SNAI1 and RCOR1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method)

		SNAI1	RCOR1
Description		snail family transcriptional repressor 1	REST corepressor 1
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Pericentric Heterochromatin Cytoplasm Cytosol	Histone Deacetylase Complex Nucleus Nucleoplasm Transcription Regulator Complex Transcription Repressor Complex Histone Methyltransferase Complex DNA Repair Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Kinase Binding Sequence-specific DNA Binding Metal Ion Binding E-box Binding Sequence-specific Double-stranded DNA Binding	Chromatin Binding Transcription Corepressor Activity Protein Binding Enzyme Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Mesoderm Formation Epithelial To Mesenchymal Transition Aortic Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Mesoderm Development Epithelial Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Cell Migration Hair Follicle Morphogenesis Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Mesenchymal Cell Differentiation Roof Of Mouth Development Canonical Wnt Signaling Pathway Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Left/right Pattern Formation Heterochromatin Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Bicellular Tight Junction Assembly	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Erythrocyte Differentiation Positive Regulation Of Megakaryocyte Differentiation Negative Regulation Of DNA-templated Transcription
Pathways		Regulation of PTEN gene transcription Regulation of PTEN gene transcription Epithelial-Mesenchymal Transition (EMT) during gastrulation Regulation of CDH11 gene transcription Negative Regulation of CDH1 Gene Transcription	HDACs deacetylate histones Regulation of PTEN gene transcription Potential therapeutics for SARS Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Psoriasis ( 20953189)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059) Body mass index ( 26426971) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Homeostasis model assessment of insulin resistance ( 33381925) Immature fraction of reticulocytes ( 27863252 32888494) LDL cholesterol levels in HIV infection ( 33109212) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Multiple sclerosis ( 31604244) Platelet count ( 27863252 22139419 32888494) Plateletcrit ( 27863252 32888494) Tinnitus ( 33742053)
Interacting Genes		49 interacting genes: ACTN2 ACTN3 BRMS1 COG6 CREBBP CTDSP1 CTDSP2 CTDSPL DDB1 EFHC1 EIF3H EXOSC8 FBXO22 FBXO45 FHL2 GLMN GOLGA6L9 GSK3B HOXD4 KPNB1 KRT31 KRT40 KRTAP1-1 KRTAP10-3 LATS2 LSP1 MFHAS1 MID2 MTA1 MTUS2 NBN NOTCH1 NOTCH2NLA OTUB1 PALB2 PAX2 PFDN5 PPIL2 PTEN PTPN1 RBX1 RCOR1 TGFB1 TNFAIP3 TRAF2 TRIM23 TRIP6 USP29 XRCC3	14 interacting genes: CEBPA FOXK2 GFI1B H3-4 HDAC2 KDM1A PHF21A REST SMARCE1 SNAI1 SUB1 SUMO2 UBC ZNF750
Entrez ID		6615	23186
HPRD ID		05025	09645
Ensembl ID		ENSG00000124216	ENSG00000089902
Uniprot IDs		O95863	Q9UKL0
PDB IDs		2Y48 3W5K 3ZMT 4QLI 8BOX 8F59 8FDV 8FJ7	2IW5 2UXN 2UXX 2V1D 2X0L 2XAF 2XAG 2XAH 2XAJ 2XAQ 2XAS 2Y48 3ZMS 3ZMT 3ZMU 3ZMV 3ZMZ 3ZN0 3ZN1 4BAY 4KUM 4UV8 4UV9 4UVA 4UVB 4UVC 4UXN 4XBF 5H6Q 5H6R 5L3B 5L3C 5L3D 5L3E 5L3F 5L3G 5LBQ 5LGN 5LGT 5LGU 5LHG 5LHH 5LHI 5X60 5YJB 6K3E 6KGK 6KGL 6KGM 6KGN 6S35 6TE1 6TUY 6VYP 6W4K 6WC6 7CDC 7CDD 7CDE 7CDF 7CDG 7ZRY 8BOP 8BOX 8F2Z 8F30 8F59 8F6S 8FDV 8FJ4 8FJ7 8FQJ 8FRI 8FRQ 8FRV 8FSK 8GJ6 8JF5 8Q1G 8Q1H 8Q1J 8UL6 8UL8 8ULB 8ULC 8UMQ 8UNI 8UOM 8VOJ 8VPQ 8VRT 8YM7 9DTQ 9DWU 9EL7 9EL8 9ELA 9FWG
Enriched GO Terms of Interacting Partners?		Protein Modification Process Positive Regulation Of Signal Transduction Post-translational Protein Modification Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein K48-linked Deubiquitination RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Protein Metabolic Process Regulation Of Mitotic Cell Cycle Enzyme Binding Regulation Of Primary Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Phosphatase Activity Positive Regulation Of Catabolic Process Cellular Response To Stress Regulation Of Intracellular Signal Transduction Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Process Protein Ubiquitination Cul4A-RING E3 Ubiquitin Ligase Complex Protein Catabolic Process Telomere Maintenance Via Telomere Trimming Negative Regulation Of Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Macromolecule Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Mesenchymal Cell Differentiation Protein Polyubiquitination Response To Stress Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Autoubiquitination Negative Regulation Of Signal Transduction Negative Regulation Of Calcium-mediated Signaling Regulation Of Cell Cycle Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Phosphoprotein Phosphatase Activity Cytoplasm Negative Regulation Of Cell Communication	Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin Organization Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Metabolic Process Regulation Of Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Negative Regulation Of Biosynthetic Process Chromatin Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding Positive Regulation Of Stem Cell Population Maintenance Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Epithelial To Mesenchymal Transition Regulation Of Developmental Process Promoter-specific Chromatin Binding Regulation Of Cell Development Regulation Of Stem Cell Population Maintenance Transcription Regulator Complex Positive Regulation Of Cell Differentiation Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Repair Complex Protein Tag Activity Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Chromatin Remodeling Regulation Of Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?