IER3 and PPP2R5C

Number of citations of the paper that reports this interaction (PubMedID 16456541)
38

Data Source:
HPRD (in vitro)

		IER3	PPP2R5C
Description		immediate early response 3	protein phosphatase 2 regulatory subunit B'gamma
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Cytosol Membrane	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Golgi Apparatus Cytosol
	Molecular Function	Protein Binding	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity
	Biological Process	Response To Protozoan Negative Regulation Of Systemic Arterial Blood Pressure Glycolytic Process Regulation Of DNA Repair Apoptotic Process DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Anatomical Structure Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Glycolytic Process Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Inflammatory Response Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process	Signal Transduction Negative Regulation Of Cell Population Proliferation DNA Damage Response, Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Meiotic Sister Chromatid Cohesion
Pathways		PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway Regulation of TP53 Degradation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs			2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid (2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid
Diseases
GWAS		Age-related macular degeneration ( 23455636) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 30804561) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Serum alkaline phosphatase levels ( 33547301) Sleep duration ( 25469926) Small cell lung carcinoma ( 28604730) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 20848476)	Anti-saccade response ( 29064472) Autism ( 20663923) Leukoderma in response to rhododendrol ( 32558222) Metabolite levels ( 23823483)
Interacting Genes		17 interacting genes: APP AQP2 CD79A CISD2 FHL2 FKBP7 GLP1R MAPK1 MAPK3 MDM2 PPP2R5B PPP2R5C PRNP SGTA SLC13A4 TMBIM6 TMX2	21 interacting genes: APP ATM AXIN1 BRCA1 BUB1B CHEK2 CIP2A EP300 IER3 MAPK1 MBP OGT PAXIP1 PPP1CA PPP1CB PPP1CC PPP2CA PPP2R1B PRKCD PXN SGO1
Entrez ID		8870	5527
HPRD ID		04295	03385
Ensembl ID		ENSG00000137331	ENSG00000078304
Uniprot IDs		A0A1U9X7X2 P46695	A0A8Q3WKR3 Q13362
PDB IDs			2IAE 2JAK 2NPP 2NYL 2NYM 3FGA 5JJA 5K6S 5SW9 5SWF 6OYL 6TOQ 6VOY 6VRO 7OUF 7OUG 7OUH 7PEL 7SOY
Enriched GO Terms of Interacting Partners?		Cellular Response To Copper Ion Interleukin-34-mediated Signaling Pathway Response To Copper Ion Response To Growth Factor Regulation Of Cellular Response To Stress Negative Regulation Of Proteolysis Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Positive Regulation Of Macrophage Proliferation Identical Protein Binding Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Intracellular Monoatomic Cation Homeostasis Regulation Of Proteolysis Glial Cell Development Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Intracellular Monoatomic Ion Homeostasis Bergmann Glial Cell Differentiation Negative Regulation Of Long-term Synaptic Potentiation Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Mononuclear Cell Migration Regulation Of Response To Endoplasmic Reticulum Stress Intracellular Copper Ion Homeostasis Positive Regulation Of Leukocyte Chemotaxis Regulation Of Calcium-mediated Signaling Negative Regulation Of Calcineurin-NFAT Signaling Cascade Protein Phosphatase Type 2A Complex MAP Kinase Activity Chemical Homeostasis Learning Or Memory Intracellular Chemical Homeostasis Regulation Of Cellular Localization Regulation Of Golgi Organization Pseudopodium Protein Phosphatase Activator Activity Regulation Of Early Endosome To Late Endosome Transport Copper Ion Homeostasis Schwann Cell Development Endoplasmic Reticulum Lumen Positive Regulation Of Macrophage Chemotaxis Negative Regulation Of Calcium-mediated Signaling Positive Regulation Of Neuroinflammatory Response Animal Organ Formation Positive Regulation Of Cyclase Activity	Response To Radiation Regulation Of Carbohydrate Catabolic Process Intracellular Signal Transduction Apoptotic Process Regulation Of Glycolytic Process Programmed Cell Death Regulation Of Small Molecule Metabolic Process Cell Death Regulation Of Generation Of Precursor Metabolites And Energy DNA Damage Response Regulation Of ATP Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Purine Nucleotide Metabolic Process PTW/PP1 Phosphatase Complex Intrinsic Apoptotic Signaling Pathway Regulation Of Organelle Organization Chromosome Cellular Response To Stress Chromosome Organization Protein Modification Process Regulation Of Cellular Response To Stress Regulation Of Cellular Component Organization Cytosol Circadian Rhythm Regulation Of Reactive Oxygen Species Metabolic Process Signal Transduction Regulation Of Intracellular Transport Regulation Of Cell Cycle Phase Transition Cell Division Signal Transduction In Response To DNA Damage RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Circadian Regulation Of Gene Expression Mitotic DNA Damage Checkpoint Signaling Response To Lead Ion Mitotic DNA Integrity Checkpoint Signaling Cellular Response To Radiation Positive Regulation Of Metabolic Process Response To Light Stimulus Regulation Of Mitotic Cell Cycle Chromosome, Telomeric Region Regulation Of Cell Cycle Process Apoptotic Signaling Pathway Entrainment Of Circadian Clock By Photoperiod Regulation Of Cellular Localization Organelle Organization Phosphate-containing Compound Metabolic Process Regulation Of Signal Transduction Regulation Of Cell Cycle Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity
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