IER3 and FKBP7

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IER3	FKBP7
Description		immediate early response 3	FKBP prolyl isomerase 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Cytosol Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen
	Molecular Function	Protein Binding	Peptidyl-prolyl Cis-trans Isomerase Activity Calcium Ion Binding Protein Binding FK506 Binding Isomerase Activity Metal Ion Binding
	Biological Process	Response To Protozoan Negative Regulation Of Systemic Arterial Blood Pressure Glycolytic Process Regulation Of DNA Repair Apoptotic Process DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Anatomical Structure Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Glycolytic Process Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Inflammatory Response Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23455636) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 30804561) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Serum alkaline phosphatase levels ( 33547301) Sleep duration ( 25469926) Small cell lung carcinoma ( 28604730) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 20848476)	Alanine aminotransferase levels ( 33547301) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 33547301) Atrial fibrillation ( 30061737) Blood protein levels ( 30072576) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183) Refractive error ( 32231278)
Interacting Genes		17 interacting genes: APP AQP2 CD79A CISD2 FHL2 FKBP7 GLP1R MAPK1 MAPK3 MDM2 PPP2R5B PPP2R5C PRNP SGTA SLC13A4 TMBIM6 TMX2	107 interacting genes: ABHD16A ADGRE2 ADIPOQ AP1M1 APOD ASPH BET1 BMP10 BRICD5 C3orf52 CD81 CDIPT CDS2 CERCAM CFTR CIAO2A CLCA4 CLDN19 CNIH1 CTSA CXCL16 CYB561D2 CYB5B DIABLO ERMP1 FAM3C FARS2 GET3 H4C7 HHATL HMOX1 HSBP1L1 HTATIP2 IER3 IFITM3 IGFBP5 IRF2 JOSD2 LAT LNPEP MAN2B2 MIEF2 MRM1 NFU1 NKG7 NPFFR2 OCIAD1 OXNAD1 PBX3 PCYT1A PEX16 PEX19 PLLP PLP1 PLP2 PLPP6 PPIF PRMT6 PTCD1 PTPN9 RBFA RPRM RUSF1 SELENOK SERP1 SGTA SLC30A3 SLC38A7 SLC7A14 SNX1 SNX12 STATH STX7 STX8 SUCLA2 TARS2 TCP11X2 TECR TF THAP4 THSD7B TMEM108 TMEM120B TMEM147 TMEM14A TMEM229B TMEM239 TMEM54 TMEM86A TMEM86B TMEM97 TRAM1L1 TSPAN2 TSPO2 TTPA TXNDC12 UBIAD1 UBQLN4 UNC93B1 UPK1B UPK2 VSTM4 WFDC2 WIPI2 YIPF4 YIPF6 ZFPL1
Entrez ID		8870	51661
HPRD ID		04295	08451
Ensembl ID		ENSG00000137331	ENSG00000079150
Uniprot IDs		A0A1U9X7X2 P46695	B4DRE2 Q9Y680
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Copper Ion Interleukin-34-mediated Signaling Pathway Response To Copper Ion Response To Growth Factor Regulation Of Cellular Response To Stress Negative Regulation Of Proteolysis Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Positive Regulation Of Macrophage Proliferation Identical Protein Binding Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Intracellular Monoatomic Cation Homeostasis Regulation Of Proteolysis Glial Cell Development Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Intracellular Monoatomic Ion Homeostasis Bergmann Glial Cell Differentiation Negative Regulation Of Long-term Synaptic Potentiation Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Mononuclear Cell Migration Regulation Of Response To Endoplasmic Reticulum Stress Intracellular Copper Ion Homeostasis Positive Regulation Of Leukocyte Chemotaxis Regulation Of Calcium-mediated Signaling Negative Regulation Of Calcineurin-NFAT Signaling Cascade Protein Phosphatase Type 2A Complex MAP Kinase Activity Chemical Homeostasis Learning Or Memory Intracellular Chemical Homeostasis Regulation Of Cellular Localization Regulation Of Golgi Organization Pseudopodium Protein Phosphatase Activator Activity Regulation Of Early Endosome To Late Endosome Transport Copper Ion Homeostasis Schwann Cell Development Endoplasmic Reticulum Lumen Positive Regulation Of Macrophage Chemotaxis Negative Regulation Of Calcium-mediated Signaling Positive Regulation Of Neuroinflammatory Response Animal Organ Formation Positive Regulation Of Cyclase Activity	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Protein Binding Chloride Channel Inhibitor Activity Regulation Of Cellular Localization Cellular Localization Protein Insertion Into ER Membrane Transferrin Receptor Binding Alkenylglycerophosphocholine Hydrolase Activity Lysosome Peroxisome Membrane Biogenesis Intraciliary Transport Particle B Binding Cholesterol Binding Establishment Of Localization In Cell
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