KSR1 and PJA2

Number of citations of the paper that reports this interaction (PubMedID 27195677)
50

Data Source:
BioGRID (enzymatic study)

		KSR1	PJA2
Description		kinase suppressor of ras 1	praja ring finger ubiquitin ligase 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Membrane Ruffle Membrane Protein-containing Complex Cell Projection	Golgi Membrane Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Cytoskeleton Plasma Membrane Postsynaptic Density Membrane Centriolar Satellite Ciliary Basal Body Synapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding Zinc Ion Binding Kinase Activity Transferase Activity Metal Ion Binding 14-3-3 Protein Binding Protein Serine Kinase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	MAPK Cascade Ras Protein Signal Transduction Regulation Of Cell Population Proliferation Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade	Inflammatory Response Long-term Memory Regulation Of Protein Kinase A Signaling Protein Ubiquitination Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Regulation Of Macrophage Activation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Positive Regulation Of JNK Cascade Positive Regulation Of P38MAPK Cascade
Pathways		RAF activation MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants Signaling by RAF1 mutants	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Systemic lupus erythematosus ( 28714469)	Apolipoprotein A1 levels ( 32203549) Body mass index ( 29273807) Frontotemporal dementia with GRN mutation ( 29724592) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Triglyceride levels ( 34074324)
Interacting Genes		10 interacting genes: BRAP EPHB2 ITCH MAP2K1 MAPK1 MARK3 NME1 PJA2 RAF1 YWHAZ	16 interacting genes: BBS2 KSR1 KSR2 MAGED1 MFHAS1 PRKAR1A PRKAR2A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2J1 UBE2L6 UBE2N UBE2W WEE2-AS1
Entrez ID		8844	9867
HPRD ID		18980	11436
Ensembl ID		ENSG00000141068	ENSG00000198961
Uniprot IDs		A0A2R8Y5H9 Q8IVT5	O43164
PDB IDs		5VYK 7JUW 7JUX 7JUY 7JUZ 7JV0 7JV1 9AXH
Enriched GO Terms of Interacting Partners?		Transferase Activity Regulation Of MAPK Cascade ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway MAPK Cascade Schwann Cell Development Protein Modification Process Face Development ERBB2 Signaling Pathway Kinase Activity Thyroid Gland Development Protein Phosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Golgi Inheritance Negative Regulation Of Signal Transduction Thymus Development Negative Regulation Of Signaling Negative Regulation Of Cell Communication ERK1 And ERK2 Cascade Regulation Of Cell Communication Regulation Of Signaling Protein Kinase Activity Glial Cell Development Trachea Formation ERBB Signaling Pathway Intracellular Signal Transduction Gland Development Bergmann Glial Cell Differentiation Myelination Axon Ensheathment Hematopoietic Or Lymphoid Organ Development Protein Metabolic Process Early Endosome Protein Serine Kinase Activity Negative Regulation Of Intracellular Signal Transduction Phosphate-containing Compound Metabolic Process Regulation Of Golgi Organization Pseudopodium ATP Binding Regulation Of Early Endosome To Late Endosome Transport Type B Pancreatic Cell Proliferation Regulation Of Defense Response Protein Serine/threonine Kinase Activity Intracellular Signaling Cassette Animal Organ Formation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Macromolecule Metabolic Process	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Binding Post-translational Protein Modification Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Transferase Activity ATP Binding Macromolecule Catabolic Process Protein K48-linked Ubiquitination Protein-containing Complex Proteolysis Protein K11-linked Ubiquitination CAMP-dependent Protein Kinase Regulator Activity Protein Monoubiquitination TORC1 Signaling Negative Regulation Of TORC1 Signaling CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Inhibitor Activity Protein Modification Process Nucleotide-activated Protein Kinase Complex Proteasomal Protein Catabolic Process MAP-kinase Scaffold Activity TOR Signaling Protein Kinase A Catalytic Subunit Binding Negative Regulation Of TOR Signaling Regulation Of Signal Transduction Intracellular Signal Transduction Regulation Of TORC1 Signaling Positive Regulation Of Protein Polyubiquitination Catabolic Process Negative Regulation Of Signal Transduction CAMP Binding Regulation Of Intracellular Signal Transduction Protein Catabolic Process Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of CAMP/PKA Signal Transduction Protein K6-linked Ubiquitination Regulation Of Protein Polyubiquitination Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Plasma Membrane Raft
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