IER3

Description		immediate early response 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Cytosol Membrane
	Molecular Function	Protein Binding
	Biological Process	Response To Protozoan Negative Regulation Of Systemic Arterial Blood Pressure Glycolytic Process Regulation Of DNA Repair Apoptotic Process DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Anatomical Structure Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Glycolytic Process Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Inflammatory Response Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23455636) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 30804561) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Serum alkaline phosphatase levels ( 33547301) Sleep duration ( 25469926) Small cell lung carcinoma ( 28604730) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 20848476)
Interacting Genes		17 interacting genes: APP AQP2 CD79A CISD2 FHL2 FKBP7 GLP1R MAPK1 MAPK3 MDM2 PPP2R5B PPP2R5C PRNP SGTA SLC13A4 TMBIM6 TMX2
Entrez ID		8870
HPRD ID		04295
Ensembl ID		ENSG00000137331
Uniprot IDs		A0A1U9X7X2 P46695
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Copper Ion Interleukin-34-mediated Signaling Pathway Response To Copper Ion Response To Growth Factor Regulation Of Cellular Response To Stress Negative Regulation Of Proteolysis Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Positive Regulation Of Macrophage Proliferation Identical Protein Binding Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Intracellular Monoatomic Cation Homeostasis Regulation Of Proteolysis Glial Cell Development Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Intracellular Monoatomic Ion Homeostasis Bergmann Glial Cell Differentiation Negative Regulation Of Long-term Synaptic Potentiation Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Mononuclear Cell Migration Regulation Of Response To Endoplasmic Reticulum Stress Intracellular Copper Ion Homeostasis Positive Regulation Of Leukocyte Chemotaxis Regulation Of Calcium-mediated Signaling Negative Regulation Of Calcineurin-NFAT Signaling Cascade Protein Phosphatase Type 2A Complex MAP Kinase Activity Chemical Homeostasis Learning Or Memory Intracellular Chemical Homeostasis Regulation Of Cellular Localization Regulation Of Golgi Organization Pseudopodium Protein Phosphatase Activator Activity Regulation Of Early Endosome To Late Endosome Transport Copper Ion Homeostasis Schwann Cell Development Endoplasmic Reticulum Lumen Positive Regulation Of Macrophage Chemotaxis Negative Regulation Of Calcium-mediated Signaling Positive Regulation Of Neuroinflammatory Response Animal Organ Formation Positive Regulation Of Cyclase Activity
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