RSPH1 and KDM4A

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		RSPH1	KDM4A
Description		radial spoke head component 1	lysine demethylase 4A
Image
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Outer Dense Fiber Radial Spoke Radial Spoke Head Nucleus Chromosome Cytoplasm Cytosol Cytoskeleton Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection Meiotic Spindle 9+2 Motile Cilium Radial Spoke Head 1 Radial Spoke Head 3	Chromatin Fibrillar Center Nucleus Nucleoplasm Pericentric Heterochromatin Cytosol
	Molecular Function	Protein Binding	Protein Binding Zinc Ion Binding Oxidoreductase Activity Ubiquitin Protein Ligase Binding Histone Demethylase Activity Histone H3K9 Demethylase Activity Metal Ion Binding Dioxygenase Activity Histone H3K36 Demethylase Activity Histone H4K20me2 Reader Activity Histone H3K36me2/H3K36me3 Demethylase Activity Histone H3K9me2/H3K9me3 Demethylase Activity
	Biological Process	Microtubule-based Process Spermatid Development Axoneme Assembly Meiotic Cell Cycle	Chromatin Organization Chromatin Remodeling Regulation Of Gene Expression Negative Regulation Of Autophagy Negative Regulation Of Gene Expression Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of DNA-templated Transcription
Pathways			HDMs demethylate histones Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS			Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Household income (MTAG) ( 31844048) Menarche (age at onset) ( 25231870) Number of sexual partners ( 30643258) Perceived intensity of sweet substances ( 31005972) Red blood cell count ( 32888494) Refractive error ( 32231278) Schizophrenia ( 25056061 28991256 29483656) Smoking status (ever vs never smokers) ( 30643258) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		125 interacting genes: ABCA2 AGTPBP1 APPL1 ASCL1 B4GALT3 BTBD1 BTG3 CADM1 CASK CCN2 CFH CLSTN3 CLU CMAS CNPPD1 COG4 CORO1C CORO2A CORO2B CREBZF CRMP1 CTSL CTTN CXXC5 DCTN6 DEF8 DNAJC7 DNER DOCK3 DST EDIL3 EEF2 EIF3D EZR FAIM FLOT1 FN1 FRMD4B GAMT GLS GLUL HIVEP2 JPH1 JPH3 KDM4A KDM6A KIF1A KIF1B LGI3 LONRF1 MAPK8IP1 MAPK8IP2 MBD4 MEG3 MFGE8 MIA2 MKRN3 MORN2 MORN3 MTMR2 MYCBP2 NCAM2 NELL1 NETO1 NF2 NFKBID NHP2 NPRL2 NRCAM OAT OBSL1 OSBPL1A PARP1 PAX6 PDE4DIP PLEC PNMA2 POGZ POLR2C PTPRD RARB RELN RHOG RNF10 SDHA SEPTIN3 SEZ6L SF1 SF3B1 SH3GLB2 SMARCE1 SNRNP70 SOX10 SRXN1 TF TOLLIP TRIM33 TRIM52 TUBA1B TUBB TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B UAP1L1 UBA7 UBC USP11 USP7 USP9X USP9Y WBP11 WDR13 WDR17 ZBTB38 ZBTB44 ZBTB5 ZNF197 ZNF251 ZNF34 ZNF512B ZNF662 ZNF785 ZNF793	6 interacting genes: H3C1 H4C1 RB1 RNF168 RNF8 RSPH1
Entrez ID		89765	9682
HPRD ID		11651	17168
Ensembl ID		ENSG00000160188	ENSG00000066135
Uniprot IDs		Q8WYR4	O75164
PDB IDs		8J07	2GF7 2GFA 2GP3 2GP5 2OQ6 2OQ7 2OS2 2OT7 2OX0 2P5B 2PXJ 2Q8C 2Q8D 2Q8E 2QQR 2QQS 2VD7 2WWJ 2YBK 2YBP 2YBS 3NJY 3PDQ 3RVH 3U4S 4AI9 4BIS 4GD4 4URA 4V2V 4V2W 5A7N 5A7O 5A7P 5A7Q 5A7S 5A7W 5A80 5ANQ 5D6W 5D6X 5D6Y 5F2S 5F2W 5F32 5F37 5F39 5F3C 5F3E 5F3G 5F3I 5F5I 5FPV 5FWE 5FY8 5FYC 5FYH 5FYI 5LY1 5LY2 5TVR 5TVS 5VAR 5VGI 5VMP 6CG1 6CG2 6G5W 6G5X 6H4O 6H4P 6H4Q 6H4R 6H4S 6H4T 6H4U 6H4V 6H4W 6H4X 6H4Y 6H8P 6HGT 7D4A 7EQV 8WD3 9GII 9GLE 9GP1 9GP4
Enriched GO Terms of Interacting Partners?		Microtubule Cytoskeleton Structural Constituent Of Cytoskeleton Co-SMAD Binding Cytoskeleton Cell Periphery Neuron Migration Cell-substrate Junction Organization Cell-substrate Junction Assembly Retrograde Axonal Transport Negative Regulation Of Schwann Cell Proliferation Microtubule Cytoskeleton Organization Nucleus Positive Regulation Of Early Endosome To Late Endosome Transport Axon Intercellular Bridge Microtubule-based Process Mitotic Cell Cycle Regulation Of Nervous System Development Axon Cytoplasm Axonal Transport GTPase Activity Regulation Of Cell Projection Organization Cell Junction Organization Microtubule Regulation Of Plasma Membrane Bounded Cell Projection Organization Cytoskeleton Organization Oligodendrocyte Cell Fate Specification Anterograde Axonal Transport Chromaffin Granule Regulation Of Early Endosome To Late Endosome Transport Negative Regulation Of Glial Cell Proliferation Regulation Of Nervous System Process Regulation Of Myelination GTP Binding Axo-dendritic Transport Regulation Of Synapse Organization Cerebral Cortex Development Regulation Of Cell Morphogenesis Synapse Modulation Of Excitatory Postsynaptic Potential Retrograde Neuronal Dense Core Vesicle Transport Mitotic Spindle Positive Regulation Of Cell Differentiation Regulation Of Postsynapse Organization Cell Motility Dendrite Cytoskeleton-dependent Intracellular Transport Regulation Of Cellular Component Organization Commitment Of Neuronal Cell To Specific Neuron Type In Forebrain Hemidesmosome Assembly	Protein Localization To Chromosome Chromatin Remodeling Epigenetic Regulation Of Gene Expression Chromosome Organization Chromosome Isotype Switching Somatic Diversification Of Immunoglobulins Involved In Immune Response DNA Repair-dependent Chromatin Remodeling Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Negative Regulation Of DNA-templated Transcription, Elongation Negative Regulation Of Transcription Elongation By RNA Polymerase II Cytoplasmic Translational Initiation Somatic Recombination Of Immunoglobulin Gene Segments Attachment Of Spindle Microtubules To Kinetochore Chromatin Organization Protein Localization To Chromosome, Centromeric Region B Cell Activation Somatic Cell DNA Recombination Somatic Diversification Of Immunoglobulins Interstrand Cross-link Repair Translation Initiation Factor Activity Cyanocobalamin Reductase (cyanide-eliminating) (NADP+) Activity Histone H2AK15 Ubiquitin Ligase Activity Double-strand Break Repair Via Nonhomologous End Joining B Cell Activation Involved In Immune Response
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