloud (Intersection) ?