RSPH1 and GLS

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		RSPH1	GLS
Description		radial spoke head component 1	glutaminase
Image
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Outer Dense Fiber Radial Spoke Radial Spoke Head Nucleus Chromosome Cytoplasm Cytosol Cytoskeleton Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection Meiotic Spindle 9+2 Motile Cilium Radial Spoke Head 1 Radial Spoke Head 3	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Synapse
	Molecular Function	Protein Binding	Glutaminase Activity Protein Binding Hydrolase Activity
	Biological Process	Microtubule-based Process Spermatid Development Axoneme Assembly Meiotic Cell Cycle	Suckling Behavior Regulation Of Respiratory Gaseous Exchange By Nervous System Process Amino Acid Metabolic Process Glutamate Biosynthetic Process Glutamine Metabolic Process L-glutamine Catabolic Process Chemical Synaptic Transmission Protein Homotetramerization Intracellular Glutamate Homeostasis
Pathways			Glutamate Neurotransmitter Release Cycle TP53 Regulates Metabolic Genes Glutamate and glutamine metabolism
Drugs			Glutamic acid
Diseases
GWAS			Appendicular lean mass ( 33097823) Chronotype ( 30696823) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 27863252 32888494) JT interval (sulfonylurea treatment interaction) ( 27958378) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		125 interacting genes: ABCA2 AGTPBP1 APPL1 ASCL1 B4GALT3 BTBD1 BTG3 CADM1 CASK CCN2 CFH CLSTN3 CLU CMAS CNPPD1 COG4 CORO1C CORO2A CORO2B CREBZF CRMP1 CTSL CTTN CXXC5 DCTN6 DEF8 DNAJC7 DNER DOCK3 DST EDIL3 EEF2 EIF3D EZR FAIM FLOT1 FN1 FRMD4B GAMT GLS GLUL HIVEP2 JPH1 JPH3 KDM4A KDM6A KIF1A KIF1B LGI3 LONRF1 MAPK8IP1 MAPK8IP2 MBD4 MEG3 MFGE8 MIA2 MKRN3 MORN2 MORN3 MTMR2 MYCBP2 NCAM2 NELL1 NETO1 NF2 NFKBID NHP2 NPRL2 NRCAM OAT OBSL1 OSBPL1A PARP1 PAX6 PDE4DIP PLEC PNMA2 POGZ POLR2C PTPRD RARB RELN RHOG RNF10 SDHA SEPTIN3 SEZ6L SF1 SF3B1 SH3GLB2 SMARCE1 SNRNP70 SOX10 SRXN1 TF TOLLIP TRIM33 TRIM52 TUBA1B TUBB TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B UAP1L1 UBA7 UBC USP11 USP7 USP9X USP9Y WBP11 WDR13 WDR17 ZBTB38 ZBTB44 ZBTB5 ZNF197 ZNF251 ZNF34 ZNF512B ZNF662 ZNF785 ZNF793	7 interacting genes: ATXN10 CDC42 OGT PARD6A RSPH1 SNTA1 TAX1BP3
Entrez ID		89765	2744
HPRD ID		11651	00700
Ensembl ID		ENSG00000160188	ENSG00000115419
Uniprot IDs		Q8WYR4	H7C201 O94925
PDB IDs		8J07	3CZD 3UNW 3UO9 3VOY 3VOZ 3VP0 3VP1 3VP2 3VP3 3VP4 4O7D 5D3O 5FI2 5FI6 5FI7 5HL1 5I94 5JYO 5JYP 5U0I 5U0J 5UQE 5WJ6 6LOX 6UJG 6UJM 6UK6 6UKB 6UL9 6ULA 6ULJ 6UMC 6UMD 6UME 6UMF 7REN 7RGG 7SBM 7SBN 8BSK 8BSL 8BSM 8BSN 8GWR 8IMA 8IMB 8JUB 8JUE 8SZJ
Enriched GO Terms of Interacting Partners?		Microtubule Cytoskeleton Structural Constituent Of Cytoskeleton Co-SMAD Binding Cytoskeleton Cell Periphery Neuron Migration Cell-substrate Junction Organization Cell-substrate Junction Assembly Retrograde Axonal Transport Negative Regulation Of Schwann Cell Proliferation Microtubule Cytoskeleton Organization Nucleus Positive Regulation Of Early Endosome To Late Endosome Transport Axon Intercellular Bridge Microtubule-based Process Mitotic Cell Cycle Regulation Of Nervous System Development Axon Cytoplasm Axonal Transport GTPase Activity Regulation Of Cell Projection Organization Cell Junction Organization Microtubule Regulation Of Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Organization Oligodendrocyte Cell Fate Specification Anterograde Axonal Transport Chromaffin Granule Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Glial Cell Proliferation Regulation Of Nervous System Process Regulation Of Myelination GTP Binding Axo-dendritic Transport Regulation Of Synapse Organization Cerebral Cortex Development Regulation Of Cell Morphogenesis Synapse Modulation Of Excitatory Postsynaptic Potential Retrograde Neuronal Dense Core Vesicle Transport Mitotic Spindle Positive Regulation Of Cell Differentiation Regulation Of Postsynapse Organization Cell Motility Dendrite Cytoskeleton-dependent Intracellular Transport Regulation Of Cellular Component Organization Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Hemidesmosome Assembly	Cell Projection Cytoskeleton GTP-dependent Protein Binding Wnt Signaling Pathway Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Projection Assembly Plasma Membrane Bounded Cell Projection Assembly Plasma Membrane Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Cytokinesis Cytoplasm GBD Domain Binding Storage Vacuole Endothelin Receptor Signaling Pathway Involved In Heart Process Protein O-acetylglucosaminyltransferase Activity Protein Transport From Ciliary Membrane To Plasma Membrane Axoneme Radial Spoke Head 1 Radial Spoke Head 3 Cell-cell Junction Organization Organelle Organization Positive Regulation Of Pinocytosis Apolipoprotein A-I Receptor Binding G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Cell Division Midbody Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Neuropilin Signaling Pathway Negative Regulation Of Protein-containing Complex Assembly Cellular Component Assembly Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Establishment Or Maintenance Of Cell Polarity Cytosol Syntrophin Complex Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Cilium Positive Regulation Of Protein Localization To Centrosome PAR Polarity Complex Outer Dense Fiber Radial Spoke Head Organelle Assembly Establishment Of Golgi Localization Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Protein-containing Complex
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