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ORC5 and NONO
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
ORC5
NONO
Description
origin recognition complex subunit 5
non-POU domain containing octamer binding
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Origin Recognition Complex
Nucleus
Nucleoplasm
Nuclear Origin Of Replication Recognition Complex
Chromosome
Cytosol
Fibrillar Center
Nucleus
Nucleoplasm
Chromosome
Nucleolus
Membrane
Nuclear Matrix
Nuclear Speck
Paraspeckles
RNA Polymerase II Transcription Regulator Complex
Molecular Function
Nucleotide Binding
DNA Replication Origin Binding
Protein Binding
ATP Binding
Nucleic Acid Binding
DNA Binding
Chromatin Binding
RNA Binding
Protein Binding
Identical Protein Binding
LncRNA Binding
Biological Process
DNA Replication
DNA Replication Initiation
Regulation Of DNA Replication
Activation Of Innate Immune Response
Immune System Process
DNA Repair
DNA Recombination
Regulation Of DNA-templated Transcription
MRNA Processing
DNA Damage Response
Circadian Rhythm
RNA Splicing
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Innate Immune Response
Negative Regulation Of DNA-templated Transcription
Rhythmic Process
Cellular Response To Hypoxia
Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Cellular Response To Angiotensin
Pathways
E2F-enabled inhibition of pre-replication complex formation
Activation of ATR in response to replication stress
Assembly of the ORC complex at the origin of replication
CDC6 association with the ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Drugs
Diseases
GWAS
Alcohol consumption (drinks per week) (
30643258
)
Night sleep phenotypes (
27126917
)
Sucrose liking (
31005972
)
Interacting Genes
31 interacting genes:
CALCOCO2
CDC45
CDC5L
CDC6
CDC7
CEBPA
DBF4
DMRTA1
H3-4
H4C16
KRT18
LAMB2
MCM2
MCM3
MCM4
MCM5
MCM7
NIF3L1
NONO
ORC1
ORC2
ORC3
ORC4
ORC6
RPA2
SIPA1L2
STAB1
TAX1BP1
TXNDC11
UBQLN4
USP2
124 interacting genes:
APBB1
AR
BHLHE41
C11orf68
CA2
CDK1
CEBPA
DANCR
DDX6
DELEC1
ERCC6
ERG
ESR1
EWSR1
FXR2
H3-4
IL7R
IRAK3
LINC00624
LMO4
MAD1L1
MIR1-1
MIR1-2
MIR106A
MIR106B
MIR107
MIR10B
MIR122
MIR128-1
MIR128-2
MIR138-1
MIR138-2
MIR140
MIR141
MIR143
MIR145
MIR155
MIR15A
MIR15B
MIR16-1
MIR16-2
MIR17
MIR18A
MIR18B
MIR199A1
MIR199A2
MIR19A
MIR19B1
MIR19B2
MIR200A
MIR200B
MIR200C
MIR205
MIR206
MIR20A
MIR20B
MIR21
MIR214
MIR221
MIR222
MIR25
MIR29A
MIR29B1
MIR29B2
MIR29C
MIR31
MIR34A
MIR34B
MIR34C
MIR363
MIR429
MIR451A
MIR7-1
MIR7-2
MIR7-3
MIR9-1
MIR9-2
MIR9-3
MIR92A1
MIR92A2
MIR93
MIR98
MIRLET7A1
MIRLET7A2
MIRLET7A3
MIRLET7B
MIRLET7C
MIRLET7D
MIRLET7E
MIRLET7F1
MIRLET7F2
MIRLET7G
MIRLET7I
MYC
MYCN
OGT
ORC5
OTUD5
PDE4B
PIN1
PLEKHF2
POLR1H
POLR2A
PPP1CA
PPP1CB
PPP1CC
PRKAA2
PRPF40A
PSPC1
PTBP1
RNF8
SAMHD1
SFPQ
SMARCB1
SMARCC1
SMARCD1
SPI1
SUMO2
SYNPO
TAFAZZIN
TCERG1
UBE2I
USP11
WBP4
Entrez ID
5001
4841
HPRD ID
09086
02098
Ensembl ID
ENSG00000164815
ENSG00000147140
Uniprot IDs
A4D0P7
O43913
Q53FC8
A0A0S2Z4Z9
Q15233
PDB IDs
5UJ7
5UJM
7CTE
7CTF
7CTG
7JPO
7JPP
7JPQ
7JPR
7JPS
8RWV
8S0C
8S0D
8S0E
8S0F
3SDE
5IFM
6WMZ
7LRQ
7LRU
7PU5
Enriched GO Terms of Interacting Partners
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DNA Replication Initiation
DNA Replication
DNA Replication Origin Binding
DNA Metabolic Process
Double-strand Break Repair Via Break-induced Replication
