UBAP2 and WRAP53

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		UBAP2	WRAP53
Description		ubiquitin associated protein 2	WD repeat containing antisense to TP53
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Chromosome Cytoplasm	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Telomerase Holoenzyme Complex Cytosol Cajal Body Nuclear Body Site Of Double-strand Break
	Molecular Function	RNA Binding Protein Binding Cadherin Binding	RNA Binding Protein Binding Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Protein-containing Complex Binding Protein-folding Chaperone Binding Telomerase RNA Binding Protein Carrier Chaperone RNA Folding Chaperone
	Biological Process	Regulation Of Gene Expression Hematopoietic Stem Cell Homeostasis	DNA Repair DNA Damage Response Telomere Maintenance Via Telomerase Cajal Body Organization Telomere Formation Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase RNA Folding Positive Regulation Of DNA Repair ScaRNA Localization To Cajal Body Telomerase RNA Localization To Cajal Body Positive Regulation Of Establishment Of Protein Localization To Telomere Protein Localization To Cajal Body Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of Double-strand Break Repair Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways			Telomere Extension By Telomerase Association of TriC/CCT with target proteins during biosynthesis
Drugs
Diseases
GWAS		Adult body size ( 32376654) Bipolar disorder ( 20351715) Daytime nap ( 33568662) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte count ( 32888494) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Serum alkaline phosphatase levels ( 33547301) Type 2 diabetes ( 30297969 30054458) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)	Alcohol consumption ( 31358974) Cognitive function ( 28093568)
Interacting Genes		45 interacting genes: ASB13 ATPAF2 BANP C10orf55 CREM DAZAP2 EFHC1 FAM168B FNDC3B FOXH1 HGS IGFN1 ISX ITCH JMJD7 KANK2 KRTAP15-1 LCK MGAT5B NOXA1 NPAS2 NUTF2 OTX1 PLAC8 PLEKHB2 PPP2CA PRSS53 PSMB8 RBPMS RHOXF2 SHC3 SPAG8 SPMIP9 TENT5B TEP1 TFG TLE5 TP53BP1 TRAPPC6A UBC USP7 VENTX VPS37C WRAP53 ZNF34	4 interacting genes: DSCR9 RECQL4 UBAP2 VAC14
Entrez ID		55833	55135
HPRD ID		06748	07670
Ensembl ID		ENSG00000137073	ENSG00000141499
Uniprot IDs		A0A8C8MQ70 B4DH66 B7Z7P2 Q5T6F2 Q9P0H6	Q9BUR4
PDB IDs			7BGB 7TRC 7V9A 8OUE 8OUF
Enriched GO Terms of Interacting Partners?		P53 Binding Axonemal A Tubule Inner Sheath Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome	Telomeric D-loop Binding Catalytic Activity, Acting On DNA Four-way Junction Helicase Activity Telomeric D-loop Disassembly Bubble DNA Binding DNA/DNA Annealing Activity Oxidized Purine DNA Binding PAS Complex Presynaptic Endosome Telomeric Loop Disassembly 3'-5' DNA Helicase Activity
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