GTF2E1 and GTF2H4

Number of citations of the paper that reports this interaction (PMID 11113176)
6

Data Source:
HPRD (in vitro)

		GTF2E1	GTF2H4
Gene Name		general transcription factor IIE, polypeptide 1, alpha 56kDa	general transcription factor IIH, polypeptide 4, 52kDa
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Intermediate Filament Cytoskeleton	Core TFIIH Complex Nucleoplasm Holo TFIIH Complex
	Molecular Function	Protein Binding Sequence-specific DNA Binding Metal Ion Binding	Sequence-specific DNA Binding Transcription Factor Activity ATP-dependent DNA Helicase Activity Protein Kinase Activity Protein Binding DNA-dependent ATPase Activity RNA Polymerase II Carboxy-terminal Domain Kinase Activity
	Biological Process	Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process	Nucleotide-excision Repair, DNA Damage Removal DNA Repair Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Transcription From RNA Polymerase II Promoter Transcription Initiation From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter 7-methylguanosine MRNA Capping Protein Phosphorylation Gene Expression Viral Process DNA Duplex Unwinding Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Viral Transcription
Pathways		RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription HIV Infection RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle HIV Life Cycle HIV Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Polymerase II HIV Promoter Escape RNA Polymerase II Transcription Initiation Transcription of the HIV genome	RNA Polymerase II Promoter Escape Formation of HIV-1 elongation complex containing HIV-1 Tat Nucleotide Excision Repair RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Chain Elongation RNA Polymerase II Transcription RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Clearance HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Formation of transcription-coupled NER (TC-NER) repair complex RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II Pre-transcription Events Dual incision reaction in TC-NER NoRC negatively regulates rRNA expression HIV Transcription Initiation HIV Life Cycle RNA Pol II CTD phosphorylation and interaction with CE RNA Polymerase II HIV Promoter Escape HIV Transcription Elongation Dual incision reaction in GG-NER mRNA Capping RNA Polymerase I Transcription RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination Epigenetic regulation of gene expression Negative epigenetic regulation of rRNA expression Late Phase of HIV Life Cycle Formation of RNA Pol II elongation complex Global Genomic NER (GG-NER) RNA Polymerase II Transcription Initiation And Promoter Clearance Transcription-coupled NER (TC-NER) Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of incision complex in GG-NER RNA Polymerase II Transcription Initiation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Ulcerative colitis ( 20848476)
Protein-Protein Interactions		28 interactors: AES APP CBFA2T2 CDK7 ERCC3 GTF2A1 GTF2A2 GTF2B GTF2E2 GTF2F2 GTF2H1 GTF2H4 IKBKG MDM2 PCBD2 POLR2A SND1 SRPK2 TAF1 TAF11 TAF6 TBP TCEA1 TRIM15 TRIM24 TRIM29 ZBTB9 ZSCAN1	10 interactors: ERCC3 ERCC5 GTF2B GTF2E1 GTF2F1 GTF2H3 POLR2A TBP TP53 XBP1P1
Entrez ID		2960	2968
HPRD ID		01799	03456
Ensembl ID		ENSG00000153767	ENSG00000213780
Uniprot IDs		P29083	Q92759
PDB IDs		1VD4 2JTX 2RNQ 2RNR
Enriched GO Terms of Interacting Partners?		Transcription Elongation From RNA Polymerase II Promoter DNA-templated Transcription, Elongation Transcription Initiation From RNA Polymerase II Promoter Viral Process DNA-templated Transcription, Initiation Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Gene Expression Positive Regulation Of Viral Process Positive Regulation Of Viral Transcription Regulation Of Viral Process Positive Regulation Of Gene Expression Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Regulation Of Metabolic Process Regulation Of Viral Transcription Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process 7-methylguanosine MRNA Capping Positive Regulation Of Cellular Biosynthetic Process 7-methylguanosine RNA Capping Biosynthetic Process Transcription-coupled Nucleotide-excision Repair Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Positive Regulation Of Cellular Metabolic Process Transcription From RNA Polymerase I Promoter Nucleotide-excision Repair Positive Regulation Of Metabolic Process Regulation Of Cellular Process Nucleotide-excision Repair, DNA Damage Removal Positive Regulation Of Transcription, DNA-templated MRNA Processing DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter	Transcription Elongation From RNA Polymerase II Promoter DNA-templated Transcription, Elongation Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Viral Process Transcription From RNA Polymerase II Promoter Nucleotide-excision Repair 7-methylguanosine MRNA Capping 7-methylguanosine RNA Capping Transcription-coupled Nucleotide-excision Repair Positive Regulation Of Viral Transcription Regulation Of Viral Transcription Positive Regulation Of Viral Process Nucleotide-excision Repair, DNA Damage Removal Transcription, DNA-templated RNA Biosynthetic Process Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Transcription From RNA Polymerase I Promoter Regulation Of Viral Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process RNA Metabolic Process DNA Repair Gene Expression Nitrogen Compound Metabolic Process Nucleotide-excision Repair, DNA Incision Cellular Macromolecule Biosynthetic Process DNA-templated Transcription, Termination Negative Regulation Of Gene Expression, Epigenetic Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Cellular Response To DNA Damage Stimulus Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process MRNA Processing UV Protection Response To UV DNA Catabolic Process DNA Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process
Tagcloud ?		avenues bioinformatics bl canonical conferring dhx8 disrupted dnaja1 galactosidase hap1 insertional kalrn lytic mechanistic mutagenesis participate queried replication screens share tat throughput tzm uba3 ube2e3 utilizing viable vmp1
Tagcloud (Difference) ?		avenues bioinformatics bl canonical conferring dhx8 disrupted dnaja1 galactosidase hap1 insertional kalrn lytic mechanistic mutagenesis participate queried replication screens share tat throughput tzm uba3 ube2e3 utilizing viable vmp1
Tagcloud (Intersection) ?