NUMBL and TMC5

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		NUMBL	TMC5
Description		NUMB like endocytic adaptor protein	transmembrane channel like 5
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Glutamatergic Synapse	Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Mechanosensitive Monoatomic Ion Channel Activity
	Biological Process	Nervous System Development Neuroblast Proliferation Axonogenesis Cytokine-mediated Signaling Pathway Protein Metabolic Process Lateral Ventricle Development Neuroblast Division In Subventricular Zone Forebrain Development Adherens Junction Organization Positive Regulation Of Neurogenesis Positive Regulation Of Dendrite Morphogenesis Regulation Of Postsynapse Assembly	Monoatomic Ion Transmembrane Transport
Pathways
Drugs
Diseases
GWAS		Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Caffeine metabolism (plasma 3,7-dimethylxanthine (theobromine) level) ( 27702941) Carotid intima media thickness (mean) ( 31801372) Kawasaki disease ( 22446962) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) tricyclic pyrone compound response (IC50) ( 33610756)	Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol ( 31170924) Nicotine dependence symptom count ( 25555482) Parkinson's disease motor subtype (tremor dominant vs postural instability/gait difficulty) ( 33987465) Sleep duration ( 23728906)
Interacting Genes		24 interacting genes: ACTN1 APP ATXN1 BHLHE40 EGFR EPS15 ESRP2 GAA GPATCH8 GRIP1 MAGED1 NOTCH1 PSMA3 RBFOX1 RIPK1 SIAH1 SPSB3 TAB2 THPO TMC5 TRAF5 TRAF6 UBE3A YWHAG	1 interacting genes: NUMBL
Entrez ID		9253	79838
HPRD ID		04931	15516
Ensembl ID		ENSG00000105245	ENSG00000103534
Uniprot IDs		A0A0C4DGH3 A8K033 B7Z5W0 Q9Y6R0	B7Z5K3 B7Z946 F5GYU8 Q6UXY8
PDB IDs		3F0W
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Interleukin-17-mediated Signaling Pathway Positive Regulation Of Signal Transduction Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Phosphate Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Amyloid Fibril Formation Regulation Of Signaling Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Positive Regulation Of Protein Phosphorylation Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Phosphorylation Regulation Of Cell Differentiation Positive Regulation Of Phosphorylation Regulation Of Developmental Process Positive Regulation Of MAPK Cascade Regulation Of Cell Population Proliferation Protein Polyubiquitination Positive Regulation Of Metabolic Process Regulation Of Cell Communication Endosome Membrane Positive Regulation Of Apoptotic Signaling Pathway Macromolecule Catabolic Process Regulation Of Apoptotic Process Canonical NF-kappaB Signal Transduction Cytosol Tumor Necrosis Factor-mediated Signaling Pathway CD40 Signaling Pathway Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process CD40 Receptor Complex Regulation Of Primary Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Receptor Complex Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Signaling Adaptor Activity Positive Regulation Of Cell Population Proliferation	Neuroblast Division In Subventricular Zone Lateral Ventricle Development Regulation Of Postsynapse Assembly Neuroblast Proliferation Positive Regulation Of Dendrite Morphogenesis Adherens Junction Organization Regulation Of Dendrite Morphogenesis Forebrain Development Neural Precursor Cell Proliferation Regulation Of Dendrite Development Regulation Of Postsynapse Organization Axonogenesis Regulation Of Synapse Assembly Cell-cell Junction Organization
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