ORC5 and DMRTA1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ORC5	DMRTA1
Description		origin recognition complex subunit 5	DMRT like family A1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Chromosome Cytosol	Chromatin Nucleus
	Molecular Function	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Replication DNA Replication Initiation Regulation Of DNA Replication	Ovarian Follicle Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Sex Differentiation Male Mating Behavior
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Night sleep phenotypes ( 27126917) Sucrose liking ( 31005972)	Adventurousness ( 30643258) Asthma ( 34103634 30929738) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Atopic dermatitis ( 25865352) Blood sugar levels ( 29403010) Body mass index ( 28892062) Brain morphology (MOSTest) ( 32665545) Cataracts ( 34127677) Cataracts (operation) ( 31816047) Chronic lymphocytic leukemia ( 26956414) Dentures ( 31235808) General risk tolerance (MTAG) ( 30643258) Glucose homeostasis traits ( 25524916) Hematological and biochemical traits ( 31902109) Hemoglobin A1c levels ( 29403010) Hypertension ( 30487518) Lymphocyte count ( 29403010) Metabolite levels ( 23823483) Monocyte count ( 29403010) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Platelet count ( 29403010) Post bronchodilator FEV1/FVC ratio in smoking ( 30068317) Pulse pressure ( 27841878) Systolic blood pressure ( 30224653) Tuberculosis ( 24057671) Type 2 diabetes ( 30718926 26818947) White blood cell count ( 29403010)
Interacting Genes		31 interacting genes: CALCOCO2 CDC45 CDC5L CDC6 CDC7 CEBPA DBF4 DMRTA1 H3-4 H4C16 KRT18 LAMB2 MCM2 MCM3 MCM4 MCM5 MCM7 NIF3L1 NONO ORC1 ORC2 ORC3 ORC4 ORC6 RPA2 SIPA1L2 STAB1 TAX1BP1 TXNDC11 UBQLN4 USP2	2 interacting genes: ORC5 STAT5B
Entrez ID		5001	63951
HPRD ID		09086	10913
Ensembl ID		ENSG00000164815	ENSG00000176399
Uniprot IDs		A4D0P7 O43913 Q53FC8	Q5VZB9
PDB IDs		5UJ7 5UJM 7CTE 7CTF 7CTG 7JPO 7JPP 7JPQ 7JPR 7JPS 8RWV 8S0C 8S0D 8S0E 8S0F
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation DNA Replication DNA Replication Origin Binding DNA Metabolic Process Double-strand Break Repair Via Break-induced Replication Chromosome, Telomeric Region Nuclear Origin Of Replication Recognition Complex CMG Complex Origin Recognition Complex Regulation Of DNA Replication MCM Complex Regulation Of DNA-templated DNA Replication Initiation Nucleic Acid Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Single-stranded DNA Helicase Activity DNA Recombination Regulation Of DNA Metabolic Process DNA Repair Single-stranded DNA Binding Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Chromosome Nucleoplasm Mitotic DNA Replication Initiation DNA Damage Response Nucleus DNA Binding DNA Strand Elongation Involved In DNA Replication DNA Replication Preinitiation Complex Helicase Activity DNA Replication Checkpoint Signaling DNA Strand Elongation Macromolecule Metabolic Process Cellular Response To Stress Regulation Of Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle DNA Helicase Activity ATP Hydrolysis Activity Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Mitotic DNA Replication Checkpoint Signaling Nucleolus DNA Replication Factor A Complex 3'-5' DNA Helicase Activity Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Cell Cycle Process	Nuclear Origin Of Replication Recognition Complex Origin Recognition Complex Positive Regulation Of Gamma-delta T Cell Differentiation Taurine Metabolic Process Response To Interleukin-15 Positive Regulation Of Gamma-delta T Cell Activation Development Of Secondary Female Sexual Characteristics Nuclear Glucocorticoid Receptor Binding Regulation Of Natural Killer Cell Proliferation Mucosa-associated Lymphoid Tissue Development Gamma-delta T Cell Differentiation Natural Killer Cell Proliferation Peyer's Patch Development Luteinization Progesterone Metabolic Process Response To Interleukin-2 Positive Regulation Of Natural Killer Cell Proliferation Erythropoietin-mediated Signaling Pathway Negative Regulation Of Erythrocyte Differentiation Activated T Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Development Of Secondary Sexual Characteristics Development Of Secondary Male Sexual Characteristics Mast Cell Migration Regulation Of Natural Killer Cell Differentiation Regulation Of Gamma-delta T Cell Differentiation DNA Replication Origin Binding Growth Hormone Receptor Signaling Pathway Via JAK-STAT Myeloid Cell Apoptotic Process Positive Regulation Of B Cell Differentiation Natural Killer Cell Differentiation Gamma-delta T Cell Activation Negative Regulation Of Myeloid Cell Apoptotic Process Positive Regulation Of Natural Killer Cell Activation Growth Hormone Receptor Signaling Pathway C21-steroid Hormone Metabolic Process DNA Replication Initiation Positive Regulation Of Activated T Cell Proliferation Sex Differentiation Response To Interleukin-4 Chromatin Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Multicellular Organism Growth T Cell Homeostasis Regulation Of Myeloid Cell Apoptotic Process Lipid Storage Regulation Of B Cell Differentiation Positive Regulation Of Interleukin-2 Production
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