SYNJ1 and PACSIN3

Number of citations of the paper that reports this interaction (PubMedID 11082044)
0

Data Source:
BioGRID (pull down)
HPRD (two hybrid, in vitro)

		SYNJ1	PACSIN3
Description		synaptojanin 1	protein kinase C and casein kinase substrate in neurons 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Vesicle Membrane Membrane Membrane Coat Clathrin Coat Of Coated Pit Terminal Bouton Perinuclear Region Of Cytoplasm Synaptic Membrane Presynapse	Cytoplasm Endosome Cytosol Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Nucleic Acid Binding RNA Binding Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Phosphatidylinositol Phosphate 5-phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-4-phosphate Phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Lipid Binding Calcium Channel Inhibitor Activity Identical Protein Binding
	Biological Process	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Neurotransmitter Transport Endocytosis Learning Synaptic Vesicle Priming Synaptic Vesicle Uncoating Phosphatidylinositol-3-phosphate Biosynthetic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol Dephosphorylation Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Membrane Organization Positive Regulation Of Endosome Organization	Endocytosis Cytoskeleton Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Calcium Ion Transport Plasma Membrane Tubulation
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol Clathrin-mediated endocytosis	Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Platelet reactivity in response to clopidogrel treatment ( 32472697)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Waist-to-hip ratio adjusted for body mass index ( 26785701)
Interacting Genes		30 interacting genes: AMPH AP2A1 AP2M1 BIN1 CDK5 CLTA CLTC EPHB2 EPS15 FNBP4 FOXRED1 GRB2 ITSN1 LRRK2 PACSIN1 PACSIN2 PACSIN3 PAX6 PPP3CA RASAL2 SH3BP1 SH3D19 SH3GL1 SH3GL2 SH3GL3 SH3GLB1 SH3KBP1 SH3YL1 SORBS1 SORBS2	24 interacting genes: ADAM12 ADAM15 ASAP1 ASAP2 ATXN7L2 CLNK DNM1 ITSN1 KRTAP12-2 LGALS13 OGT PACSIN1 PACSIN2 PAK2 RAF1 SMARCD1 SOS1 SOS2 SPRY2 SYNJ1 TERF2IP TNPO2 TRPV4 WASL
Entrez ID		8867	29763
HPRD ID		09182	05937
Ensembl ID		ENSG00000159082	ENSG00000165912
Uniprot IDs		A0A0D9SGJ6 B9EGN3 C9JFZ1 J3KQV8 O43426 Q05CZ1	Q9UKS6
PDB IDs		1W80 2DNR 2VJ0 7A0V
Enriched GO Terms of Interacting Partners?		Endocytosis Import Into Cell Vesicle-mediated Transport Synaptic Vesicle Endocytosis Presynaptic Endocytosis Vesicle-mediated Transport In Synapse Regulation Of Endocytosis Glutamatergic Synapse Endosome Regulation Of Vesicle-mediated Transport Postsynaptic Endocytic Zone Clathrin-dependent Endocytosis Clathrin-coated Pit Lipid Binding Establishment Of Localization In Cell Regulation Of Cellular Component Organization Receptor-mediated Endocytosis Cytosol Endolysosome Membrane Cytoskeleton Organization Clathrin-coated Endocytic Vesicle Receptor Internalization Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Plasma Membrane Postsynaptic Neurotransmitter Receptor Internalization Synapse Positive Regulation Of Endocytosis Cell Projection Morphogenesis Negative Regulation Of Transport Intracellular Protein Localization Cellular Localization AP-2 Adaptor Complex Regulation Of Transport Cytoplasmic Vesicle Membrane Organization Plasma Membrane Tubulation Regulation Of Protein Localization To Plasma Membrane Phospholipid Binding Intracellular Transport Intracellular Protein Transport Synaptic Vesicle Identical Protein Binding Clathrin Coat Assembly Cell Projection Negative Regulation Of Endocytosis Clathrin-coated Endocytic Vesicle Membrane Neuron Projection Morphogenesis Cytoskeletal Protein Binding Regulation Of Protein Localization To Cell Periphery	Negative Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Regulation Of Developmental Process Plasma Membrane Ruffle Membrane Synaptic Vesicle Endocytosis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Presynaptic Endocytosis Regulation Of Pro-B Cell Differentiation Regulation Of Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Glutamatergic Synapse Regulation Of Lymphoid Progenitor Cell Differentiation Regulation Of T Cell Differentiation Import Into Cell Insulin Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Plasma Membrane Tubulation Regulation Of Plasma Membrane Organization Cell Projection Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Lymphocyte Differentiation Vesicle-mediated Transport In Synapse Schwann Cell Development Endocytosis Protein Kinase Binding Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Protein Localization SH3 Domain Binding Regulation Of T Cell Differentiation In Thymus Establishment Of Organelle Localization Cytoplasmic Vesicle Vesicle Budding From Membrane Phosphatidylinositol-3,4,5-trisphosphate Binding Clathrin Coat Assembly Involved In Endocytosis Regulation Of Phosphorus Metabolic Process Regulation Of Immune System Process Neurotrophin Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Establishment Of Localization In Cell Regulation Of Cell Differentiation Positive Regulation Of Cellular Component Organization Regulation Of Endocytosis Regulation Of Lymphocyte Activation Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway B Cell Homeostasis Positive Regulation Of ERBB Signaling Pathway Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation
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