NLRP6

Description		NLR family pyrin domain containing 6
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Nuclear Membrane Membraneless Organelle Canonical Inflammasome Complex NLRP6 Inflammasome Complex
	Molecular Function	Nucleotide Binding Lipopolysaccharide Binding Double-stranded RNA Binding Vasopressin Receptor Activity ATP Binding Signaling Adaptor Activity Signaling Receptor Activity Pattern Recognition Receptor Activity Peptide Binding Lipoteichoic Acid Binding Molecular Condensate Scaffold Activity
	Biological Process	Immune System Process Acute Inflammatory Response To Antigenic Stimulus Acute Inflammatory Response Negative Regulation Of Inflammatory Response To Antigenic Stimulus Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Protein Secretion Response To Bacterium Regulation Of Autophagy Negative Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-18 Production Negative Regulation Of Toll-like Receptor Signaling Pathway Interleukin-18-mediated Signaling Pathway Wound Healing Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of MAPK Cascade Innate Immune Response Host-mediated Modulation Of Intestinal Microbiota Composition Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Negative Regulation Of Immune Response Defense Response To Gram-positive Bacterium Protein Homooligomerization Protein Maturation Defense Response To Virus Regulation Of Mucus Secretion Necroptotic Process Pyroptotic Inflammatory Response Negative Regulation Of ERK1 And ERK2 Cascade Interleukin-1-mediated Signaling Pathway Neutrophil-mediated Killing Of Gram-positive Bacterium Antiviral Innate Immune Response NLRP6 Inflammasome Complex Assembly Positive Regulation Of Interleukin-18-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS		Mean platelet volume ( 22139419) Platelet count ( 22139419) Reticulocyte count ( 32888494)
Interacting Genes		6 interacting genes: ATG12 ATG16L1 ATG5 BECN1 PIK3R1 SQSTM1
Entrez ID		171389
HPRD ID		14806
Ensembl ID		ENSG00000174885
Uniprot IDs		P59044
PDB IDs		6NCV 6NDJ
Enriched GO Terms of Interacting Partners?		Autophagosome Macroautophagy Atg12-Atg5-Atg16 Complex Autophagy Of Mitochondrion Autophagy Autophagosome Assembly Autophagosome Organization Regulation Of Autophagy Phagophore Assembly Site Membrane Microautophagy Regulation Of Innate Immune Response Positive Regulation Of Viral Translation Vacuole Organization Positive Regulation Of Autophagy Atg8-family Ligase Activity Negative Stranded Viral RNA Replication Organelle Assembly Mitophagy Regulation Of Defense Response Response To Mitochondrial Depolarisation Response To Iron(II) Ion Positive Regulation Of Stress Granule Assembly Viral RNA Genome Replication Regulation Of Immune Response Cellular Response To Nitrogen Starvation Regulation Of Stress Granule Assembly Transferase Complex Regulation Of Cellular Component Organization Intracellular Transport Regulation Of Organelle Organization Aggrephagy Regulation Of Autophagosome Maturation Negative Regulation Of Immune System Process Phosphatidylinositol 3-kinase Binding Negative Regulation Of Defense Response To Virus Positive Regulation Of Catabolic Process Piecemeal Microautophagy Of The Nucleus Viral Genome Replication Nucleophagy Regulation Of Macroautophagy Cellular Localization Establishment Of Localization In Cell Regulation Of Immune System Process Phagophore Assembly Site Response To Iron Ion Regulation Of Toll-like Receptor 4 Signaling Pathway GTPase Binding Defense Response To Virus Nucleobase-containing Compound Biosynthetic Process Catabolic Process
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