RSPH1 and MBD4

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		RSPH1	MBD4
Description		radial spoke head component 1	methyl-CpG binding domain 4, DNA glycosylase
Image
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Outer Dense Fiber Radial Spoke Radial Spoke Head Nucleus Chromosome Cytoplasm Cytosol Cytoskeleton Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection Meiotic Spindle 9+2 Motile Cilium Radial Spoke Head 1 Radial Spoke Head 3	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Protein Binding	DNA Binding Satellite DNA Binding Catalytic Activity DNA Endonuclease Activity Protein Binding Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity Hydrolase Activity DNA N-glycosylase Activity
	Biological Process	Microtubule-based Process Spermatid Development Axoneme Assembly Meiotic Cell Cycle	DNA Repair DNA Damage Response Response To Estradiol Depyrimidination
Pathways			Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1
Drugs
Diseases
GWAS			Diisocyanate-induced asthma ( 25918132) Systemic sclerosis (anti-topoisomerase-positive) ( 29293537) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		125 interacting genes: ABCA2 AGTPBP1 APPL1 ASCL1 B4GALT3 BTBD1 BTG3 CADM1 CASK CCN2 CFH CLSTN3 CLU CMAS CNPPD1 COG4 CORO1C CORO2A CORO2B CREBZF CRMP1 CTSL CTTN CXXC5 DCTN6 DEF8 DNAJC7 DNER DOCK3 DST EDIL3 EEF2 EIF3D EZR FAIM FLOT1 FN1 FRMD4B GAMT GLS GLUL HIVEP2 JPH1 JPH3 KDM4A KDM6A KIF1A KIF1B LGI3 LONRF1 MAPK8IP1 MAPK8IP2 MBD4 MEG3 MFGE8 MIA2 MKRN3 MORN2 MORN3 MTMR2 MYCBP2 NCAM2 NELL1 NETO1 NF2 NFKBID NHP2 NPRL2 NRCAM OAT OBSL1 OSBPL1A PARP1 PAX6 PDE4DIP PLEC PNMA2 POGZ POLR2C PTPRD RARB RELN RHOG RNF10 SDHA SEPTIN3 SEZ6L SF1 SF3B1 SH3GLB2 SMARCE1 SNRNP70 SOX10 SRXN1 TF TOLLIP TRIM33 TRIM52 TUBA1B TUBB TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B UAP1L1 UBA7 UBC USP11 USP7 USP9X USP9Y WBP11 WDR13 WDR17 ZBTB38 ZBTB44 ZBTB5 ZNF197 ZNF251 ZNF34 ZNF512B ZNF662 ZNF785 ZNF793	18 interacting genes: APP CDCA2 CSNK2B DNMT3B FADD FAS HDAC1 KDM1A MLH1 NAT2 RSPH1 SIN3A SUV39H1 TRIM27 TRIM55 TRIM63 UBE2I UHRF1
Entrez ID		89765	8930
HPRD ID		11651	04654
Ensembl ID		ENSG00000160188	ENSG00000129071
Uniprot IDs		Q8WYR4	O95243
PDB IDs		8J07	2MOE 3IHO 4DK9 4E9E 4E9F 4E9G 4E9H 4EA4 4EA5 4LG7 4OFA 4OFE 4OFH 5CHZ 6VJW 7KZ0 7KZ1 7KZG
Enriched GO Terms of Interacting Partners?		Microtubule Cytoskeleton Structural Constituent Of Cytoskeleton Co-SMAD Binding Cytoskeleton Cell Periphery Neuron Migration Cell-substrate Junction Organization Cell-substrate Junction Assembly Retrograde Axonal Transport Negative Regulation Of Schwann Cell Proliferation Microtubule Cytoskeleton Organization Nucleus Positive Regulation Of Early Endosome To Late Endosome Transport Axon Intercellular Bridge Microtubule-based Process Mitotic Cell Cycle Regulation Of Nervous System Development Axon Cytoplasm Axonal Transport GTPase Activity Regulation Of Cell Projection Organization Cell Junction Organization Microtubule Regulation Of Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Organization Oligodendrocyte Cell Fate Specification Anterograde Axonal Transport Chromaffin Granule Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Glial Cell Proliferation Regulation Of Nervous System Process Regulation Of Myelination GTP Binding Axo-dendritic Transport Regulation Of Synapse Organization Cerebral Cortex Development Regulation Of Cell Morphogenesis Synapse Modulation Of Excitatory Postsynaptic Potential Retrograde Neuronal Dense Core Vesicle Transport Mitotic Spindle Positive Regulation Of Cell Differentiation Regulation Of Postsynapse Organization Cell Motility Dendrite Cytoskeleton-dependent Intracellular Transport Regulation Of Cellular Component Organization Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Hemidesmosome Assembly	Epigenetic Regulation Of Gene Expression Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Chromatin Binding Negative Regulation Of Gene Expression, Epigenetic Chromatin Remodeling Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process Chromatin Organization Negative Regulation Of Macromolecule Metabolic Process CD95 Death-inducing Signaling Complex Heterochromatin Formation Death-inducing Signaling Complex Protein Modification Process Heterochromatin Condensed Nuclear Chromosome Transferase Activity Negative Regulation Of Macromolecule Biosynthetic Process Necroptotic Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Enzyme Binding Chromosome Transcription Corepressor Activity Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction Motor Neuron Apoptotic Process Negative Regulation Of Gene Expression Cellular Response To Catecholamine Stimulus Response To Catecholamine SUMO Transferase Activity Positive Regulation Of Multicellular Organismal Process PML Body Nucleus Sin3-type Complex Macromolecule Metabolic Process Synaptonemal Complex Identical Protein Binding Negative Regulation Of Stem Cell Population Maintenance Regulation Of Primary Metabolic Process Positive Regulation Of Developmental Process Protein Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Cell Migration Neuron Maturation Immune System Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?