KSR1 and MARK3

Number of citations of the paper that reports this interaction (PMID 11741534)
75

Data Source:
HPRD (in vivo)

		KSR1	MARK3
Gene Name		kinase suppressor of ras 1	MAP/microtubule affinity-regulating kinase 3
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP-kinase Scaffold Activity Protein Binding ATP Binding Mitogen-activated Protein Kinase Kinase Binding Metal Ion Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Protein Phosphorylation Ras Protein Signal Transduction Positive Regulation Of MAPK Cascade	Protein Phosphorylation
Pathways
Drugs
Diseases
GWAS			Bone mineral density ( 22504420)
Protein-Protein Interactions		7 interactors: EPHB2 MAP2K1 MAPK1 MARK3 NME1 RAF1 YWHAZ	27 interactors: ANKRD7 ASB13 ATP6V0C CDC25C CHGB CPSF4 DYNLL1 FANCF HDAC7 KSR1 MAP2 MAPT MITF NOL11 PIM1 PKP2 PMPCB PNPLA2 PRKCQ SAAL1 SFN TCEA2 TTR VPS11 YWHAG YWHAQ YWHAZ
Entrez ID		8844	4140
HPRD ID		18980	04058
Ensembl ID			ENSG00000075413
Uniprot IDs		H7BYU0 Q8IVT5	P27448 Q86U11
PDB IDs			2QNJ 3FE3
Enriched GO Terms of Interacting Partners?		Phosphorylation Regulation Of Golgi Inheritance Phosphate-containing Compound Metabolic Process Activation Of MAPKK Activity Regulation Of Golgi Organization Golgi Inheritance Axon Guidance Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Early Endosome To Late Endosome Transport Axonogenesis Insulin Receptor Signaling Pathway Protein Phosphorylation Epidermal Growth Factor Receptor Signaling Pathway Axon Development Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Body Fluid Levels Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Cellular Response To Fibroblast Growth Factor Stimulus Neuron Projection Morphogenesis Platelet Activation Response To Fibroblast Growth Factor Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Insulin Stimulus Response To Wounding Ras Protein Signal Transduction Cell Morphogenesis Involved In Differentiation Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway MAPK Cascade Neuron Projection Development Fc Receptor Signaling Pathway Activation Of Protein Kinase Activity Cell Projection Morphogenesis Placenta Blood Vessel Development Signal Transduction By Phosphorylation Cell Part Morphogenesis Cardiovascular System Development Response To Insulin Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Component Organization Cellular Response To Peptide Hormone Stimulus Neuron Development Cellular Response To Peptide Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Labyrinthine Layer Development Toll-like Receptor TLR6:TLR2 Signaling Pathway	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Organelle Organization Apoptotic Process Positive Regulation Of Intracellular Transport Regulation Of Intracellular Transport Programmed Cell Death Cell Death Death Organelle Organization Apoptotic Signaling Pathway Regulation Of Organelle Organization Regulation Of Apoptotic Process Positive Regulation Of Transport Regulation Of Cellular Component Organization Regulation Of Cell Death Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Signal Transduction G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Apoptotic Process Multicellular Organismal Development Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death System Development Intracellular Signal Transduction Regulation Of Cellular Localization Regulation Of Establishment Of Protein Localization Substantia Nigra Development Protein Targeting Regulation Of Protein Localization Developmental Process Cellular Response To Insulin Stimulus Neural Nucleus Development Signaling Anatomical Structure Development Regulation Of Phosphorylation Protein Targeting To Mitochondrion Regulation Of Cellular Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Intracellular Protein Transport Cell Communication Negative Regulation Of Apoptotic Process Positive Regulation Of T-helper 2 Cell Activation
Tagcloud ?		actors advance bc deregulation dfs disequilibrium doi eralpha igfr implication journal kinome lmtk3 multivariable october online pharmacogenomics publication rs1075952 rs224190 rs2241906 rs2293180 suppressors tam tc tpj tt undergone utr	acrylamide amiloride bbmv benzoyl border brush cariporide dihydro guanidine guanidino hnhe1 ic50 isopro isopropyl lap1 methane methylsulphonyl micromol nhe nhe1 nhe2 nhe3 ok opossum propenyl pylidene rbnhe2 s3226 sulphonate
Tagcloud (Difference) ?		actors advance bc deregulation dfs disequilibrium doi eralpha igfr implication journal kinome lmtk3 multivariable october online pharmacogenomics publication rs1075952 rs224190 rs2241906 rs2293180 suppressors tam tc tpj tt undergone utr	acrylamide amiloride bbmv benzoyl border brush cariporide dihydro guanidine guanidino hnhe1 ic50 isopro isopropyl lap1 methane methylsulphonyl micromol nhe nhe1 nhe2 nhe3 ok opossum propenyl pylidene rbnhe2 s3226 sulphonate
Tagcloud (Intersection) ?