KSR1 and NME1

Number of citations of the paper that reports this interaction (PubMedID 12105213)
0

Data Source:
HPRD (in vitro, in vivo)

		KSR1	NME1
Description		kinase suppressor of ras 1	NME/NM23 nucleoside diphosphate kinase 1
Image
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Ruffle Membrane Protein-containing Complex Cell Projection	Nucleus Cytoplasm Early Endosome Cytosol Membrane Ruffle Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding 14-3-3 Protein Binding Protein Serine Kinase Activity	Nucleotide Binding Magnesium Ion Binding DNA Binding RNA Binding DNA Endonuclease Activity DNA Nuclease Activity Nucleoside Diphosphate Kinase Activity Protein Histidine Kinase Activity Protein Binding ATP Binding 3'-5'-DNA Exonuclease Activity Kinase Activity Transferase Activity Phosphotransferase Activity, Phosphate Group As Acceptor GDP Binding Identical Protein Binding Ribosomal Small Subunit Binding ADP Binding Metal Ion Binding Farnesyl Diphosphate Kinase Activity Coenzyme A Binding Succinyl-CoA Binding Acetyl-CoA Binding
	Biological Process	MAPK Cascade Ras Protein Signal Transduction Regulation Of Cell Population Proliferation Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade	GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process DNA Catabolic Process Apoptotic DNA Fragmentation Isoprenoid Metabolic Process Endocytosis Nervous System Development Lactation Negative Regulation Of Cell Population Proliferation Nucleotide Metabolic Process Nucleoside Diphosphate Metabolic Process Nucleoside Triphosphate Biosynthetic Process Cell Differentiation Mammary Gland Development Protein Hexamerization Regulation Of Fatty Acid Biosynthetic Process Regulation Of Apoptotic Process ITP Biosynthetic Process Acetyl-CoA Catabolic Process Positive Regulation Of Epithelial Cell Proliferation
Pathways		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	Interconversion of nucleotide di- and triphosphates Azathioprine ADME Ribavirin ADME
Drugs			Zinc 2'-Deoxyguanosine-5'-Triphosphate Selenocysteine 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Diphosphate Adenosine Phosphonoacetic Acid Stavudine triphosphate Thymidine-5'- Diphosphate 2'-Deoxyguanosine-5'-Diphosphate 2',3'-dideoxy-3'-fluoro-urididine-5'-diphosphate Guanosine-5'-Diphosphate 3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate Zidovudine diphosphate Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Systemic lupus erythematosus ( 28714469)	Bipolar disorder ( 31043756) Conjunctival UV autofluorescence (CUVAF) ( 25590795) Metabolite levels ( 23823483)
Interacting Genes		10 interacting genes: BRAP EPHB2 ITCH MAP2K1 MAPK1 MARK3 NME1 PJA2 RAF1 YWHAZ	35 interacting genes: APEX1 AURKA CCND3 DDX19A FBXO24 FXR1 FXR2 GORASP2 ITGB1 KSR1 LNX1 MIF NIF3L1 NME3 NME4 NTAQ1 NUTF2 NXF1 PID1 POLR1C PRPF6 PRUNE1 RAC1 RORA RORB RRAD SET SMARCD1 SNCA SOX30 SREK1IP1 TERF1 TIAM1 TNPO2 TNPO3
Entrez ID		8844	4830
HPRD ID		18980	01131
Ensembl ID		ENSG00000141068	ENSG00000239672
Uniprot IDs		A0A2R8Y5H9 Q8IVT5	A0A384MTW7 P15531
PDB IDs		5VYK 7JUW 7JUX 7JUY 7JUZ 7JV0 7JV1 9AXH	1JXV 1UCN 2HVD 2HVE 3L7U 4ENO 5UI4 8OOV
Enriched GO Terms of Interacting Partners?		Transferase Activity Regulation Of MAPK Cascade ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway MAPK Cascade Schwann Cell Development Protein Modification Process Face Development ERBB2 Signaling Pathway Kinase Activity Thyroid Gland Development Protein Phosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Golgi Inheritance Negative Regulation Of Signal Transduction Thymus Development Negative Regulation Of Signaling Negative Regulation Of Cell Communication ERK1 And ERK2 Cascade Regulation Of Cell Communication Regulation Of Signaling Protein Kinase Activity Glial Cell Development Trachea Formation ERBB Signaling Pathway Intracellular Signal Transduction Gland Development Bergmann Glial Cell Differentiation Myelination Axon Ensheathment Hematopoietic Or Lymphoid Organ Development Protein Metabolic Process Early Endosome Protein Serine Kinase Activity Negative Regulation Of Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Regulation Of Golgi Organization Pseudopodium ATP Binding Regulation Of Early Endosome To Late Endosome Transport Type B Pancreatic Cell Proliferation Regulation Of Defense Response Protein Serine/threonine Kinase Activity Intracellular Signaling Cassette Animal Organ Formation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Macromolecule Metabolic Process	Mitochondrion-mitochondrion Outer Membrane Tether Activity Regulation Of Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission MRNA Transport RNA Transport Nuclear Import Signal Receptor Activity Regulation Of Long-term Neuronal Synaptic Plasticity Cytoplasmic Stress Granule Cytoplasm Nucleobase-containing Compound Transport Negative Regulation Of Biosynthetic Process Postsynapse Double-stranded Telomeric DNA Binding Cellular Component Assembly UTP Biosynthetic Process GTP Biosynthetic Process UTP Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Nuclear Transport Nucleocytoplasmic Transport Regulation Of Cell Differentiation Central Nervous System Neuron Differentiation Protein Hexamerization Protein Binding Regulation Of Cell Development Regulation Of Macrophage Activation Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Development CTP Biosynthetic Process CTP Metabolic Process Regulation Of Microtubule Polymerization Protein-containing Complex Organization Nucleoside Diphosphate Kinase Activity Regulation Of Hydrogen Peroxide Metabolic Process Nucleus Translation Regulator Activity Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Cytoplasmic Ribonucleoprotein Granule Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Neurotransmitter Uptake Neuron Differentiation Protein-containing Complex Assembly Regulation Of Synaptic Plasticity Nucleosome Disassembly Regulation Of Rho Protein Signal Transduction Regulation Of Neurogenesis GTP Metabolic Process Regulation Of Cell Maturation Protein-DNA Complex Disassembly
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