FASTK and WIPF1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		FASTK	WIPF1
Description		Fas activated serine/threonine kinase	WAS/WASL interacting protein family member 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Ribonucleoprotein Granule	Ruffle Cytoplasm Cytosol Cytoskeleton Actin Filament Actin Cytoskeleton Cytoplasmic Vesicle Cell Projection
	Molecular Function	Nucleotide Binding RNA Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Fas-activated Serine/threonine Kinase Activity Protein Serine Kinase Activity	Actin Binding Protein Binding Profilin Binding Cytoskeletal Anchor Activity SH3 Domain Binding Protein Folding Chaperone
	Biological Process	Mitochondrial RNA Processing Protein Phosphorylation Apoptotic Process Regulation Of RNA Splicing Regulation Of Mitochondrial MRNA Stability Apoptotic Signaling Pathway	Protein Folding Actin Polymerization Or Depolymerization Actin Filament-based Process Actin Filament-based Movement Response To Other Organism Protein-containing Complex Assembly
Pathways			Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs CDC42 GTPase cycle RAC1 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Eyebrow thickness ( 26926045)	Atrial fibrillation ( 29892015 30061737) Mean platelet volume ( 32888494) Platelet distribution width ( 32888494) Pulse pressure ( 27841878) Resting heart rate ( 27798624) Systolic blood pressure ( 27841878) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		9 interacting genes: CALCOCO2 CHERP ESRRG MDFI PRPF31 RBPMS TIA1 TOP3B WIPF1	26 interacting genes: ABI2 ACTC1 ACTG1 ALAS1 APBB1 CACNG2 CDC42 CEBPA CRKL CTTN FASTK GRB2 HCK HOMER3 ITSN2 NCK1 PRKCQ PRPF40A RER1 SEC24C SH3RF1 WAS WASL WBP4 WWP2 ZAP70
Entrez ID		10922	7456
HPRD ID		07368	03835
Ensembl ID		ENSG00000164896	ENSG00000115935
Uniprot IDs		A0A090N8I0 A0A090N8Z7 Q14296	A0A140VJZ9 E9PB87 O43516 Q2YDC4
PDB IDs			2A41 9EZN 9EZO 9EZP
Enriched GO Terms of Interacting Partners?		RNA Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Binding RNA Topoisomerase Activity Ribonucleoprotein Complex Localization Cytoplasmic Stress Granule DNA Topoisomerase III-beta-TDRD3 Complex U4atac SnRNP AF-2 Domain Binding Regulation Of MRNA Processing MRNA 3'-UTR Binding Regulation Of MRNA Splicing, Via Spliceosome DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity MRNA CDS Binding SnRNP Binding U4atac SnRNA Binding Nucleic Acid Binding SnoRNA Localization	Actin Filament Regulation Of Actin Filament Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Cell Motility Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Lamellipodium Cell-cell Junction Phosphotyrosine Residue Binding Positive Regulation Of Actin Filament Polymerization Regulation Of Cytoskeleton Organization Actin Filament-based Process Actin Filament Organization Proline-rich Region Binding Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Cell Projection Morphogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Migration Cytosol Regulation Of Cell Projection Organization Positive Regulation Of Protein Polymerization Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Actin Cytoskeleton Organization Dendritic Spine Organization Cell Projection Organization Regulation Of Cell Projection Assembly Regulation Of Lamellipodium Assembly Vesicle Membrane Regulation Of Cellular Component Organization Positive Regulation Of Cellular Component Organization Intracellular Signaling Cassette Immune Response-regulating Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Neuron Projection Organization Regulation Of Cellular Component Size Regulation Of Actin Filament Polymerization Postsynapse Organization Neuron Projection Morphogenesis Regulation Of Organelle Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Small GTPase-mediated Signal Transduction Cell Junction Organization Peptidyl-tyrosine Phosphorylation Regulation Of Lamellipodium Organization Regulation Of Immune System Process Antigen Receptor-mediated Signaling Pathway
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