RSPH1 and UBA7

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		RSPH1	UBA7
Description		radial spoke head component 1	ubiquitin like modifier activating enzyme 7
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GO Annotations	Cellular Component	Condensed Nuclear Chromosome Outer Dense Fiber Radial Spoke Radial Spoke Head Nucleus Chromosome Cytoplasm Cytosol Cytoskeleton Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection Meiotic Spindle 9+2 Motile Cilium Radial Spoke Head 1 Radial Spoke Head 3	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin-like Modifier Activating Enzyme Activity Ligase Activity ISG15 Activating Enzyme Activity
	Biological Process	Microtubule-based Process Spermatid Development Axoneme Assembly Meiotic Cell Cycle	DNA Damage Response Protein Ubiquitination Modification-dependent Protein Catabolic Process ISG15-protein Conjugation Innate Immune Response
Pathways			ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Termination of translesion DNA synthesis Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation Modulation of host responses by IFN-stimulated genes
Drugs
Diseases
GWAS			Body mass index ( 26426971) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Extremely high intelligence ( 29520040) Menarche (age at onset) ( 25231870) Refractive error ( 32231278) Regular attendance at a gym or sports club ( 29970889) Regular attendance at a religious group ( 29970889) Sleep duration (short sleep) ( 30846698) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 21297633) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		125 interacting genes: ABCA2 AGTPBP1 APPL1 ASCL1 B4GALT3 BTBD1 BTG3 CADM1 CASK CCN2 CFH CLSTN3 CLU CMAS CNPPD1 COG4 CORO1C CORO2A CORO2B CREBZF CRMP1 CTSL CTTN CXXC5 DCTN6 DEF8 DNAJC7 DNER DOCK3 DST EDIL3 EEF2 EIF3D EZR FAIM FLOT1 FN1 FRMD4B GAMT GLS GLUL HIVEP2 JPH1 JPH3 KDM4A KDM6A KIF1A KIF1B LGI3 LONRF1 MAPK8IP1 MAPK8IP2 MBD4 MEG3 MFGE8 MIA2 MKRN3 MORN2 MORN3 MTMR2 MYCBP2 NCAM2 NELL1 NETO1 NF2 NFKBID NHP2 NPRL2 NRCAM OAT OBSL1 OSBPL1A PARP1 PAX6 PDE4DIP PLEC PNMA2 POGZ POLR2C PTPRD RARB RELN RHOG RNF10 SDHA SEPTIN3 SEZ6L SF1 SF3B1 SH3GLB2 SMARCE1 SNRNP70 SOX10 SRXN1 TF TOLLIP TRIM33 TRIM52 TUBA1B TUBB TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B UAP1L1 UBA7 UBC USP11 USP7 USP9X USP9Y WBP11 WDR13 WDR17 ZBTB38 ZBTB44 ZBTB5 ZNF197 ZNF251 ZNF34 ZNF512B ZNF662 ZNF785 ZNF793	7 interacting genes: FAS ISG15 LCOR RSPH1 UBE2E1 UBE2L3 UBE2L6
Entrez ID		89765	7318
HPRD ID		11651	01873
Ensembl ID		ENSG00000160188	ENSG00000182179
Uniprot IDs		Q8WYR4	P41226
PDB IDs		8J07	8OIF 8SE9 8SEA 8SEB 8SV8 8WWX
Enriched GO Terms of Interacting Partners?		Microtubule Cytoskeleton Structural Constituent Of Cytoskeleton Co-SMAD Binding Cytoskeleton Cell Periphery Neuron Migration Cell-substrate Junction Organization Cell-substrate Junction Assembly Retrograde Axonal Transport Negative Regulation Of Schwann Cell Proliferation Microtubule Cytoskeleton Organization Nucleus Positive Regulation Of Early Endosome To Late Endosome Transport Axon Intercellular Bridge Microtubule-based Process Mitotic Cell Cycle Regulation Of Nervous System Development Axon Cytoplasm Axonal Transport GTPase Activity Regulation Of Cell Projection Organization Cell Junction Organization Microtubule Regulation Of Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Organization Oligodendrocyte Cell Fate Specification Anterograde Axonal Transport Chromaffin Granule Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Glial Cell Proliferation Regulation Of Nervous System Process Regulation Of Myelination GTP Binding Axo-dendritic Transport Regulation Of Synapse Organization Cerebral Cortex Development Regulation Of Cell Morphogenesis Synapse Modulation Of Excitatory Postsynaptic Potential Retrograde Neuronal Dense Core Vesicle Transport Mitotic Spindle Positive Regulation Of Cell Differentiation Regulation Of Postsynapse Organization Cell Motility Dendrite Cytoskeleton-dependent Intracellular Transport Regulation Of Cellular Component Organization Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Hemidesmosome Assembly	ISG15-protein Conjugation Ubiquitin Conjugating Enzyme Activity ISG15 Transferase Activity Ubiquitin-like Protein Transferase Activity Modification-dependent Protein Catabolic Process Protein Ubiquitination Ubiquitin-protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Protein Polyubiquitination Post-translational Protein Modification Macromolecule Catabolic Process Fas Signaling Pathway Ubiquitin Ligase Complex Proteolysis Radial Spoke Head 1 Radial Spoke Head 3 Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Oligomerization Cellular Response To Hyperoxia Radial Spoke Head CD95 Death-inducing Signaling Complex Death-inducing Signaling Complex Activation-induced Cell Death Of T Cells Outer Dense Fiber Regulation Of Protein Ubiquitination Necroptotic Signaling Pathway Protein Modification Process Ubiquitin-protein Transferase Activator Activity
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