RSPH1 and DOCK3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		RSPH1	DOCK3
Description		radial spoke head component 1	dedicator of cytokinesis 3
Image			No pdb structure
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Outer Dense Fiber Radial Spoke Radial Spoke Head Nucleus Chromosome Cytoplasm Cytosol Cytoskeleton Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection Meiotic Spindle 9+2 Motile Cilium Radial Spoke Head 1 Radial Spoke Head 3	Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding Small GTPase Binding
	Biological Process	Microtubule-based Process Spermatid Development Axoneme Assembly Meiotic Cell Cycle	Small GTPase-mediated Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction
Pathways			RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle NTRK2 activates RAC1 NTRK2 activates RAC1 Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Age at first birth ( 34211149) Asthma ( 32296059) Bacteremia ( 27236921) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat mass ( 28552196) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Caffeine consumption from coffee or tea ( 33287642) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Cocaine dependence ( 31212010) Colorectal cancer ( 29228715) Cortical surface area (MOSTest) ( 32665545) Depressive symptom (appetite changes) (binary trait) ( 31530331) Depressive symptoms (binary sum-score) ( 31530331) Depressive symptoms (sum-score) ( 31530331) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252 32888494) Estimated glomerular filtration rate ( 31152163) Height ( 20881960 25282103) Hip circumference adjusted for BMI ( 34021172) Melanoma ( 24980573) Morning person ( 30696823) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) Trunk fat mass ( 28552196) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		125 interacting genes: ABCA2 AGTPBP1 APPL1 ASCL1 B4GALT3 BTBD1 BTG3 CADM1 CASK CCN2 CFH CLSTN3 CLU CMAS CNPPD1 COG4 CORO1C CORO2A CORO2B CREBZF CRMP1 CTSL CTTN CXXC5 DCTN6 DEF8 DNAJC7 DNER DOCK3 DST EDIL3 EEF2 EIF3D EZR FAIM FLOT1 FN1 FRMD4B GAMT GLS GLUL HIVEP2 JPH1 JPH3 KDM4A KDM6A KIF1A KIF1B LGI3 LONRF1 MAPK8IP1 MAPK8IP2 MBD4 MEG3 MFGE8 MIA2 MKRN3 MORN2 MORN3 MTMR2 MYCBP2 NCAM2 NELL1 NETO1 NF2 NFKBID NHP2 NPRL2 NRCAM OAT OBSL1 OSBPL1A PARP1 PAX6 PDE4DIP PLEC PNMA2 POGZ POLR2C PTPRD RARB RELN RHOG RNF10 SDHA SEPTIN3 SEZ6L SF1 SF3B1 SH3GLB2 SMARCE1 SNRNP70 SOX10 SRXN1 TF TOLLIP TRIM33 TRIM52 TUBA1B TUBB TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B UAP1L1 UBA7 UBC USP11 USP7 USP9X USP9Y WBP11 WDR13 WDR17 ZBTB38 ZBTB44 ZBTB5 ZNF197 ZNF251 ZNF34 ZNF512B ZNF662 ZNF785 ZNF793	11 interacting genes: CALM1 CRK HOXA1 KHDRBS1 NR3C1 PLEKHF2 PSEN1 PSEN2 RAC1 RSPH1 SRPK2
Entrez ID		89765	1795
HPRD ID		11651	10341
Ensembl ID		ENSG00000160188	ENSG00000088538
Uniprot IDs		Q8WYR4	Q8IZD9
PDB IDs		8J07
Enriched GO Terms of Interacting Partners?		Microtubule Cytoskeleton Structural Constituent Of Cytoskeleton Co-SMAD Binding Cytoskeleton Cell Periphery Neuron Migration Cell-substrate Junction Organization Cell-substrate Junction Assembly Retrograde Axonal Transport Negative Regulation Of Schwann Cell Proliferation Microtubule Cytoskeleton Organization Nucleus Positive Regulation Of Early Endosome To Late Endosome Transport Axon Intercellular Bridge Microtubule-based Process Mitotic Cell Cycle Regulation Of Nervous System Development Axon Cytoplasm Axonal Transport GTPase Activity Regulation Of Cell Projection Organization Cell Junction Organization Microtubule Regulation Of Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Organization Oligodendrocyte Cell Fate Specification Anterograde Axonal Transport Chromaffin Granule Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Glial Cell Proliferation Regulation Of Nervous System Process Regulation Of Myelination GTP Binding Axo-dendritic Transport Regulation Of Synapse Organization Cerebral Cortex Development Regulation Of Cell Morphogenesis Synapse Modulation Of Excitatory Postsynaptic Potential Retrograde Neuronal Dense Core Vesicle Transport Mitotic Spindle Positive Regulation Of Cell Differentiation Regulation Of Postsynapse Organization Cell Motility Dendrite Cytoskeleton-dependent Intracellular Transport Regulation Of Cellular Component Organization Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Hemidesmosome Assembly	Mitochondrion-endoplasmic Reticulum Membrane Tethering Protein-containing Complex Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Gamma-secretase Complex Notch Receptor Processing Aspartic Endopeptidase Activity, Intramembrane Cleaving Amyloid-beta Formation Positive Regulation Of Receptor Clustering Regulation Of Receptor Clustering Amyloid Precursor Protein Catabolic Process Neuron Migration Presynaptic Membrane Membrane Protein Ectodomain Proteolysis Amyloid-beta Metabolic Process Amyloid Precursor Protein Metabolic Process Cochlea Morphogenesis Neuron Development Cerebral Cortex Cell Migration Membrane Protein Proteolysis Regulation Of Synaptic Plasticity Regulation Of Cellular Localization Early Endosome Membrane Positive Regulation Of Dendritic Spine Development SH2 Domain Binding Protein Tyrosine Kinase Binding Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Intracellular Signal Transduction Dendrite Development Central Nervous System Neuron Development Telencephalon Cell Migration Forebrain Cell Migration G2/M Transition Of Mitotic Cell Cycle Developmental Process Regulation Of Neuron Apoptotic Process Regulation Of Dendritic Spine Development Cell Cycle G2/M Phase Transition Cell Surface Receptor Signaling Pathway Centrosome Regulation Of Substrate Adhesion-dependent Cell Spreading Cellular Response To Transforming Growth Factor Beta Stimulus Nuclear Glucocorticoid Receptor Activity Semicircular Canal Formation Negative Regulation Of Core Promoter Binding Positive Regulation Of Nucleocytoplasmic Transport Grb2-Sos Complex Synaptic Membrane Tube Morphogenesis Regulation Of Receptor Signaling Pathway Via JAK-STAT Signal Transduction
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