RSPH1 and MEG3

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		RSPH1	MEG3
Description		radial spoke head component 1	maternally expressed 3
Image			No pdb structure
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Outer Dense Fiber Radial Spoke Radial Spoke Head Nucleus Chromosome Cytoplasm Cytosol Cytoskeleton Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection Meiotic Spindle 9+2 Motile Cilium Radial Spoke Head 1 Radial Spoke Head 3	RISC Complex
	Molecular Function	Protein Binding	DsDNA-RNA Triple Helix-forming Chromatin Adaptor Activity
	Biological Process	Microtubule-based Process Spermatid Development Axoneme Assembly Meiotic Cell Cycle	Chromatin Organization Negative Regulation Of Cell Growth MiRNA-mediated Post-transcriptional Gene Silencing
Pathways
Drugs
Diseases
GWAS			Optic nerve measurement (disc area) ( 20395239) Type 1 diabetes ( 19966805) Type 2 diabetes ( 32499647)
Interacting Genes		125 interacting genes: ABCA2 AGTPBP1 APPL1 ASCL1 B4GALT3 BTBD1 BTG3 CADM1 CASK CCN2 CFH CLSTN3 CLU CMAS CNPPD1 COG4 CORO1C CORO2A CORO2B CREBZF CRMP1 CTSL CTTN CXXC5 DCTN6 DEF8 DNAJC7 DNER DOCK3 DST EDIL3 EEF2 EIF3D EZR FAIM FLOT1 FN1 FRMD4B GAMT GLS GLUL HIVEP2 JPH1 JPH3 KDM4A KDM6A KIF1A KIF1B LGI3 LONRF1 MAPK8IP1 MAPK8IP2 MBD4 MEG3 MFGE8 MIA2 MKRN3 MORN2 MORN3 MTMR2 MYCBP2 NCAM2 NELL1 NETO1 NF2 NFKBID NHP2 NPRL2 NRCAM OAT OBSL1 OSBPL1A PARP1 PAX6 PDE4DIP PLEC PNMA2 POGZ POLR2C PTPRD RARB RELN RHOG RNF10 SDHA SEPTIN3 SEZ6L SF1 SF3B1 SH3GLB2 SMARCE1 SNRNP70 SOX10 SRXN1 TF TOLLIP TRIM33 TRIM52 TUBA1B TUBB TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B UAP1L1 UBA7 UBC USP11 USP7 USP9X USP9Y WBP11 WDR13 WDR17 ZBTB38 ZBTB44 ZBTB5 ZNF197 ZNF251 ZNF34 ZNF512B ZNF662 ZNF785 ZNF793	4 interacting genes: CTNNB1 GSK3B RSPH1 STAT3
Entrez ID		89765	55384
HPRD ID		11651
Ensembl ID		ENSG00000160188	ENSG00000214548
Uniprot IDs		Q8WYR4
PDB IDs		8J07
Enriched GO Terms of Interacting Partners?		Microtubule Cytoskeleton Structural Constituent Of Cytoskeleton Co-SMAD Binding Cytoskeleton Cell Periphery Neuron Migration Cell-substrate Junction Organization Cell-substrate Junction Assembly Retrograde Axonal Transport Negative Regulation Of Schwann Cell Proliferation Microtubule Cytoskeleton Organization Nucleus Positive Regulation Of Early Endosome To Late Endosome Transport Axon Intercellular Bridge Microtubule-based Process Mitotic Cell Cycle Regulation Of Nervous System Development Axon Cytoplasm Axonal Transport GTPase Activity Regulation Of Cell Projection Organization Cell Junction Organization Microtubule Regulation Of Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Organization Oligodendrocyte Cell Fate Specification Anterograde Axonal Transport Chromaffin Granule Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Glial Cell Proliferation Regulation Of Nervous System Process Regulation Of Myelination GTP Binding Axo-dendritic Transport Regulation Of Synapse Organization Cerebral Cortex Development Regulation Of Cell Morphogenesis Synapse Modulation Of Excitatory Postsynaptic Potential Retrograde Neuronal Dense Core Vesicle Transport Mitotic Spindle Positive Regulation Of Cell Differentiation Regulation Of Postsynapse Organization Cell Motility Dendrite Cytoskeleton-dependent Intracellular Transport Regulation Of Cellular Component Organization Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Hemidesmosome Assembly	Beta-catenin Destruction Complex Wnt Signalosome RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Stem Cell Differentiation Mesenchymal Stem Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Determination Of Dorsal Identity Regulation Of Osteoblast Differentiation Negative Regulation Of Mitotic Cell Cycle, Embryonic Regulation Of Cell Development Beta-catenin-ICAT Complex Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Positive Regulation Of Neuron Apoptotic Process Enzyme-linked Receptor Protein Signaling Pathway Glial Cell Fate Determination Canonical Wnt Signaling Pathway Intracellular Signaling Cassette Negative Regulation Of Intracellular Signal Transduction Nervous System Development Maintenance Of Cell Number Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Response To Estradiol Schaffer Collateral - CA1 Synapse Protein Kinase Binding Renal Outer Medulla Development Regulation Of Anatomical Structure Morphogenesis Renal Vesicle Formation Negative Regulation Of Cell Differentiation Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Epithelial To Mesenchymal Transition Regulation Of Epithelial To Mesenchymal Transition RNA Polymerase II Transcription Regulator Complex Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development Glial Cell Differentiation Protein Phosphatase Binding Stem Cell Population Maintenance Response To Lipid Mesenchymal Cell Differentiation Glutamatergic Synapse Superior Temporal Gyrus Development Regulation Of Membrane Permeability Negative Regulation Of Type B Pancreatic Cell Development Regulation Of Stem Cell Differentiation Mitochondrial Membrane Organization Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Microtubule Anchoring At Centrosome
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