NUMBL and RIPK1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		NUMBL	RIPK1
Name		NUMB like endocytic adaptor protein	receptor interacting serine/threonine kinase 1
Structure
GO Annotations	Cellular Component	Cytoplasm Glutamatergic Synapse	Cytoplasm Mitochondrion Cytosol Plasma Membrane Endosome Membrane Membrane Death-inducing Signaling Complex Protein-containing Complex Receptor Complex Ripoptosome
	Molecular Function	Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity Death Receptor Binding Protein Binding ATP Binding Kinase Activity Transferase Activity Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Death Domain Binding Protein Serine Kinase Activity
	Biological Process	Nervous System Development Neuroblast Proliferation Axonogenesis Cytokine-mediated Signaling Pathway Protein Metabolic Process Lateral Ventricle Development Neuroblast Division In Subventricular Zone Forebrain Development Adherens Junction Organization Positive Regulation Of Neurogenesis Positive Regulation Of Dendrite Morphogenesis Regulation Of Postsynapse Assembly	MAPK Cascade Positive Regulation Of Protein Phosphorylation Apoptotic Process Inflammatory Response Response To Oxidative Stress Signal Transduction Canonical NF-kappaB Signal Transduction Positive Regulation Of Gene Expression Programmed Cell Death Protein Catabolic Process Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Tumor Necrosis Factor-mediated Signaling Pathway Response To Tumor Necrosis Factor Intracellular Signal Transduction Peptidyl-serine Autophosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Protein Autophosphorylation Positive Regulation Of Inflammatory Response Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Necroptotic Process Positive Regulation Of Necroptotic Process Negative Regulation Of Necroptotic Process Positive Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Interleukin-6-mediated Signaling Pathway T Cell Apoptotic Process Necroptotic Process Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Programmed Necrotic Cell Death Ripoptosome Assembly Necroptotic Signaling Pathway Positive Regulation Of Execution Phase Of Apoptosis Ripoptosome Assembly Involved In Necroptotic Process Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of MiRNA Processing Amyloid Fibril Formation Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		None	Caspase activation via Death Receptors in the presence of ligand TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TRP channels Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Regulation of necroptotic cell death Ub-specific processing proteases Ovarian tumor domain proteases Dimerization of procaspase-8 TNF signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IKK complex recruitment mediated by RIP1 Potential therapeutics for SARS Microbial modulation of RIPK1-mediated regulated necrosis SARS-CoV-1-mediated effects on programmed cell death Defective RIPK1-mediated regulated necrosis
Drugs		None	Fostamatinib
GWAS		Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) level) ( 27702941 ) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941 ) Caffeine metabolism (plasma 3,7-dimethylxanthine (theobromine) level) ( 27702941 ) Carotid intima media thickness (mean) ( 31801372 ) Kawasaki disease ( 22446962 ) Lung adenocarcinoma ( 28604730 ) Lung cancer ( 28604730 ) tricyclic pyrone compound response (IC50) ( 33610756 )	Cerebral white matter volume ( 31530798 ) Idiopathic osteonecrosis of the femoral head ( 28000841 )
Novel Interactors		None recorded	8 novel interactors: GMPR H2BC13 MAP3K1 PDXK PRP4K PXDC1 WRNIP1 ZNHIT1
Interacting Genes		24 interacting genes: ACTN1 APP ATXN1 BHLHE40 EGFR EPS15 ESRP2 GAA GPATCH8 GRIP1 MAGED1 NOTCH1 PSMA3 RBFOX1 RIPK1 SIAH1 SPSB3 TAB2 THPO TMC5 TRAF5 TRAF6 UBE3A YWHAG	49 interacting genes: ANKRD13A CASP8 CCDC50 CDC42BPB CFLAR CRADD CTNNB1 EGFR FADD FAS HSP90AA1 IKBKE IKBKG ITCH MAP3K14 MAP3K3 MAP3K8 MTDH NFKB1 NUMBL OTUD1 PPDPF PTK2 RIPK3 RNF11 RNF216 RPA1 SQSTM1 TAX1BP1 TBK1 TICAM1 TNF TNFAIP3 TNFRSF10A TNFRSF10B TNFRSF1A TRADD TRAF1 TRAF2 TRAF3 TRAF5 TRAF6 TRIM38 TRIM72 TRPC4AP UBE2N USP21 YOD1 ZFAND5
Entrez ID		9253	8737
HPRD ID		04931	04583
Ensembl ID		ENSG00000105245	ENSG00000137275
Uniprot IDs		A0A0C4DGH3 A8K033 B7Z5W0 Q9Y6R0	Q13546
PDB IDs		3F0W	4ITH 4ITI 4ITJ 4NEU 5HX6 5TX5 5V7Z 6AC5 6C3E 6C4D 6HHO 6NW2 6NYH 6OCQ 6R5F 6RLN 7CJB 7FCZ 7FD0 7XMK 7YDX 8I2N
GO Terms Enriched among Interactors		Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Interleukin-17-mediated Signaling Pathway Positive Regulation Of Signal Transduction Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Phosphate Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Amyloid Fibril Formation Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Protein Phosphorylation Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Phosphorylation Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Regulation Of Developmental Process Positive Regulation Of MAPK Cascade Regulation Of Cell Population Proliferation Protein Polyubiquitination Positive Regulation Of Metabolic Process Regulation Of Cell Communication Endosome Membrane Positive Regulation Of Apoptotic Signaling Pathway Macromolecule Catabolic Process Regulation Of Apoptotic Process Canonical NF-kappaB Signal Transduction Cytosol Tumor Necrosis Factor-mediated Signaling Pathway CD40 Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process CD40 Receptor Complex Regulation Of Primary Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Receptor Complex Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Signaling Adaptor Activity Positive Regulation Of Cell Population Proliferation	Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Cell Death Programmed Cell Death Tumor Necrosis Factor-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Signal Transduction Regulation Of Programmed Cell Death Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Cellular Response To Mechanical Stimulus Tumor Necrosis Factor Receptor Binding Positive Regulation Of Defense Response Response To Mechanical Stimulus Non-canonical NF-kappaB Signal Transduction Signaling Adaptor Activity Apoptotic Signaling Pathway Signal Transduction Ubiquitin Protein Ligase Binding Regulation Of Signal Transduction Intracellular Signal Transduction Activation Of Immune Response Extrinsic Apoptotic Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Death-inducing Signaling Complex Regulation Of Defense Response Regulation Of Immune Response Response To Virus Positive Regulation Of Immune Response Immune System Process TRAIL-activated Apoptotic Signaling Pathway Cytokine-mediated Signaling Pathway Immune Response-regulating Signaling Pathway Response To External Biotic Stimulus Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Activation Of Innate Immune Response Regulation Of Cell Communication Defense Response Immune Response-activating Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Response To Other Organism Positive Regulation Of Innate Immune Response Positive Regulation Of Immune System Process Regulation Of Immune System Process