UBAP2 and PSMB8

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		UBAP2	PSMB8
Name		ubiquitin associated protein 2	proteasome 20S subunit beta 8
Structure		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Chromosome Cytoplasm	Proteasome Complex Nucleus Nucleoplasm Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Extracellular Exosome Spermatoproteasome Complex
	Molecular Function	RNA Binding Protein Binding Cadherin Binding	Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	Regulation Of Gene Expression Hematopoietic Stem Cell Homeostasis	Immune System Process Proteolysis Antigen Processing And Presentation Cell Differentiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Fat Cell Differentiation Proteolysis Involved In Protein Catabolic Process
Pathways		None	ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Interferon alpha/beta signaling Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation
Drugs		None	Carfilzomib
GWAS		Adult body size ( 32376654 ) Bipolar disorder ( 20351715 ) Daytime nap ( 33568662 ) Estimated glomerular filtration rate ( 31152163 ) Heel bone mineral density ( 30598549 ) High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Lymphocyte count ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Mosquito bite size ( 28199695 ) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892 ) Refractive error ( 32231278 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Serum alkaline phosphatase levels ( 33547301 ) Type 2 diabetes ( 30297969 30054458 ) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408 )	Asthma ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) IgA nephropathy ( 25305756 32912934 ) Nephropathy ( 21399633 )
Novel Interactors		2 novel interactors: GBA2 TMEM8B	1 novel interactors: NOTCH4
Interacting Genes		45 interacting genes: ASB13 ATPAF2 BANP C10orf55 CREM DAZAP2 EFHC1 FAM168B FNDC3B FOXH1 HGS IGFN1 ISX ITCH JMJD7 KANK2 KRTAP15-1 LCK MGAT5B NOXA1 NPAS2 NUTF2 OTX1 PLAC8 PLEKHB2 PPP2CA PRSS53 PSMB8 RBPMS RHOXF2 SHC3 SPAG8 SPMIP9 TENT5B TEP1 TFG TLE5 TP53BP1 TRAPPC6A UBC USP7 VENTX VPS37C WRAP53 ZNF34	22 interacting genes: ABCB1 DUSP23 GNPNAT1 INCA1 LSM1 MEOX2 NFKBID PFDN5 POLR2G POMP PSMB10 REL SNX5 TAP1 TAP2 TENT5B TRAF3 TRIP13 UBAP2 WWOX YJEFN3 ZMYND12
Entrez ID		55833	5696
HPRD ID		06748	01515
Ensembl ID		ENSG00000137073	ENSG00000204264
Uniprot IDs		A0A8C8MQ70 B4DH66 B7Z7P2 Q5T6F2 Q9P0H6	P28062
PDB IDs		Not available	5L5A 5L5B 5L5D 5L5E 5L5F 5L5H 5L5I 5L5J 5L5O 5L5P 5L5Q 5L5R 5L5S 5L5T 5L5U 5L5V 5LTT 5M2B 6AVO 6E5B 7AWE 7B12
GO Terms Enriched among Interactors		P53 Binding Axonemal A Tubule Inner Sheath Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome	Peptide Transmembrane Transporter Activity ABC-type Peptide Antigen Transporter Activity TAP Complex ABC-type Peptide Transporter Activity TAP1 Binding Cytosol To Endoplasmic Reticulum Transport ABC-type Transporter Activity MHC Class Ib Protein Binding MHC Protein Binding MHC Class I Peptide Loading Complex Peptide Antigen Assembly With MHC Class I Protein Complex P-body Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I RNA Polymerase III Assembly RNA Polymerase I Assembly Cellular Response To Nonylphenol Response To Quercetin Cellular Response To Borneol Response To Codeine Amide Transport Daunorubicin Transport Positive Regulation Of Establishment Of Sertoli Cell Barrier Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Binding Antigen Processing And Presentation Of Endogenous Antigen Tapasin Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Via ER Pathway, TAP-dependent Macropinocytic Cup Glucosamine 6-phosphate N-acetyltransferase Activity ATP Hydrolysis Activity