KSR1 and EPHB2

Number of citations of the paper that reports this interaction (PMID 11940661)
70

Data Source:
HPRD (in vivo)

		KSR1	EPHB2
Gene Name		kinase suppressor of ras 1	EPH receptor B2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane Axon Dendrite Neuronal Cell Body
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Kinase Binding Metal Ion Binding	Protein Tyrosine Kinase Activity Transmembrane-ephrin Receptor Activity Receptor Binding Protein Binding ATP Binding Axon Guidance Receptor Activity
	Biological Process	Protein Phosphorylation Ras Protein Signal Transduction Positive Regulation Of MAPK Cascade	Angiogenesis Urogenital System Development Nervous System Development Axon Guidance Axonal Fasciculation Learning Phosphorylation Peptidyl-tyrosine Phosphorylation Optic Nerve Morphogenesis Central Nervous System Projection Neuron Axonogenesis Corpus Callosum Development Retinal Ganglion Cell Axon Guidance Inner Ear Morphogenesis Ephrin Receptor Signaling Pathway Positive Regulation Of Long-term Neuronal Synaptic Plasticity Camera-type Eye Morphogenesis Negative Regulation Of Axonogenesis Regulation Of Body Fluid Levels Positive Regulation Of Synapse Assembly Palate Development Dendritic Spine Development Dendritic Spine Morphogenesis Commissural Neuron Axon Guidance
Pathways			EPHB-mediated forward signaling Ephrin signaling EPH-ephrin mediated repulsion of cells Axon guidance EPH-Ephrin signaling L1CAM interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: EPHB2 MAP2K1 MAPK1 MARK3 NME1 RAF1 YWHAZ	36 interactors: ABL1 ABL2 ACP1 AQP1 ARHGEF6 BCL2 CRK EFNA5 EFNB1 EFNB2 ERF FOS GRB2 GRIN1 GRIN2B ITSN1 KALRN KSR1 MLLT4 MMP2 MMP9 NCK1 PICK1 PLCG1 PTK2 RASA1 RRAS RYK SDC2 SDCBP SH2D3C SRC SYNJ1 VAV2 VEGFA YES1
Entrez ID		8844	2048
HPRD ID		18980	02997
Ensembl ID			ENSG00000133216
Uniprot IDs		H7BYU0 Q8IVT5	P29323
PDB IDs			1B4F 1F0M 2QBX
Enriched GO Terms of Interacting Partners?		Phosphorylation Regulation Of Golgi Inheritance Phosphate-containing Compound Metabolic Process Activation Of MAPKK Activity Regulation Of Golgi Organization Golgi Inheritance Axon Guidance Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport Axonogenesis Insulin Receptor Signaling Pathway Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Axon Development Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cellular Response To Fibroblast Growth Factor Stimulus Neuron Projection Morphogenesis Platelet Activation Response To Fibroblast Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Wounding Ras Protein Signal Transduction Cell Morphogenesis Involved In Differentiation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway MAPK Cascade Neuron Projection Development Fc Receptor Signaling Pathway Activation Of Protein Kinase Activity Cell Projection Morphogenesis Placenta Blood Vessel Development Signal Transduction By Phosphorylation Cell Part Morphogenesis Cardiovascular System Development Response To Insulin Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Component Organization Cellular Response To Peptide Hormone Stimulus Neuron Development Cellular Response To Peptide Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Labyrinthine Layer Development Toll-like Receptor TLR6:TLR2 Signaling Pathway	Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Ephrin Receptor Signaling Pathway Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Chemotaxis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Development Neuron Development Cell Projection Morphogenesis Cell Projection Organization Cell Part Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Neuron Differentiation Cell Morphogenesis Response To External Stimulus Generation Of Neurons Cell Development Neurogenesis Locomotion Nervous System Development Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Signaling Cell Communication Cell Differentiation Cell Surface Receptor Signaling Pathway Signal Transduction Regulation Of Intracellular Signal Transduction System Development Regulation Of Signaling Cellular Response To Stimulus Anatomical Structure Development Multicellular Organismal Development Developmental Process Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Metabolic Process Response To Stimulus Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Phagocytosis Immune Response-regulating Cell Surface Receptor Signaling Pathway Fc Receptor Signaling Pathway Cell Migration Regulation Of Phosphorus Metabolic Process
Tagcloud ?		actors advance bc deregulation dfs disequilibrium doi eralpha igfr implication journal kinome lmtk3 multivariable october online pharmacogenomics publication rs1075952 rs224190 rs2241906 rs2293180 suppressors tam tc tpj tt undergone utr	10a1 10ca1a 3d array beta3 emt ephrin impede inhibits integrin interplay intricate invasion mcf mesenchymal metallo migration mmp9 modulated nmumg nutlin p53 proteinase spheroid tgf transforming transwell verification whereby
Tagcloud (Difference) ?		actors advance bc deregulation dfs disequilibrium doi eralpha igfr implication journal kinome lmtk3 multivariable october online pharmacogenomics publication rs1075952 rs224190 rs2241906 rs2293180 suppressors tam tc tpj tt undergone utr	10a1 10ca1a 3d array beta3 emt ephrin impede inhibits integrin interplay intricate invasion mcf mesenchymal metallo migration mmp9 modulated nmumg nutlin p53 proteinase spheroid tgf transforming transwell verification whereby
Tagcloud (Intersection) ?