SYNJ1 and CLTC

Number of citations of the paper that reports this interaction (PMID 12057195)
45

Data Source:
BioGRID (pull down)

		SYNJ1	CLTC
Gene Name		synaptojanin 1	clathrin, heavy chain (Hc)
Image
Gene Ontology Annotations	Cellular Component	Cytosol Membrane Coat	Cytoplasm Spindle Cytosol Plasma Membrane Focal Adhesion Membrane Clathrin Coat Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Clathrin-coated Vesicle Clathrin-coated Endocytic Vesicle Membrane Vesicle Trans-Golgi Network Membrane Melanosome Intracellular Membrane-bounded Organelle Protein Complex Extracellular Vesicular Exosome Clathrin Complex
	Molecular Function	Nucleotide Binding RNA Binding Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Phosphatidylinositol Phosphate 5-phosphatase Activity	Double-stranded RNA Binding Structural Molecule Activity Protein Binding Protein Kinase Binding Clathrin Light Chain Binding Poly(A) RNA Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Neurotransmitter Transport Synaptic Vesicle Priming Synaptic Vesicle Uncoating Inositol Phosphate Metabolic Process Small Molecule Metabolic Process Phosphatidylinositol Metabolic Process Inositol Phosphate Dephosphorylation Phosphatidylinositol Dephosphorylation Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Regulation Of Synaptic Vesicle Membrane Organization Positive Regulation Of Synaptic Vesicle Uncoating	Osteoblast Differentiation Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Mitotic Nuclear Division Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Receptor Internalization Transferrin Transport Membrane Organization Negative Regulation Of Hyaluronan Biosynthetic Process Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Synthesis of IP2, IP, and Ins in the cytosol Metabolism of lipids and lipoproteins Phospholipid metabolism Inositol phosphate metabolism PI Metabolism	Formation of annular gap junctions EPH-ephrin mediated repulsion of cells Axon guidance Gap junction degradation Gap junction trafficking and regulation Gap junction trafficking WNT5A-dependent internalization of FZD4 EPH-Ephrin signaling Signaling by Wnt PCP/CE pathway beta-catenin independent WNT signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		23 interactors: AMPH AP2A1 AP2M1 BIN1 CDK5 CLTA CLTC EPHB2 EPS15 FNBP4 GRB2 ITSN1 PACSIN1 PACSIN2 PACSIN3 PPP3CA SH3BP1 SH3GL1 SH3GL2 SH3GL3 SH3GLB1 SH3KBP1 SORBS2	60 interactors: AMPH AP1B1 AP1G1 AP2A2 AP2B1 AP3B1 AP3B2 ARMCX3 ARR3 ARRB1 ARRB2 C10orf88 CLINT1 CLTA CLTB DNAJC6 EHD1 EP300 EPN1 EPN2 ERG FYN GAK GGA1 GGA2 GGA3 GRIN1 GRIN2D HGS HIP1 HIP1R ITSN1 KIT LDLRAP1 MAP3K10 NCALD NDRG1 OCRL PICALM PPP1CA PPP1CC PRKACA PXN QARS SCYL2 SNX5 SNX9 SRC STAM STAMBP SYNJ1 TFAP2A TNK2 TOM1 VCL WNK1 XRCC6 YWHAG YWHAQ ZFYVE9
Entrez ID		8867	1213
HPRD ID		09182	00350
Ensembl ID		ENSG00000159082	ENSG00000141367
Uniprot IDs		B9EGN3 C9JFZ1 J3KPK1 J3KQV8 O43426 Q05CZ1	Q00610
PDB IDs		1W80 2DNR 2VJ0	2XZG 4G55
Enriched GO Terms of Interacting Partners?		Endocytosis Vesicle-mediated Transport Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Axon Guidance Cell Projection Morphogenesis Cell Part Morphogenesis Transport Neuron Projection Morphogenesis Cell-cell Signaling Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Morphogenesis Axonogenesis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Post-Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Neuron Projection Development Regulation Of Cellular Component Organization Axon Development Cell Projection Organization Membrane Organization Synaptic Transmission Cell Morphogenesis Involved In Neuron Differentiation Neurotrophin TRK Receptor Signaling Pathway Chemotaxis Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Synaptic Vesicle Transport Locomotion Neuron Development Membrane Tubulation Cell Morphogenesis Involved In Differentiation Nervous System Development Cellular Localization Movement Of Cell Or Subcellular Component Neuron Differentiation Establishment Of Localization In Cell Generation Of Neurons Regulation Of Endocytosis Neurogenesis Regulation Of Vesicle-mediated Transport Establishment Of Vesicle Localization Vesicle Localization	Vesicle-mediated Transport Endocytosis Transport Establishment Of Localization In Cell Intracellular Transport Cellular Localization Intracellular Protein Transport Cellular Protein Localization Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport ERBB Signaling Pathway Protein Transport Signaling Establishment Of Protein Localization Cell Communication Enzyme Linked Receptor Protein Signaling Pathway Protein Localization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Endocytosis Negative Regulation Of ERBB Signaling Pathway Cellular Response To Growth Factor Stimulus Regulation Of Signaling Response To Growth Factor Membrane Organization Positive Regulation Of Transport Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Stimulus Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Synaptic Transmission Endosomal Transport Negative Regulation Of Signaling Post-Golgi Vesicle-mediated Transport Signal Transduction Regulation Of Defense Response To Virus By Virus Nervous System Development Receptor-mediated Endocytosis Regulation Of Cellular Component Organization Cell-cell Signaling Response To Stimulus Positive Regulation Of Receptor-mediated Endocytosis Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Receptor Internalization Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Positive Regulation Of Endocytosis
Tagcloud ?		aberrations abundance amplified block copy druggable encodes endocytic gain gains inositol invadopodia knocking lamellipodia libraries member microrna migration neural phosphatase promoted recycling search shorter similarly synaptojanin synj2 targetable xenografts	alk clathrin contribution deregulated diffuse dlbcl dlbcls encoding feature formed lm1 lymphoma lymphomas maintenance nanomolar nod nvp otherwise providing rationale refractory repressed scid signalling subtype sustained tae684 thereby xenotransplant
Tagcloud (Difference) ?		aberrations abundance amplified block copy druggable encodes endocytic gain gains inositol invadopodia knocking lamellipodia libraries member microrna migration neural phosphatase promoted recycling search shorter similarly synaptojanin synj2 targetable xenografts	alk clathrin contribution deregulated diffuse dlbcl dlbcls encoding feature formed lm1 lymphoma lymphomas maintenance nanomolar nod nvp otherwise providing rationale refractory repressed scid signalling subtype sustained tae684 thereby xenotransplant
Tagcloud (Intersection) ?