IER3 and PPP2R5B

Number of citations of the paper that reports this interaction (PubMedID 16456541)
38

Data Source:
HPRD (in vitro)

		IER3	PPP2R5B
Description		immediate early response 3	protein phosphatase 2 regulatory subunit B'beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Cytosol Membrane	Protein Phosphatase Type 2A Complex Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding	Protein Binding Protein Phosphatase Regulator Activity Protein Phosphatase Activator Activity
	Biological Process	Response To Protozoan Negative Regulation Of Systemic Arterial Blood Pressure Glycolytic Process Regulation Of DNA Repair Apoptotic Process DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Anatomical Structure Morphogenesis Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Glycolytic Process Regulation Of Nucleocytoplasmic Transport Negative Regulation Of Inflammatory Response Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Reactive Oxygen Species Metabolic Process	Signal Transduction Positive Regulation Of Neuron Projection Development Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cell Cycle Negative Regulation Of G0 To G1 Transition Cellular Response To Growth Factor Stimulus
Pathways		PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion XBP1(S) activates chaperone genes Co-stimulation by CD28 Co-inhibition by CTLA4 Platelet sensitization by LDL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants CTNNB1 S33 mutants aren't phosphorylated CTNNB1 S37 mutants aren't phosphorylated CTNNB1 S45 mutants aren't phosphorylated CTNNB1 T41 mutants aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex RHO GTPases Activate Formins RAF activation Negative regulation of MAPK pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23455636) Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 30804561) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) Rosacea symptom severity ( 29771307) Sarcoidosis (Lofgren's syndrome vs non-Lofgren's syndrome) ( 26651848) Serum alkaline phosphatase levels ( 33547301) Sleep duration ( 25469926) Small cell lung carcinoma ( 28604730) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 20848476)	Serum uric acid levels ( 32514006)
Interacting Genes		17 interacting genes: APP AQP2 CD79A CISD2 FHL2 FKBP7 GLP1R MAPK1 MAPK3 MDM2 PPP2R5B PPP2R5C PRNP SGTA SLC13A4 TMBIM6 TMX2	8 interacting genes: AXIN1 BUB1B CHEK2 IER3 MAPK1 PPP2CA PPP2R1A SGO1
Entrez ID		8870	5526
HPRD ID		04295	09038
Ensembl ID		ENSG00000137331	ENSG00000068971
Uniprot IDs		A0A1U9X7X2 P46695	Q15173
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Copper Ion Interleukin-34-mediated Signaling Pathway Response To Copper Ion Response To Growth Factor Regulation Of Cellular Response To Stress Negative Regulation Of Proteolysis Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Positive Regulation Of Macrophage Proliferation Identical Protein Binding Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Intracellular Monoatomic Cation Homeostasis Regulation Of Proteolysis Glial Cell Development Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Intracellular Monoatomic Ion Homeostasis Bergmann Glial Cell Differentiation Negative Regulation Of Long-term Synaptic Potentiation Neuron Projection Maintenance Regulation Of Dendritic Spine Maintenance Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Modulation Of Chemical Synaptic Transmission Positive Regulation Of Mononuclear Cell Migration Regulation Of Response To Endoplasmic Reticulum Stress Intracellular Copper Ion Homeostasis Positive Regulation Of Leukocyte Chemotaxis Regulation Of Calcium-mediated Signaling Negative Regulation Of Calcineurin-NFAT Signaling Cascade Protein Phosphatase Type 2A Complex MAP Kinase Activity Chemical Homeostasis Learning Or Memory Intracellular Chemical Homeostasis Regulation Of Cellular Localization Regulation Of Golgi Organization Pseudopodium Protein Phosphatase Activator Activity Regulation Of Early Endosome To Late Endosome Transport Copper Ion Homeostasis Schwann Cell Development Endoplasmic Reticulum Lumen Positive Regulation Of Macrophage Chemotaxis Negative Regulation Of Calcium-mediated Signaling Positive Regulation Of Neuroinflammatory Response Animal Organ Formation Positive Regulation Of Cyclase Activity	Chromosome, Centromeric Region Sister Chromatid Cohesion Meiotic Sister Chromatid Cohesion, Centromeric Intracellular Signal Transduction Lateral Plasma Membrane Microtubule Cytoskeleton Regulation Of Organelle Organization Meiotic Sister Chromatid Cohesion Regulation Of Cell Cycle Process Protein Serine Kinase Activity Organelle Organization Cell Death Apoptotic Process Protein Serine/threonine Kinase Activity Regulation Of Cell Cycle Phase Transition Programmed Cell Death Microtubule Cytoskeleton Organization INTAC Complex RNA Polymerase II Transcription Initiation Surveillance FAR/SIN/STRIPAK Complex Negative Regulation Of Glycolytic Process Protein Phosphatase Type 2A Complex Negative Regulation Of Hippo Signaling Negative Regulation Of ATP Metabolic Process Regulation Of Mitotic Cell Cycle Protein Kinase Activity Regulation Of Cell Cycle Signal Transduction Catabolic Process Negative Regulation Of Mitotic Cell Cycle T Cell Homeostasis Nuclear RNA Surveillance Kinase Activity Negative Regulation Of Cell Cycle Phase Transition RNA Surveillance Tau Protein Binding Regulation Of Hippo Signaling Transcription Elongation By RNA Polymerase II Chromosome Phosphate-containing Compound Metabolic Process Negative Regulation Of Cell Cycle Process Negative Regulation Of Signal Transduction Regulation Of Glycolytic Process DNA-templated Transcription Elongation Mesoderm Development Cytoskeleton Regulation Of Cellular Component Organization Microtubule-based Process Regulation Of Carbohydrate Catabolic Process RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity
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