Chromosome, Telomeric Region
Nuclear Origin Of Replication Recognition Complex
CMG Complex
Origin Recognition Complex
Regulation Of DNA Replication
MCM Complex
Regulation Of DNA-templated DNA Replication Initiation
Nucleic Acid Metabolic Process
Double-strand Break Repair Via Homologous Recombination
Recombinational Repair
Single-stranded DNA Helicase Activity
DNA Recombination
Regulation Of DNA Metabolic Process
DNA Repair
Single-stranded DNA Binding
Nucleobase-containing Compound Metabolic Process
Double-strand Break Repair
Chromosome
Nucleoplasm
Mitotic DNA Replication Initiation
DNA Damage Response
Nucleus
DNA Binding
DNA Strand Elongation Involved In DNA Replication
DNA Replication Preinitiation Complex
Helicase Activity
DNA Replication Checkpoint Signaling
DNA Strand Elongation
Macromolecule Metabolic Process
Cellular Response To Stress
Regulation Of Cell Cycle Phase Transition
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Cell Cycle
DNA Helicase Activity
ATP Hydrolysis Activity
Negative Regulation Of Cell Cycle Phase Transition
Positive Regulation Of Nuclear Cell Cycle DNA Replication
Regulation Of Cell Cycle
Negative Regulation Of Cell Cycle Process
Mitotic DNA Replication Checkpoint Signaling
Nucleolus
DNA Replication Factor A Complex
3'-5' DNA Helicase Activity
Regulation Of Nuclear Cell Cycle DNA Replication
Regulation Of Cell Cycle Process
MiRNA-mediated Post-transcriptional Gene Silencing
RISC Complex
Regulatory NcRNA-mediated Post-transcriptional Gene Silencing
Post-transcriptional Gene Silencing
Regulatory NcRNA-mediated Gene Silencing
MRNA Base-pairing Post-transcriptional Repressor Activity
Post-transcriptional Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
MRNA 3'-UTR Binding
MiRNA-mediated Gene Silencing By Inhibition Of Translation
Negative Regulation Of Metabolic Process
MiRNA-mediated Gene Silencing By MRNA Destabilization
Regulation Of Gene Expression
Regulation Of Macromolecule Biosynthetic Process
Extracellular Vesicle
Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Translation
Regulation Of Metabolic Process
MRNA Destabilization
RNA Destabilization
Positive Regulation Of MRNA Catabolic Process
Negative Regulation Of Cytokine Production
Negative Regulation Of Cell Motility
Positive Regulation Of MRNA Metabolic Process
Negative Regulation Of Vascular Endothelial Growth Factor Production
Regulation Of Translation
Negative Regulation Of Developmental Process
Negative Regulation Of Cell Migration
Negative Regulation Of Locomotion
Negative Regulation Of Angiogenesis
Negative Regulation Of Vasculature Development
Negative Regulation Of Signal Transduction
Negative Regulation Of Multicellular Organismal Process
Negative Regulation Of Protein Metabolic Process
Regulation Of Angiogenesis
Negative Regulation Of Signaling
Negative Regulation Of Cell Communication
Regulation Of Vasculature Development
Regulation Of MRNA Stability
Regulation Of RNA Stability
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Developmental Process
Regulation Of Blood Vessel Endothelial Cell Migration
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Cellular Response To Growth Factor Stimulus
Negative Regulation Of Blood Vessel Endothelial Cell Migration
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