EHMT1

Description		euchromatic histone lysine methyltransferase 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Nuclear Body
	Molecular Function	Transcription Corepressor Binding P53 Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3K27 Methyltransferase Activity C2H2 Zinc Finger Domain Binding Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Methylation Epigenetic Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Response To Fungicide Positive Regulation Of Cold-induced Thermogenesis Facultative Heterochromatin Formation
Pathways		Senescence-Associated Secretory Phenotype (SASP) PKMTs methylate histone lysines Regulation of TP53 Activity through Methylation Transcriptional Regulation by VENTX Transcriptional Regulation by E2F6 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex
Drugs
Diseases		Kleefstra syndrome; 9q Subtelomeric deletion syndrome
GWAS		Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Metabolite levels ( 23823483)
Interacting Genes		13 interacting genes: ATXN1 DNMT3A EED EZH2 H3-4 H3C1 LIG1 LZTR1 PCBD1 SUMO2 TP53 TRIM15 WIZ
Entrez ID		79813
HPRD ID		07383
Ensembl ID		ENSG00000181090
Uniprot IDs		A0A1B0GUD1 A0A1B0GV09 Q9H9B1
PDB IDs		2IGQ 2RFI 3B7B 3B95 3FPD 3HNA 3MO0 3MO2 3MO5 3SW9 3SWC 4I51 5TTG 5TUZ 5V9J 5VSD 5VSF 6BY9 6MBO 6MBP 7T7M 8XPT
Enriched GO Terms of Interacting Partners?		Epigenetic Regulation Of Gene Expression Nucleoplasm Chromatin Remodeling Transcription Corepressor Binding Pronucleus Chromatin Binding Chromatin Organization Cellular Response To Antibiotic Chromatin Silencing Complex Nucleus ESC/E(Z) Complex Regulation Of Gliogenesis Facultative Heterochromatin Formation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromosome Regulatory NcRNA-mediated Heterochromatin Formation Genomic Imprinting Nuclear Matrix Heterochromatin Formation Regulation Of RNA Metabolic Process LncRNA Binding Negative Regulation Of Gene Expression, Epigenetic Epigenetic Programming Of Gene Expression Regulation Of Gene Expression Nucleosome Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process DNA Binding DNA Methylation-dependent Constitutive Heterochromatin Formation Response To Antibiotic Regulation Of Glial Cell Proliferation Negative Regulation Of Transcription By RNA Polymerase II Heterochromatin Hepatocyte Homeostasis Okazaki Fragment Processing Involved In Mitotic DNA Replication Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Constitutive Heterochromatin Formation Regulation Of Transcription By RNA Polymerase II Protein-cysteine Methyltransferase Activity Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Promoter-specific Chromatin Binding Cellular Response To Trichostatin A Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle DNA Replication, Okazaki Fragment Processing 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity
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