ORC5 and STAB1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ORC5	STAB1
Description		origin recognition complex subunit 5	stabilin 1
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Chromosome Cytosol	Plasma Membrane Membrane Endocytic Vesicle Membrane
	Molecular Function	Nucleotide Binding DNA Replication Origin Binding Protein Binding ATP Binding	Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Calcium Ion Binding Protein Binding Hyaluronic Acid Binding Protein-disulfide Reductase Activity Low-density Lipoprotein Particle Binding
	Biological Process	DNA Replication DNA Replication Initiation Regulation Of DNA Replication	Endocytosis Receptor-mediated Endocytosis Inflammatory Response Cell Adhesion Cell-cell Signaling Negative Regulation Of Angiogenesis Defense Response To Bacterium
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	Scavenging by Class H Receptors
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Night sleep phenotypes ( 27126917) Sucrose liking ( 31005972)	A body shape index ( 34021172) Adiponectin levels ( 31178129) Apolipoprotein A1 levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) Colon cancer ( 33632709) Cortical surface area (MOSTest) ( 32665545) Distal colorectal cancer ( 33632709) Diverticular disease ( 30177863) HDL cholesterol ( 24097068) HDL cholesterol levels ( 28334899) Height ( 31562340) Hematocrit ( 27863252) Hodgkin's lymphoma ( 34216518) Intelligence (MTAG) ( 29326435) Iron status biomarkers (ferritin levels) ( 33536631) Parkinson's disease ( 28892059) Schizophrenia ( 29483656 25056061 23974872) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urinary albumin-to-creatinine ratio ( 31511532) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		31 interacting genes: CALCOCO2 CDC45 CDC5L CDC6 CDC7 CEBPA DBF4 DMRTA1 H3-4 H4C16 KRT18 LAMB2 MCM2 MCM3 MCM4 MCM5 MCM7 NIF3L1 NONO ORC1 ORC2 ORC3 ORC4 ORC6 RPA2 SIPA1L2 STAB1 TAX1BP1 TXNDC11 UBQLN4 USP2	8 interacting genes: CHID1 DYRK1A GGA1 GGA2 GGA3 NUFIP2 ORC5 PIK3R2
Entrez ID		5001	23166
HPRD ID		09086	09778
Ensembl ID		ENSG00000164815	ENSG00000010327
Uniprot IDs		A4D0P7 O43913 Q53FC8	Q9NY15
PDB IDs		5UJ7 5UJM 7CTE 7CTF 7CTG 7JPO 7JPP 7JPQ 7JPR 7JPS 8RWV 8S0C 8S0D 8S0E 8S0F
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation DNA Replication DNA Replication Origin Binding DNA Metabolic Process Double-strand Break Repair Via Break-induced Replication Chromosome, Telomeric Region Nuclear Origin Of Replication Recognition Complex CMG Complex Origin Recognition Complex Regulation Of DNA Replication MCM Complex Regulation Of DNA-templated DNA Replication Initiation Nucleic Acid Metabolic Process Double-strand Break Repair Via Homologous Recombination Recombinational Repair Single-stranded DNA Helicase Activity DNA Recombination Regulation Of DNA Metabolic Process DNA Repair Single-stranded DNA Binding Nucleobase-containing Compound Metabolic Process Double-strand Break Repair Chromosome Nucleoplasm Mitotic DNA Replication Initiation DNA Damage Response Nucleus DNA Binding DNA Strand Elongation Involved In DNA Replication DNA Replication Preinitiation Complex Helicase Activity DNA Replication Checkpoint Signaling DNA Strand Elongation Macromolecule Metabolic Process Cellular Response To Stress Regulation Of Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cell Cycle DNA Helicase Activity ATP Hydrolysis Activity Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Mitotic DNA Replication Checkpoint Signaling Nucleolus DNA Replication Factor A Complex 3'-5' DNA Helicase Activity Regulation Of Nuclear Cell Cycle DNA Replication Regulation Of Cell Cycle Process	Golgi To Plasma Membrane Protein Transport Protein Localization To Cell Surface Establishment Of Protein Localization To Membrane Establishment Of Protein Localization To Plasma Membrane Trans-Golgi Network Golgi To Plasma Membrane Transport Ubiquitin Binding Post-Golgi Vesicle-mediated Transport Phosphatidylinositol Binding Vesicle-mediated Transport To The Plasma Membrane Localization Within Membrane Intracellular Protein Transport Protein Localization To Plasma Membrane Early Endosome Membrane Regulation Of Amyloid-beta Formation Protein Transport Protein Localization To Cell Periphery Regulation Of Amyloid Precursor Protein Catabolic Process Histone H3T45 Kinase Activity Establishment Of Protein Localization Endosome Membrane Small GTPase Binding Golgi Vesicle Transport Protein Localization To Membrane Regulation Of Amide Metabolic Process Actin Filament Ribonucleoprotein Complex Regulation Of Supramolecular Fiber Organization Endoplasmic Reticulum Signal Peptide Binding Regulation Of Protein-containing Complex Assembly Negative Regulation Of Heterochromatin Formation Negative Regulation Of Protein-containing Complex Assembly Regulation Of Neurofibrillary Tangle Assembly Splicing Factor Binding Origin Recognition Complex Regulation Of Actin Filament Polymerization Regulation Of Actin Polymerization Or Depolymerization Intracellular Protein Localization Regulation Of Actin Filament Length 1-phosphatidylinositol-3-kinase Regulator Activity Signal Recognition Particle SRP-dependent Cotranslational Protein Targeting To Membrane, Signal Sequence Recognition Box C/D Methylation Guide SnoRNP Complex Regulation Of Microvillus Length Anion Binding Positive Regulation Of Lysosomal Protein Catabolic Process Regulation Of Cytoskeleton Organization Negative Regulation Of Cytoskeleton Organization Negative Regulation Of Supramolecular Fiber Organization 7S RNA Binding
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