HAP1 and ATP5J2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		HAP1	ATP5J2
Gene Name		huntingtin-associated protein 1	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Lysosome Autophagic Vacuole Endoplasmic Reticulum Cytoskeleton Synaptic Vesicle Actin Cytoskeleton Inclusion Body Cell Junction Axon	Nucleus Mitochondrial Inner Membrane Mitochondrial Proton-transporting ATP Synthase Complex Integral Component Of Membrane Proton-transporting ATP Synthase Complex, Coupling Factor F(o) Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Ion Channel Binding Brain-derived Neurotrophic Factor Binding	ATPase Activity Transmembrane Transporter Activity
	Biological Process	Exocytosis Autophagy Synaptic Transmission Brain Development Anterograde Axon Cargo Transport Retrograde Axon Cargo Transport Protein Localization Protein Transport Regulation Of Exocytosis Cerebellum Development Hypothalamus Cell Differentiation Cell Projection Organization Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Positive Regulation Of Synaptic Transmission, GABAergic Positive Regulation Of Neurotrophin Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Vesicle Transport Along Microtubule Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Neurogenesis Negative Regulation Of Beta-amyloid Formation Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Nonmotile Primary Cilium Assembly	Proton Transport Respiratory Electron Transport Chain Mitochondrial ATP Synthesis Coupled Proton Transport Cellular Metabolic Process Small Molecule Metabolic Process
Pathways			Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. The citric acid (TCA) cycle and respiratory electron transport Formation of ATP by chemiosmotic coupling
Drugs
Diseases
GWAS		Esophageal cancer (squamous cell) ( 22960999)
Protein-Protein Interactions		68 interactors: APLP1 ATP5J2 BARD1 BRD7 C7orf25 C8orf33 CBX8 CCDC113 CDC73 CDK5RAP2 COL9A2 CRIP1 DCTN1 DDX49 DEFB1 EIF3E FAM173A FEZ1 GADD45G GIT1 GLTSCR2 GPRASP2 HGS HMOX2 HSPA4 HTT IMMT ING5 KAT5 KAT7 KATNBL1 KBTBD7 KPNA2 LRIF1 LUC7L2 MPP3 MRPS9 NAP1L5 NDUFB9 NEUROD1 NIPSNAP3A PABPC4 PCM1 PDCD7 PFDN1 PPID PPOX PSMD11 RER1 RIF1 RPS10 RPS25 SNAPIN SRSF4 STX5 TAF1D TBP TIMM17A TNNT1 TNNT3 TOMM20 TSPYL1 UTP3 VIM ZNF20 ZNF24 ZNF33B ZNF691	13 interactors: ARL8B CAPNS1 CCDC137 CRELD1 FBP1 HAP1 KDM1A LPP NDUFA6 PRPF4 PVRL2 RPLP1 ZFPL1
Entrez ID		9001	9551
HPRD ID		02972	16520
Ensembl ID		ENSG00000173805	ENSG00000241468
Uniprot IDs		P54257	P56134
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cytoplasmic Transport Intracellular Transport Establishment Of Localization In Cell Establishment Of Protein Localization To Organelle RNA Biosynthetic Process Organelle Organization Protein Localization To Organelle Viral Process Protein Targeting Negative Regulation Of Cellular Metabolic Process Cellular Localization Regulation Of Metabolic Process Regulation Of Gene Expression Cellular Process Cellular Macromolecule Biosynthetic Process Transcription, DNA-templated Macromolecule Biosynthetic Process Mitochondrial Transport Regulation Of Nitrogen Compound Metabolic Process Intracellular Protein Transport Actin-myosin Filament Sliding Muscle Filament Sliding Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Cellular Protein Localization Biosynthetic Process Protein Transport Endosomal Transport Cellular Metabolic Process Actin-mediated Cell Contraction Protein Localization Establishment Of Protein Localization Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport MRNA Metabolic Process Chromatin Organization Cell Cycle Regulation Of Cell Cycle Protein Transmembrane Transport Actin Filament-based Movement Organelle Localization Protein Targeting To Mitochondrion Negative Regulation Of Neurogenesis	Demethylation Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Regulation Of Primitive Erythrocyte Differentiation Coreceptor-mediated Virion Attachment To Host Cell Diencephalon Development Sperm Mitochondrion Organization Susceptibility To T Cell Mediated Cytotoxicity Positive Regulation Of Cilium Assembly Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Fusion Of Virus Membrane With Host Plasma Membrane
Tagcloud ?		autism axons cognition elucidated hippocampal huntingtin impairs knockdown morphogenesis mtorc1 neurons partner phenotypes polarity positioning profoundly proteomics pyramidal recapitulate reflected s6 specification supernumerary suppresses tsc tsc1 tsc2 tuberous uncover	angptl4 atp5d atp5g3 atp5l ccnb1 cdc10 cdc20 cdc23 dyn efemp1 eng epas1 fbn1 fn1 hcaecs hmox1 itga5 itgae itgav lamr1 lgals3 loxl2 lss p4hb pgk1 pkd2 sage vasodilatory vasoreactive
Tagcloud (Difference) ?		autism axons cognition elucidated hippocampal huntingtin impairs knockdown morphogenesis mtorc1 neurons partner phenotypes polarity positioning profoundly proteomics pyramidal recapitulate reflected s6 specification supernumerary suppresses tsc tsc1 tsc2 tuberous uncover	angptl4 atp5d atp5g3 atp5l ccnb1 cdc10 cdc20 cdc23 dyn efemp1 eng epas1 fbn1 fn1 hcaecs hmox1 itga5 itgae itgav lamr1 lgals3 loxl2 lss p4hb pgk1 pkd2 sage vasodilatory vasoreactive
Tagcloud (Intersection) ?