RSPH1 and DEF8

Number of citations: 83 (PubMedID 35914814)
Data Source: BioGRID (two hybrid)

		RSPH1	DEF8
Name		radial spoke head component 1	differentially expressed in FDCP 8 homolog
Structure			No pdb structure
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Outer Dense Fiber Radial Spoke Radial Spoke Head Nucleus Chromosome Cytoplasm Cytosol Cytoskeleton Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection Meiotic Spindle 9+2 Motile Cilium Radial Spoke Head 1 Radial Spoke Head 3	None
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Microtubule-based Process Spermatid Development Axoneme Assembly Meiotic Cell Cycle	Lysosome Localization Positive Regulation Of Bone Resorption Positive Regulation Of Ruffle Assembly
GWAS		No GWAS studies recorded	Aging traits (healthspan, parental lifespan or longevity) (multivariate analysis) ( 32678081 ) Basal cell carcinoma ( 33549134 ) Brain morphology (MOSTest) ( 32665545 ) Brown vs. black hair color ( 30531825 ) Hip circumference adjusted for BMI ( 34021172 ) Keratinocyte cancer (MTAG) ( 31174203 ) Low tan response ( 29739929 ) Red vs. brown/black hair color ( 30531825 ) Squamous cell carcinoma ( 26829030 26908436 )
Interacting Genes		125 interacting genes: ABCA2 AGTPBP1 APPL1 ASCL1 B4GALT3 BTBD1 BTG3 CADM1 CASK CCN2 CFH CLSTN3 CLU CMAS CNPPD1 COG4 CORO1C CORO2A CORO2B CREBZF CRMP1 CTSL CTTN CXXC5 DCTN6 DEF8 DNAJC7 DNER DOCK3 DST EDIL3 EEF2 EIF3D EZR FAIM FLOT1 FN1 FRMD4B GAMT GLS GLUL HIVEP2 JPH1 JPH3 KDM4A KDM6A KIF1A KIF1B LGI3 LONRF1 MAPK8IP1 MAPK8IP2 MBD4 MEG3 MFGE8 MIA2 MKRN3 MORN2 MORN3 MTMR2 MYCBP2 NCAM2 NELL1 NETO1 NF2 NFKBID NHP2 NPRL2 NRCAM OAT OBSL1 OSBPL1A PARP1 PAX6 PDE4DIP PLEC PNMA2 POGZ POLR2C PTPRD RARB RELN RHOG RNF10 SDHA SEPTIN3 SEZ6L SF1 SF3B1 SH3GLB2 SMARCE1 SNRNP70 SOX10 SRXN1 TF TOLLIP TRIM33 TRIM52 TUBA1B TUBB TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B UAP1L1 UBA7 UBC USP11 USP7 USP9X USP9Y WBP11 WDR13 WDR17 ZBTB38 ZBTB44 ZBTB5 ZNF197 ZNF251 ZNF34 ZNF512B ZNF662 ZNF785 ZNF793	7 interacting genes: CFTR MEOX2 RSPH1 TRIM55 TRIM63 ZNF417 ZNF587
Entrez ID		89765	54849
HPRD ID		11651	07882
Ensembl ID		ENSG00000160188	ENSG00000140995
Uniprot IDs		Q8WYR4	Q6ZN54
PDB IDs		8J07	Not available
GO Terms Enriched among Interactors		Microtubule Cytoskeleton Structural Constituent Of Cytoskeleton Co-SMAD Binding Cytoskeleton Cell Periphery Neuron Migration Cell-substrate Junction Organization Cell-substrate Junction Assembly Retrograde Axonal Transport Negative Regulation Of Schwann Cell Proliferation Microtubule Cytoskeleton Organization Nucleus Positive Regulation Of Early Endosome To Late Endosome Transport Axon Intercellular Bridge Microtubule-based Process Mitotic Cell Cycle Regulation Of Nervous System Development Axon Cytoplasm Axonal Transport GTPase Activity Regulation Of Cell Projection Organization Cell Junction Organization Microtubule Regulation Of Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Organization Oligodendrocyte Cell Fate Specification Anterograde Axonal Transport Chromaffin Granule Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Glial Cell Proliferation Regulation Of Nervous System Process Regulation Of Myelination GTP Binding Axo-dendritic Transport Regulation Of Synapse Organization Cerebral Cortex Development Regulation Of Cell Morphogenesis Synapse Modulation Of Excitatory Postsynaptic Potential Retrograde Neuronal Dense Core Vesicle Transport Mitotic Spindle Positive Regulation Of Cell Differentiation Regulation Of Postsynapse Organization Cell Motility Dendrite Cytoskeleton-dependent Intracellular Transport Regulation Of Cellular Component Organization Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Hemidesmosome Assembly	Nucleus Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Radial Spoke Head 1 Radial Spoke Head 3 Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Somite Specification Diapedesis Skeletal Muscle Atrophy Skeletal Muscle Adaptation Striated Muscle Atrophy Outer Dense Fiber Radial Spoke Head Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis Muscle Atrophy