IER3 and PRNP

Number of citations of the paper that reports this interaction (PMID 18482256)
4

Data Source:
BioGRID (pull down)

		IER3	PRNP
Gene Name		immediate early response 3	prion protein
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Integral Component Of Membrane	Nucleus Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Cell Surface Integral Component Of Membrane Extrinsic Component Of Membrane Anchored Component Of Membrane Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Protein Binding	Copper Ion Binding Protein Binding Microtubule Binding Tubulin Binding Identical Protein Binding ATP-dependent Protein Binding Chaperone Binding
	Biological Process	Response To Protozoan Negative Regulation Of Systemic Arterial Blood Pressure Regulation Of DNA Repair Apoptotic Process Mitotic G2 DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Anatomical Structure Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Glycolytic Process Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Inflammatory Response Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Response To DNA Damage Stimulus	Negative Regulation Of Protein Phosphorylation Cellular Copper Ion Homeostasis Response To Oxidative Stress Cell Cycle Arrest Axon Guidance Learning Or Memory Metabolic Process Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-2 Production Regulation Of Protein Localization Negative Regulation Of Apoptotic Process Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Activated T Cell Proliferation Response To Cadmium Ion Negative Regulation Of T Cell Receptor Signaling Pathway Protein Homooligomerization Negative Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To Copper Ion Regulation Of Potassium Ion Transmembrane Transport
Pathways			NCAM1 interactions Axon guidance NCAM signaling for neurite out-growth
Drugs			Tetracycline
Diseases
GWAS		Age-related macular degeneration ( 23455636) Ulcerative colitis ( 20848476)	Creutzfeldt-Jakob disease ( 19081515) Creutzfeldt-Jakob disease (variant) ( 22137330) Platelet aggregation ( 20526338) Prion diseases ( 22210626)
Protein-Protein Interactions		6 interactors: APP MAPK1 MAPK3 PPP2R5B PPP2R5C PRNP	76 interactors: ABT1 ADAM23 ADAP2 AGO1 AIFM3 APBB1 APLP1 APLP2 APOE ARHGAP15 BAG6 BAZ2B C7orf50 CAV1 CCDC149 CIRBP CIRH1A CLSTN1 CLU CNP CNTN1 CSN3 CSNK2A1 CSNK2A2 CSNK2B CWC15 DDX47 DNM1 DPP6 DYRK3 ERI3 FAM27E3 FGF13 FHL1 GRB2 HSPA5 HSPD1 IER3 KIAA1191 L1CAM LSAMP MAG MARK4 MOG MTG1 NCAM1 NCAM2 NHP2 NOB1 OPCML P4HB PDE4DIP PLG PPFIBP2 PPP1R14A PSMA3 PTRH1 PVRL1 RBM22 RNPC3 RPL41 SCNM1 SPARCL1 STIP1 SURF2 TBPL1 TMEM237 TSC22D4 TSLP TYMSOS WDR5 WIBG ZFYVE28 ZKSCAN8 ZNF408 ZNF740
Entrez ID		8870	5621
HPRD ID		04295	01453
Ensembl ID		ENSG00000137331	ENSG00000171867
Uniprot IDs		P46695	B2NI04 F7VJQ1 P04156 Q53YK7
PDB IDs			1E1G 1E1J 1E1P 1E1S 1E1U 1E1W 1FKC 1FO7 1H0L 1HJM 1HJN 1I4M 1OEH 1OEI 1QLX 1QLZ 1QM0 1QM1 1QM2 1QM3 2IV4 2IV5 2IV6 2K1D 2KUN 2LBG 2LEJ 2LFT 2LSB 2LV1 2M8T 2OL9 2W9E 3HAF 3HAK 3HEQ 3HER 3HES 3HJ5 3HJX 3MD4 3MD5 3NHC 3NHD 3NVF 4DGI 4E1H 4E1I
Enriched GO Terms of Interacting Partners?		Regulation Of Golgi Inheritance Caveolin-mediated Endocytosis Axon Guidance Regulation Of Protein Phosphorylation Regulation Of Golgi Organization Regulation Of Phosphorylation Regulation Of Early Endosome To Late Endosome Transport Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Phosphorus Metabolic Process Chemotaxis Neuron Projection Morphogenesis Cellular Copper Ion Homeostasis Response To Stress Platelet Activation Cell Morphogenesis Involved In Differentiation Copper Ion Homeostasis JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Protein Kinase Activity Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Regulation Of Kinase Activity Neuron Projection Development Response To Epidermal Growth Factor Regulation Of Cellular Response To Heat Regulation Of Cellular Protein Metabolic Process Cell Projection Morphogenesis Cell Part Morphogenesis Lipopolysaccharide-mediated Signaling Pathway Neuron Development Regulation Of Protein Metabolic Process Apoptotic Process Response To Growth Hormone Programmed Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cell Death Death Cell Morphogenesis Regulation Of Catalytic Activity Response To Exogenous DsRNA Positive Regulation Of Cellular Protein Metabolic Process Neuron Differentiation Toll-like Receptor 5 Signaling Pathway JAK-STAT Cascade Toll-like Receptor 10 Signaling Pathway Cell Projection Organization Neurological System Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway	Nervous System Development System Development Anatomical Structure Development Axon Development Developmental Process Multicellular Organismal Development Neurogenesis Axon Guidance Generation Of Neurons Axonogenesis Neuron Development Neuron Projection Development Neuron Differentiation Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Regulation Of Protein Metabolic Process Central Nervous System Development Cell Projection Organization Cell Differentiation Cell Projection Morphogenesis Posttranscriptional Regulation Of Gene Expression Cell Part Morphogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Cellular Process Negative Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Chemotaxis Cell Morphogenesis Anatomical Structure Morphogenesis Positive Regulation Of Neurofibrillary Tangle Assembly Locomotion RNA Metabolic Process Apoptotic Process Gene Expression MRNA Metabolic Process Cell Adhesion Programmed Cell Death Cell Death Death Cell Development Response To External Stimulus Movement Of Cell Or Subcellular Component Regulation Of Tau-protein Kinase Activity Extracellular Matrix Organization Extracellular Structure Organization Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Proteolysis Midbrain Development Regulation Of Protein Catabolic Process Protein Stabilization
Tagcloud ?		aml axl cd33 cfos cox2 dissect exerts favor gc haematopoietic hdaci hl60 interferes k562 leukaemia leukemic mithramycin modulated neoplastic p15 potentiated proximal quantified rai3 rich sheds sp1 thp vorinostat	chelation cooperatively copper cysteines excitotoxicity exert favor glun1 glun2a glutamatergic hippocampi indeed innovation insults interdependent modulates mounting neurodegeneration neuroprotection nitric nitrosylation nmdar organotypic oxide prion prnp0 prpc synapses thiols
Tagcloud (Difference) ?		aml axl cd33 cfos cox2 dissect exerts gc haematopoietic hdaci hl60 interferes k562 leukaemia leukemic mithramycin modulated neoplastic p15 potentiated proximal quantified rai3 rich sheds sp1 thp vorinostat	chelation cooperatively copper cysteines excitotoxicity exert glun1 glun2a glutamatergic hippocampi indeed innovation insults interdependent modulates mounting neurodegeneration neuroprotection nitric nitrosylation nmdar organotypic oxide prion prnp0 prpc synapses thiols
Tagcloud (Intersection) ?		favor