SNAI1 and NBN

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		SNAI1	NBN
Description		snail family transcriptional repressor 1	nibrin
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Pericentric Heterochromatin Cytoplasm Cytosol	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Chromosome Nucleolus Golgi Apparatus Cytosol PML Body Mre11 Complex Site Of Double-strand Break Nuclear Inclusion Body BRCA1-C Complex Chromosomal Region
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Kinase Binding Sequence-specific DNA Binding Metal Ion Binding E-box Binding Sequence-specific Double-stranded DNA Binding	Damaged DNA Binding Protein Binding Histone Binding Protein Serine/threonine Kinase Activator Activity Phosphorylation-dependent Protein Binding DNA-binding Transcription Factor Binding Chromatin-protein Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Mesoderm Formation Epithelial To Mesenchymal Transition Aortic Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Mesoderm Development Epithelial Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Cell Migration Hair Follicle Morphogenesis Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Mesenchymal Cell Differentiation Roof Of Mouth Development Canonical Wnt Signaling Pathway Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Left/right Pattern Formation Heterochromatin Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Bicellular Tight Junction Assembly	DNA Damage Checkpoint Signaling Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing In Utero Embryonic Development Blastocyst Growth DNA Repair Double-strand Break Repair DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Neuroblast Proliferation Regulation Of DNA-templated DNA Replication Initiation DNA Damage Response, Signal Transduction By P53 Class Mediator Protection From Non-homologous End Joining At Telomere Telomeric 3' Overhang Formation Positive Regulation Of Telomere Maintenance Homologous Recombination Telomere Maintenance In Response To DNA Damage Mitotic G2/M Transition Checkpoint Isotype Switching Neuromuscular Process Controlling Balance Meiotic Cell Cycle Regulation Of Cell Cycle R-loop Processing Protein K63-linked Ubiquitination T-circle Formation Telomere Maintenance Via Telomere Trimming Intrinsic Apoptotic Signaling Pathway Double-strand Break Repair Via Alternative Nonhomologous End Joining DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of Telomere Capping Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break Positive Regulation Of Double-strand Break Repair
Pathways		Regulation of PTEN gene transcription Regulation of PTEN gene transcription Epithelial-Mesenchymal Transition (EMT) during gastrulation Regulation of CDH11 gene transcription Negative Regulation of CDH1 Gene Transcription	DNA Damage/Telomere Stress Induced Senescence HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination Defective homologous recombination repair (HRR) due to BRCA1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function Impaired BRCA2 binding to RAD51 Impaired BRCA2 binding to PALB2
Drugs
Diseases			DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS		Psoriasis ( 20953189)	Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494)
Interacting Genes		49 interacting genes: ACTN2 ACTN3 BRMS1 COG6 CREBBP CTDSP1 CTDSP2 CTDSPL DDB1 EFHC1 EIF3H EXOSC8 FBXO22 FBXO45 FHL2 GLMN GOLGA6L9 GSK3B HOXD4 KPNB1 KRT31 KRT40 KRTAP1-1 KRTAP10-3 LATS2 LSP1 MFHAS1 MID2 MTA1 MTUS2 NBN NOTCH1 NOTCH2NLA OTUB1 PALB2 PAX2 PFDN5 PPIL2 PTEN PTPN1 RBX1 RCOR1 TGFB1 TNFAIP3 TRAF2 TRIM23 TRIP6 USP29 XRCC3	35 interacting genes: ATF2 ATM ATR BAP1 BRCA1 CASC3 CCNE1 CDK9 CHEK2 DCLRE1C EP300 FANCD2 H2AX H3-4 HIF1A MDC1 MRE11 NABP2 NAT2 NCL PRKDC RAD50 RAD51 RECQL5 SIRT1 SNAI1 SUMO2 TERF1 TLK1 TREX1 UBE2D1 UBE2N VRK1 XRCC4 XRCC5
Entrez ID		6615	4683
HPRD ID		05025	04050
Ensembl ID		ENSG00000124216	ENSG00000104320
Uniprot IDs		O95863	A0A0C4DG07 O60934
PDB IDs		2Y48 3W5K 3ZMT 4QLI 8BOX 8F59 8FDV 8FJ7	5WQD 7SID 8BAH
Enriched GO Terms of Interacting Partners?		Protein Modification Process Positive Regulation Of Signal Transduction Post-translational Protein Modification Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein K48-linked Deubiquitination RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Protein Metabolic Process Regulation Of Mitotic Cell Cycle Enzyme Binding Regulation Of Primary Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Phosphatase Activity Positive Regulation Of Catabolic Process Cellular Response To Stress Regulation Of Intracellular Signal Transduction Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Process Protein Ubiquitination Cul4A-RING E3 Ubiquitin Ligase Complex Protein Catabolic Process Telomere Maintenance Via Telomere Trimming Negative Regulation Of Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Macromolecule Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Mesenchymal Cell Differentiation Protein Polyubiquitination Response To Stress Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Autoubiquitination Negative Regulation Of Signal Transduction Negative Regulation Of Calcium-mediated Signaling Regulation Of Cell Cycle Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Phosphoprotein Phosphatase Activity Cytoplasm Negative Regulation Of Cell Communication	DNA Damage Response DNA Metabolic Process DNA Repair Double-strand Break Repair Response To Ionizing Radiation Nucleoplasm Cellular Response To Stress Negative Regulation Of Cell Cycle Process DNA Recombination Chromosome, Telomeric Region DNA Damage Checkpoint Signaling Response To Radiation Negative Regulation Of Cell Cycle Nucleic Acid Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of DNA Metabolic Process Regulation Of DNA Repair Regulation Of Cellular Response To Stress Regulation Of Cell Cycle Phase Transition Recombinational Repair Regulation Of Double-strand Break Repair Telomere Maintenance Negative Regulation Of Mitotic Cell Cycle Signal Transduction In Response To DNA Damage Regulation Of Cell Cycle Process Mitotic DNA Damage Checkpoint Signaling Regulation Of Cell Cycle Mitotic DNA Integrity Checkpoint Signaling Regulation Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Telomere Organization Chromosome Nucleobase-containing Compound Metabolic Process Chromatin Organization Double-strand Break Repair Via Homologous Recombination Response To Gamma Radiation Macromolecule Metabolic Process Positive Regulation Of DNA Metabolic Process Site Of Double-strand Break Cellular Response To Ionizing Radiation Positive Regulation Of DNA Repair Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromosome Organization Involved In Meiotic Cell Cycle Chromatin Remodeling Cellular Response To Gamma Radiation Positive Regulation Of Double-strand Break Repair DNA Binding Regulation Of Primary Metabolic Process
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