EHMT1 and TRIM15

Number of citations of the paper that reports this interaction (PMID 20211142)
148

Data Source:
BioGRID (two hybrid)

		EHMT1	TRIM15
Gene Name		euchromatic histone-lysine N-methyltransferase 1	tripartite motif containing 15
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Plasma Membrane	Intracellular
	Molecular Function	P53 Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Protein-lysine N-methyltransferase Activity Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K9 Specific) Histone Methyltransferase Activity (H3-K27 Specific) C2H2 Zinc Finger Domain Binding	Zinc Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter DNA Methylation Chromatin Organization Embryo Development Chromatin Modification Histone Methylation Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Negative Regulation Of Transcription, DNA-templated Histone H3-K9 Methylation Histone H3-K27 Methylation	Mesodermal Cell Fate Determination Positive Regulation Of Type I Interferon Production Innate Immune Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of RIG-I Signaling Pathway Negative Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Viral Release From Host Cell
Pathways		Chromatin modifying enzymes Chromatin organization PKMTs methylate histone lysines Cellular Senescence Senescence-Associated Secretory Phenotype (SASP)
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: ATXN1 DNMT3A EED EZH2 HIST1H3A HIST3H3 LZTR1 PCBD1 TP53 TRIM15 UBC WIZ	14 interactors: ACD EHMT1 FAM151B FAM161A GTF2E1 IRF5 MED7 MYBL2 RABGEF1 SNW1 TAF9B TINF2 TRIM8 UBE2U
Entrez ID		79813	89870
HPRD ID		07383	15551
Ensembl ID		ENSG00000181090	ENSG00000204610
Uniprot IDs		Q9H9B1	Q5SRL0 Q9C019
PDB IDs		2IGQ 2RFI 3B7B 3B95 3FPD 3HNA 3MO0 3MO2 3MO5 3SW9 3SWC 4I51
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression, Epigenetic DNA Methylation Chromosome Organization DNA Metabolic Process DNA Modification Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Chromatin Organization DNA Methylation On Cytosine Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Methylation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Cellular Metabolic Process Regulation Of Gene Expression By Genetic Imprinting Cellular Nitrogen Compound Metabolic Process Chromatin Silencing Genetic Imprinting Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Nitrogen Compound Metabolic Process Positive Regulation Of Cell Cycle DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Involved In Mitotic G1 DNA Damage Checkpoint Signal Transduction Involved In DNA Damage Checkpoint Signal Transduction Involved In Cell Cycle Checkpoint Rhythmic Process Transcription, DNA-templated Positive Regulation Of Metabolic Process	Transcription Initiation From RNA Polymerase II Promoter Telomere Assembly Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase DNA-templated Transcription, Initiation Negative Regulation Of Telomere Maintenance Nucleobase-containing Compound Metabolic Process Regulation Of Telomere Maintenance Via Telomerase Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Regulation Of Telomere Maintenance Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Protein Localization To Chromosome Regulation Of Metabolic Process Regulation Of Chromosome Organization Regulation Of Transcription From RNA Polymerase II Promoter Cellular Metabolic Process Negative Regulation Of DNA Replication Transcription Elongation From RNA Polymerase II Promoter Negative Regulation Of Protein ADP-ribosylation Positive Regulation Of Single-stranded Telomeric DNA Binding Negative Regulation Of Kit Signaling Pathway Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Viral Transcription Transcription, DNA-templated Regulation Of RNA Metabolic Process Telomere Maintenance RNA Biosynthetic Process DNA-templated Transcription, Elongation Negative Regulation Of Chromosome Organization Regulation Of Protein ADP-ribosylation Positive Regulation Of Vitamin D Receptor Signaling Pathway Negative Regulation Of DNA Metabolic Process Regulation Of Gene Expression Chromosome Organization DNA Metabolic Process Interferon-gamma-mediated Signaling Pathway Negative Regulation Of Protein Glycosylation Regulation Of DNA Replication Negative Regulation Of RNA Biosynthetic Process Regulation Of Cellular Component Organization Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Mast Cell Degranulation
Tagcloud ?		16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 magi2 mef2c microdeletions microduplications scn2a spasms stxbp1 xq28
Tagcloud (Difference) ?		16p12 2q24 5q14 9q34 aetiology caln1 cdkl5 cgh cnv cnvs counselling encephalopathies encompassing epileptic etiological grin2a hypsarrhythmia infantile intronic iss kcnq2 magi2 mef2c microdeletions microduplications scn2a spasms stxbp1 xq28
Tagcloud (Intersection) ?