IER3 and PPP2R5C

Number of citations of the paper that reports this interaction (PMID 16456541)
37

Data Source:
HPRD (in vitro)

		IER3	PPP2R5C
Gene Name		immediate early response 3	protein phosphatase 2, regulatory subunit B, gamma
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Integral Component Of Membrane	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus
	Molecular Function	Protein Binding	Protein Binding Protein Phosphatase Type 2A Regulator Activity
	Biological Process	Response To Protozoan Negative Regulation Of Systemic Arterial Blood Pressure Regulation Of DNA Repair Apoptotic Process Mitotic G2 DNA Damage Checkpoint Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Anatomical Structure Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Glycolytic Process Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Inflammatory Response Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Response To DNA Damage Stimulus	DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Negative Regulation Of Cell Proliferation Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Catalytic Activity
Pathways			Mitotic Prometaphase Costimulation by the CD28 family Separation of Sister Chromatids misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Mitotic Anaphase Signaling by Wnt M Phase APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Degradation of beta-catenin by the destruction complex S37 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling CTLA4 inhibitory signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Cell Cycle, Mitotic Platelet homeostasis deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT Platelet sensitization by LDL AMER1 mutants destabilize the destruction complex Resolution of Sister Chromatid Cohesion deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23455636) Ulcerative colitis ( 20848476)	Autism ( 20663923)
Protein-Protein Interactions		6 interactors: APP MAPK1 MAPK3 PPP2R5B PPP2R5C PRNP	14 interactors: APP AXIN1 BRCA1 CHEK2 EP300 IER3 MAPK1 MBP PAXIP1 PPP2CA PPP2R1B PRKCD PXN SGOL1
Entrez ID		8870	5527
HPRD ID		04295	03385
Ensembl ID		ENSG00000137331	ENSG00000078304
Uniprot IDs		P46695	Q13362
PDB IDs			2IAE 2JAK 2NPP 2NYL 2NYM 3FGA
Enriched GO Terms of Interacting Partners?		Regulation Of Golgi Inheritance Caveolin-mediated Endocytosis Axon Guidance Regulation Of Protein Phosphorylation Regulation Of Golgi Organization Regulation Of Phosphorylation Regulation Of Early Endosome To Late Endosome Transport Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Phosphorus Metabolic Process Chemotaxis Neuron Projection Morphogenesis Cellular Copper Ion Homeostasis Response To Stress Platelet Activation Cell Morphogenesis Involved In Differentiation Copper Ion Homeostasis JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Protein Kinase Activity Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Regulation Of Kinase Activity Neuron Projection Development Response To Epidermal Growth Factor Regulation Of Cellular Response To Heat Regulation Of Cellular Protein Metabolic Process Cell Projection Morphogenesis Cell Part Morphogenesis Lipopolysaccharide-mediated Signaling Pathway Neuron Development Regulation Of Protein Metabolic Process Apoptotic Process Response To Growth Hormone Programmed Cell Death Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cell Death Death Cell Morphogenesis Regulation Of Catalytic Activity Response To Exogenous DsRNA Positive Regulation Of Cellular Protein Metabolic Process Neuron Differentiation Toll-like Receptor 5 Signaling Pathway JAK-STAT Cascade Toll-like Receptor 10 Signaling Pathway Cell Projection Organization Neurological System Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway	Apoptotic Process Programmed Cell Death Cell Death Death Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cellular Ketone Metabolic Process Cellular Response To Stress Positive Regulation Of Cellular Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway Developmental Process Positive Regulation Of Metabolic Process Response To Stress Positive Regulation Of Cellular Metabolic Process Intracellular Signal Transduction Cell Cycle Regulation Of Cellular Protein Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Protein Modification Process Regulation Of Signal Transduction Regulation Of MAP Kinase Activity Regulation Of Signaling Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Stability Apoptotic Signaling Pathway Cellular Protein Modification Process Signaling Regulation Of Protein Kinase Activity Cell Communication Regulation Of Kinase Activity Regulation Of Cellular Component Organization Positive Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Posttranscriptional Regulation Of Gene Expression Anatomical Structure Development Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Signal Transduction Cell Cycle Process Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Anatomical Structure Morphogenesis Response To Abiotic Stimulus Cellular Protein Metabolic Process Protein Stabilization Signal Transduction In Response To DNA Damage Positive Regulation Of Histone H3-K4 Methylation
Tagcloud ?		aml axl cd33 cfos cox2 dissect exerts favor gc haematopoietic hdaci hl60 interferes k562 leukaemia leukemic mithramycin modulated neoplastic p15 potentiated proximal quantified rai3 rich sheds sp1 thp vorinostat	3beta annexin ataxia atm cck downregulated efficient glycogen gsk homolog interference jurkat leukemias leukemic mdm2 molt nonsilencing nucleofection pi qrt scrambled sirna sirna2 sirnas tcr telangiectasia transfected treat twofold
Tagcloud (Difference) ?		aml axl cd33 cfos cox2 dissect exerts favor gc haematopoietic hdaci hl60 interferes k562 leukaemia mithramycin modulated neoplastic p15 potentiated proximal quantified rai3 rich sheds sp1 thp vorinostat	3beta annexin ataxia atm cck downregulated efficient glycogen gsk homolog interference jurkat leukemias mdm2 molt nonsilencing nucleofection pi qrt scrambled sirna sirna2 sirnas tcr telangiectasia transfected treat twofold
Tagcloud (Intersection) ?		leukemic