SNAI1 and LSP1

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		SNAI1	LSP1
Description		snail family transcriptional repressor 1	lymphocyte specific protein 1
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Pericentric Heterochromatin Cytoplasm Cytosol	Plasma Membrane Actin Cytoskeleton Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Kinase Binding Sequence-specific DNA Binding Metal Ion Binding E-box Binding Sequence-specific Double-stranded DNA Binding	Actin Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Mesoderm Formation Epithelial To Mesenchymal Transition Aortic Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Mesoderm Development Epithelial Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Cell Migration Hair Follicle Morphogenesis Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Mesenchymal Cell Differentiation Roof Of Mouth Development Canonical Wnt Signaling Pathway Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Left/right Pattern Formation Heterochromatin Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Bicellular Tight Junction Assembly	Chemotaxis Defense Response Cellular Defense Response Signal Transduction Cellular Response To Interleukin-7
Pathways		Regulation of PTEN gene transcription Regulation of PTEN gene transcription Epithelial-Mesenchymal Transition (EMT) during gastrulation Regulation of CDH11 gene transcription Negative Regulation of CDH1 Gene Transcription
Drugs
Diseases
GWAS		Psoriasis ( 20953189)	Bladder cancer ( 24163127) Breast cancer ( 20453838 17529967 23535729 29059683 27117709) Breast cancer (estrogen-receptor negative) ( 27117709) Celiac disease ( 23936387) Central corneal thickness ( 32528159) Diastolic blood pressure ( 30487518 27618452 27841878) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Granulocyte percentage of myeloid white cells ( 27863252) Hypertension ( 30487518) Inflammatory bowel disease ( 28067908 23128233) Lymphocyte count ( 32888494) Mammographic density (dense area) ( 25342443) Mean arterial pressure ( 29403010 30487518) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (antihypertensives) ( 31015401) Medication use (beta blocking agents) ( 31015401) Methadone dose in opioid dependence ( 28115739) Milk allergy ( 25710614) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Potassium levels ( 29403010) Pulse pressure ( 30578418 27841878) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 27618452 29403010 30487518 30578418 27841878) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Ulcerative colitis ( 28067908 21297633)
Interacting Genes		49 interacting genes: ACTN2 ACTN3 BRMS1 COG6 CREBBP CTDSP1 CTDSP2 CTDSPL DDB1 EFHC1 EIF3H EXOSC8 FBXO22 FBXO45 FHL2 GLMN GOLGA6L9 GSK3B HOXD4 KPNB1 KRT31 KRT40 KRTAP1-1 KRTAP10-3 LATS2 LSP1 MFHAS1 MID2 MTA1 MTUS2 NBN NOTCH1 NOTCH2NLA OTUB1 PALB2 PAX2 PFDN5 PPIL2 PTEN PTPN1 RBX1 RCOR1 TGFB1 TNFAIP3 TRAF2 TRIM23 TRIP6 USP29 XRCC3	11 interacting genes: ACTG1 BMPR2 CFTR GREB1 IL24 KLK6 LYPD3 MAPKAPK2 SCGB2A2 SNAI1 THRSP
Entrez ID		6615	4046
HPRD ID		05025	01083
Ensembl ID		ENSG00000124216	ENSG00000130592
Uniprot IDs		O95863	A8K7L8 P33241
PDB IDs		2Y48 3W5K 3ZMT 4QLI 8BOX 8F59 8FDV 8FJ7	3BH8 4NO0 4NO2
Enriched GO Terms of Interacting Partners?		Protein Modification Process Positive Regulation Of Signal Transduction Post-translational Protein Modification Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein K48-linked Deubiquitination RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Protein Metabolic Process Regulation Of Mitotic Cell Cycle Enzyme Binding Regulation Of Primary Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Phosphatase Activity Positive Regulation Of Catabolic Process Cellular Response To Stress Regulation Of Intracellular Signal Transduction Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Process Protein Ubiquitination Cul4A-RING E3 Ubiquitin Ligase Complex Protein Catabolic Process Telomere Maintenance Via Telomere Trimming Negative Regulation Of Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Macromolecule Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Mesenchymal Cell Differentiation Protein Polyubiquitination Response To Stress Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Autoubiquitination Negative Regulation Of Signal Transduction Negative Regulation Of Calcium-mediated Signaling Regulation Of Cell Cycle Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Phosphoprotein Phosphatase Activity Cytoplasm Negative Regulation Of Cell Communication
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