FASTK and TIA1

Number of citations of the paper that reports this interaction (PubMedID 7544399)
47

Data Source:
HPRD (in vitro, in vivo)

		FASTK	TIA1
Description		Fas activated serine/threonine kinase	TIA1 cytotoxic granule associated RNA binding protein
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix Ribonucleoprotein Granule	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Stress Granule Ribonucleoprotein Complex
	Molecular Function	Nucleotide Binding RNA Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Fas-activated Serine/threonine Kinase Activity Protein Serine Kinase Activity	Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Protein Binding Poly(A) Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Mitochondrial RNA Processing Protein Phosphorylation Apoptotic Process Regulation Of RNA Splicing Regulation Of Mitochondrial MRNA Stability Apoptotic Signaling Pathway	Regulation Of Alternative MRNA Splicing, Via Spliceosome Negative Regulation Of Cytokine Production MRNA Processing Apoptotic Process RNA Splicing Negative Regulation Of Translation Stress Granule Assembly Regulation Of MRNA Splicing, Via Spliceosome Protein Localization To Cytoplasmic Stress Granule Positive Regulation Of Epithelial Cell Apoptotic Process
Pathways			FGFR2 alternative splicing
Drugs
Diseases
GWAS		Eyebrow thickness ( 26926045)	Acne (severe) ( 24927181) Male-pattern baldness ( 28196072)
Interacting Genes		9 interacting genes: CALCOCO2 CHERP ESRRG MDFI PRPF31 RBPMS TIA1 TOP3B WIPF1	2 interacting genes: FASTK WBP4
Entrez ID		10922	7072
HPRD ID		07368	04626
Ensembl ID		ENSG00000164896	ENSG00000116001
Uniprot IDs		A0A090N8I0 A0A090N8Z7 Q14296	E5RGV5 F8W8I6 P31483
PDB IDs			2MJN 3BS9 5ITH 5O2V 5O3J 6ELD 7VI4 7VI5
Enriched GO Terms of Interacting Partners?		RNA Processing Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Binding RNA Topoisomerase Activity Ribonucleoprotein Complex Localization Cytoplasmic Stress Granule DNA Topoisomerase III-beta-TDRD3 Complex U4atac SnRNP AF-2 Domain Binding Regulation Of MRNA Processing MRNA 3'-UTR Binding Regulation Of MRNA Splicing, Via Spliceosome DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity MRNA CDS Binding SnRNP Binding U4atac SnRNA Binding Nucleic Acid Binding SnoRNA Localization	Fas-activated Serine/threonine Kinase Activity Mitogen-activated Protein Kinase Kinase Binding Phosphorylation Protein Serine Kinase Activity Protein Phosphorylation JUN Kinase Kinase Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Mitochondrial MRNA Stability Kinase Activity Positive Regulation Of JUN Kinase Activity MAP Kinase Kinase Kinase Activity Mitogen-activated Protein Kinase Kinase Kinase Binding Ribonucleoprotein Granule Mitochondrial RNA Processing Precatalytic Spliceosome Proline-rich Region Binding MRNA Cis Splicing, Via Spliceosome Positive Regulation Of MAP Kinase Activity
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