EHMT1 and DNMT3A

Number of citations of the paper that reports this interaction (PubMedID 22086334)
52

Data Source:
BioGRID (enzymatic study)

		EHMT1	DNMT3A
Description		euchromatic histone lysine methyltransferase 1	DNA methyltransferase 3 alpha
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Nuclear Body	Chromosome, Centromeric Region Euchromatin Heterochromatin XY Body Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Matrix Catalytic Complex
	Molecular Function	Transcription Corepressor Binding P53 Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Protein-lysine N-methyltransferase Activity Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H3K9 Methyltransferase Activity Histone H3K27 Methyltransferase Activity C2H2 Zinc Finger Domain Binding Histone H3 Methyltransferase Activity Histone H3K9me2 Methyltransferase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Chromatin Binding Transcription Corepressor Activity DNA (cytosine-5-)-methyltransferase Activity Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Identical Protein Binding Unmethylated CpG Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding LncRNA Binding Protein-cysteine Methyltransferase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Peptidyl-lysine Monomethylation Peptidyl-lysine Dimethylation Methylation Epigenetic Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Response To Fungicide Positive Regulation Of Cold-induced Thermogenesis Facultative Heterochromatin Formation	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization DNA Methylation-dependent Constitutive Heterochromatin Formation Spermatogenesis Response To Xenobiotic Stimulus Response To Toxic Substance Post-embryonic Development Response To Ionizing Radiation Response To Lead Ion Regulation Of Gene Expression Neuron Differentiation Regulatory NcRNA-mediated Heterochromatin Formation Heterochromatin Formation Response To Nutrient Levels Methylation Response To Estradiol Response To Vitamin A Response To Cocaine Epigenetic Programming Of Gene Expression Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Response To Ethanol Negative Regulation Of DNA-templated Transcription Cellular Response To Amino Acid Stimulus Cellular Response To Ethanol Cellular Response To Hypoxia Genomic Imprinting Hepatocyte Apoptotic Process Autosome Genomic Imprinting Transposable Element Silencing By PiRNA-mediated DNA Methylation Positive Regulation Of Cellular Response To Hypoxia Cellular Response To Bisphenol A
Pathways		Senescence-Associated Secretory Phenotype (SASP) PKMTs methylate histone lysines Regulation of TP53 Activity through Methylation Transcriptional Regulation by VENTX Transcriptional Regulation by E2F6 Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex	PRC2 methylates histones and DNA RMTs methylate histone arginines SUMOylation of DNA methylation proteins DNA methylation Defective pyroptosis Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs)
Drugs			Procaine Decitabine
Diseases		Kleefstra syndrome; 9q Subtelomeric deletion syndrome
GWAS		Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Metabolite levels ( 23823483)	A body shape index ( 34021172) Appendicular lean mass ( 33097823) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 21102463 28067908) Heel bone mineral density ( 30598549) Height ( 25282103 31562340 28552196 18391951 25429064) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Inflammatory bowel disease ( 28067908) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Macular thickness ( 30535121) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 32888494 27863252) Resistant hypertension ( 31545351) Type 1 diabetes ( 21980299) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		13 interacting genes: ATXN1 DNMT3A EED EZH2 H3-4 H3C1 LIG1 LZTR1 PCBD1 SUMO2 TP53 TRIM15 WIZ	35 interacting genes: CBX1 CDH1 DDB1 DNMT1 DNMT3B DNMT3L EED EEF1A1 EHMT1 EHMT2 EZH2 F8A1 H3C6 HDAC1 MDFI MEOX2 MYC NRIP1 NUP153 PIAS1 PIAS2 PRMT5 PTGES3 SETDB1 SP100 SPI1 SUV39H1 TERF2IP TP53 UBE2I UHRF1 USP7 ZBTB17 ZBTB18 ZNF513
Entrez ID		79813	1788
HPRD ID		07383	04141
Ensembl ID		ENSG00000181090	ENSG00000119772
Uniprot IDs		A0A1B0GUD1 A0A1B0GV09 Q9H9B1	A0A0C4DG02 F8WE91 Q59HC6 Q9Y6K1
PDB IDs		2IGQ 2RFI 3B7B 3B95 3FPD 3HNA 3MO0 3MO2 3MO5 3SW9 3SWC 4I51 5TTG 5TUZ 5V9J 5VSD 5VSF 6BY9 6MBO 6MBP 7T7M 8XPT	2QRV 3A1A 3A1B 3LLR 3SVM 4QBQ 4QBR 4QBS 4U7P 4U7T 5YX2 6BRR 6F57 6PA7 6W89 6W8B 6W8D 6W8J 8BA5 8QZM 8TDR 8TE1 8TE3 8TE4 8U5H 8UW1
Enriched GO Terms of Interacting Partners?		Epigenetic Regulation Of Gene Expression Nucleoplasm Chromatin Remodeling Transcription Corepressor Binding Pronucleus Chromatin Binding Chromatin Organization Cellular Response To Antibiotic Chromatin Silencing Complex Nucleus ESC/E(Z) Complex Regulation Of Gliogenesis Facultative Heterochromatin Formation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Chromosome Regulatory NcRNA-mediated Heterochromatin Formation Genomic Imprinting Nuclear Matrix Heterochromatin Formation Regulation Of RNA Metabolic Process LncRNA Binding Negative Regulation Of Gene Expression, Epigenetic Epigenetic Programming Of Gene Expression Regulation Of Gene Expression Nucleosome Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process DNA Binding DNA Methylation-dependent Constitutive Heterochromatin Formation Response To Antibiotic Regulation Of Glial Cell Proliferation Negative Regulation Of Transcription By RNA Polymerase II Heterochromatin Hepatocyte Homeostasis Okazaki Fragment Processing Involved In Mitotic DNA Replication Negative Regulation Of Helicase Activity Negative Regulation Of G1 To G0 Transition Constitutive Heterochromatin Formation Regulation Of Transcription By RNA Polymerase II Protein-cysteine Methyltransferase Activity Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Promoter-specific Chromatin Binding Cellular Response To Trichostatin A Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle DNA Replication, Okazaki Fragment Processing 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity	Epigenetic Regulation Of Gene Expression Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Heterochromatin Formation Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Chromatin Organization Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Nucleus DNA Methylation-dependent Constitutive Heterochromatin Formation Nucleoplasm Histone H3 Methyltransferase Activity Heterochromatin Constitutive Heterochromatin Formation Histone Methyltransferase Activity Regulation Of Transcription By RNA Polymerase II Methylation Negative Regulation Of Gene Expression Histone H3K9me2 Methyltransferase Activity Methyltransferase Activity Nuclear Body Histone H3K9 Methyltransferase Activity DNA Binding P53 Binding Epigenetic Programming Of Gene Expression Promoter-specific Chromatin Binding Transcription Corepressor Activity Positive Regulation Of Metabolic Process Chromatin Facultative Heterochromatin Formation Rhythmic Process Core Promoter Sequence-specific DNA Binding Transcription Corepressor Binding Chromosome
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