SYNJ1 and SORBS1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		SYNJ1	SORBS1
Description		synaptojanin 1	sorbin and SH3 domain containing 1
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Vesicle Membrane Membrane Membrane Coat Clathrin Coat Of Coated Pit Terminal Bouton Perinuclear Region Of Cytoplasm Synaptic Membrane Presynapse	Stress Fiber Nucleus Cytoplasm Centrosome Cytosol Cytoskeleton Plasma Membrane Adherens Junction Zonula Adherens Focal Adhesion Membrane Nuclear Matrix Flotillin Complex Cell-substrate Junction Membrane Raft Anchoring Junction
	Molecular Function	Nucleic Acid Binding RNA Binding Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Binding Hydrolase Activity Phosphatase Activity Phosphatidylinositol Phosphate 5-phosphatase Activity Phosphatidylinositol Phosphate 4-phosphatase Activity Phosphatidylinositol-4-phosphate Phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 5-phosphatase Activity Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Inositol-1,4,5-trisphosphate 5-phosphatase Activity	Actin Binding Insulin Receptor Binding Protein Binding Cytoskeletal Protein Binding Signaling Receptor Complex Adaptor Activity
	Biological Process	Lipid Metabolic Process Phosphatidylinositol Biosynthetic Process Neurotransmitter Transport Endocytosis Learning Synaptic Vesicle Priming Synaptic Vesicle Uncoating Phosphatidylinositol-3-phosphate Biosynthetic Process Inositol Phosphate Metabolic Process Phosphatidylinositol Metabolic Process Phosphatidylinositol Dephosphorylation Synaptic Vesicle Endocytosis Synaptic Vesicle Transport Membrane Organization Positive Regulation Of Endosome Organization	Cell-matrix Adhesion Insulin Receptor Signaling Pathway Cell-substrate Adhesion Cellular Response To Insulin Stimulus Stress Fiber Assembly Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of D-glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Focal Adhesion Assembly Positive Regulation Of Protein Localization To Plasma Membrane
Pathways		Synthesis of PIPs at the plasma membrane Synthesis of IP2, IP, and Ins in the cytosol Synthesis of IP3 and IP4 in the cytosol Clathrin-mediated endocytosis	Smooth Muscle Contraction
Drugs
Diseases
GWAS		Platelet reactivity in response to clopidogrel treatment ( 32472697)	Diabetic nephropathy in type 1 diabetes ( 25476525) Estimated glomerular filtration rate ( 31152163) Hematocrit ( 32888494) Mean platelet volume ( 32888494) Obesity-related traits ( 23251661) PR interval ( 30046033 32439900) Red blood cell count ( 32888494) Staphylococcus aureus nasal carriage (persistent) ( 26569114) Suicide risk ( 21041247)
Interacting Genes		30 interacting genes: AMPH AP2A1 AP2M1 BIN1 CDK5 CLTA CLTC EPHB2 EPS15 FNBP4 FOXRED1 GRB2 ITSN1 LRRK2 PACSIN1 PACSIN2 PACSIN3 PAX6 PPP3CA RASAL2 SH3BP1 SH3D19 SH3GL1 SH3GL2 SH3GL3 SH3GLB1 SH3KBP1 SH3YL1 SORBS1 SORBS2	31 interacting genes: ABI1 ABL1 ACTA1 ADAM15 AFDN AKT1 CBL CDK6 EFNB1 FLOT1 HUNK INPPL1 INSM1 INSR KHDRBS1 MAP4K3 PAK2 PGR PILRA PTK2 PXN RNF10 RPL4 RTN4IP1 SEMA6A SH2B2 SLC10A3 SRC SYNJ1 TENM1 VCL
Entrez ID		8867	10580
HPRD ID		09182	05587
Ensembl ID		ENSG00000159082	ENSG00000095637
Uniprot IDs		A0A0D9SGJ6 B9EGN3 C9JFZ1 J3KQV8 O43426 Q05CZ1	A0A3B3IRW8 B4DTX5 Q9BX66
PDB IDs		1W80 2DNR 2VJ0 7A0V	2DL3 2ECZ 2LJ0 2LJ1 2MOX 2O2W 2O31 2O9S 2O9V 4LN2 4LNP
Enriched GO Terms of Interacting Partners?		Endocytosis Import Into Cell Vesicle-mediated Transport Synaptic Vesicle Endocytosis Presynaptic Endocytosis Vesicle-mediated Transport In Synapse Regulation Of Endocytosis Glutamatergic Synapse Endosome Regulation Of Vesicle-mediated Transport Postsynaptic Endocytic Zone Clathrin-dependent Endocytosis Clathrin-coated Pit Lipid Binding Establishment Of Localization In Cell Regulation Of Cellular Component Organization Receptor-mediated Endocytosis Cytosol Endolysosome Membrane Cytoskeleton Organization Clathrin-coated Endocytic Vesicle Receptor Internalization Clathrin Coat Of Trans-Golgi Network Vesicle Clathrin Coat Of Coated Pit Plasma Membrane Postsynaptic Neurotransmitter Receptor Internalization Synapse Positive Regulation Of Endocytosis Cell Projection Morphogenesis Negative Regulation Of Transport Intracellular Protein Localization Cellular Localization AP-2 Adaptor Complex Regulation Of Transport Cytoplasmic Vesicle Membrane Organization Plasma Membrane Tubulation Regulation Of Protein Localization To Plasma Membrane Phospholipid Binding Intracellular Transport Intracellular Protein Transport Synaptic Vesicle Identical Protein Binding Clathrin Coat Assembly Cell Projection Negative Regulation Of Endocytosis Clathrin-coated Endocytic Vesicle Membrane Neuron Projection Morphogenesis Cytoskeletal Protein Binding Regulation Of Protein Localization To Cell Periphery	SH2 Domain Binding Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cell Adhesion Regulation Of Cell-matrix Adhesion Cell-cell Junction Regulation Of Cellular Component Organization Enzyme-linked Receptor Protein Signaling Pathway Ephrin Receptor Binding Protein Kinase Activity Immune Response-activating Cell Surface Receptor Signaling Pathway Signal Complex Assembly Cellular Response To Fluid Shear Stress Cell Surface Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Immune Response-regulating Cell Surface Receptor Signaling Pathway Focal Adhesion Regulation Of Cell Motility Kinase Activity Response To Fluid Shear Stress Lamellipodium Response To Growth Factor Regulation Of Locomotion SH3 Domain Binding Vascular Endothelial Cell Response To Fluid Shear Stress Ephrin Receptor Signaling Pathway Regulation Of Cell-substrate Adhesion Cell Migration Developmental Process Protein Autophosphorylation Immune Response-activating Signaling Pathway Protein Tyrosine Kinase Activator Activity Regulation Of Organelle Organization Regulation Of Protein Phosphorylation Regulation Of Cell Migration Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Focal Adhesion Assembly Immune Response-regulating Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Activation Of Immune Response Cell-substrate Adhesion Regulation Of Phosphorylation Immune System Process Cell Motility Regulation Of Cell-substrate Junction Organization Fc Receptor Mediated Stimulatory Signaling Pathway ERBB Signaling Pathway Regulation Of Protein Modification Process Cell-cell Contact Zone
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