ORC5 and DMRTA1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		ORC5	DMRTA1
Gene Name		origin recognition complex, subunit 5	DMRT-like family A1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytoplasm	Nucleus
	Molecular Function	Nucleotide Binding Molecular_function DNA Replication Origin Binding Protein Binding ATP Binding	Core Promoter Proximal Region Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Homodimerization Activity Metal Ion Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Replication Initiation	Ovarian Follicle Development Transcription, DNA-templated Regulation Of Transcription, DNA-templated Sex Differentiation Male Mating Behavior
Pathways		G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition Assembly of the ORC complex at the origin of replication Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin E2F-enabled inhibition of pre-replication complex formation Cell Cycle Checkpoints Association of licensing factors with the pre-replicative complex CDT1 association with the CDC6:ORC:origin complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		29 interactors: CALCOCO2 CDC45 CDC5L CDC6 CDC7 DBF4 DMRTA1 HIST3H3 HIST4H4 KRT18 LAMB2 MCM2 MCM3 MCM4 MCM5 MCM7 NIF3L1 NONO ORC1 ORC2 ORC3 ORC4 ORC6 RPA2 SIPA1L2 STAB1 TAX1BP1 TXNDC11 UBQLN4	2 interactors: ORC5 STAT5B
Entrez ID		5001	63951
HPRD ID		09086	10913
Ensembl ID		ENSG00000164815
Uniprot IDs		A4D0P7 O43913 Q53FC8	Q5VZB9
PDB IDs
Enriched GO Terms of Interacting Partners?		G1/S Transition Of Mitotic Cell Cycle DNA Replication Initiation Mitotic Cell Cycle Phase Transition DNA Replication Cell Cycle Phase Transition DNA-dependent DNA Replication DNA Metabolic Process Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cell Cycle Process DNA Duplex Unwinding DNA Geometric Change Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process DNA Conformation Change Biosynthetic Process DNA Unwinding Involved In DNA Replication Double-strand Break Repair Via Break-induced Replication Chromosome Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Protein-DNA Complex Assembly Positive Regulation Of Cell Cycle Phase Transition Cellular Response To Stress Cellular Response To DNA Damage Stimulus DNA Replication Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Mitotic Cell Cycle Phase Transition Cell Cycle Checkpoint DNA Recombination Cellular Metabolic Process Regulation Of Cell Cycle Process Response To Stress Nuclear DNA Replication Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Cellular Response To Epidermal Growth Factor Stimulus Regulation Of G1/S Transition Of Mitotic Cell Cycle	Creatinine Metabolic Process Development Of Secondary Male Sexual Characteristics Isoleucine Metabolic Process Allantoin Metabolic Process Positive Regulation Of Natural Killer Cell Proliferation Taurine Metabolic Process Regulation Of Natural Killer Cell Proliferation Prolactin Signaling Pathway Response To Interleukin-15 Positive Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Valine Metabolic Process Creatine Metabolic Process Positive Regulation Of Gamma-delta T Cell Activation Succinate Metabolic Process Response To Interleukin-2 Development Of Secondary Female Sexual Characteristics Positive Regulation Of Natural Killer Cell Differentiation Regulation Of Gamma-delta T Cell Differentiation Development Of Secondary Sexual Characteristics Luteinization Positive Regulation Of Interleukin-2 Biosynthetic Process 2-oxoglutarate Metabolic Process Positive Regulation Of B Cell Differentiation Oxaloacetate Metabolic Process Peyer's Patch Development Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Immunity Natural Killer Cell Differentiation Progesterone Metabolic Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Activated T Cell Proliferation Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Interleukin-2 Biosynthetic Process Growth Hormone Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Activation Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Growth Hormone Stimulus Response To Epidermal Growth Factor C21-steroid Hormone Metabolic Process Regulation Of B Cell Differentiation DNA Replication Initiation Positive Regulation Of Interleukin-2 Production Regulation Of Erythrocyte Differentiation Regulation Of Activated T Cell Proliferation T Cell Homeostasis Acute-phase Response Lipid Storage Response To Growth Hormone
Tagcloud ?			aldh1a1 asct beadchip carries cep192 cpeb1 detoxification dhrs7c fbn2 flj35282 grades gwas humanomni1 illumina interrupted jph3 linc00692 looked melphalan mucositis om predisposition quad sequelae snps tt2 tt3 tt4 v1
Tagcloud (Difference) ?			aldh1a1 asct beadchip carries cep192 cpeb1 detoxification dhrs7c fbn2 flj35282 grades gwas humanomni1 illumina interrupted jph3 linc00692 looked melphalan mucositis om predisposition quad sequelae snps tt2 tt3 tt4 v1
Tagcloud (Intersection) ?