SNAI1 and GLMN

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SNAI1	GLMN
Description		snail family transcriptional repressor 1	glomulin, FKBP associated protein
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Pericentric Heterochromatin Cytoplasm Cytosol	Cytoplasm Cullin-RING Ubiquitin Ligase Complex Cul2-RING Ubiquitin Ligase Complex Cul3-RING Ubiquitin Ligase Complex Cul4A-RING E3 Ubiquitin Ligase Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Kinase Binding Sequence-specific DNA Binding Metal Ion Binding E-box Binding Sequence-specific Double-stranded DNA Binding	Signaling Receptor Binding Hepatocyte Growth Factor Receptor Binding Protein Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Mesoderm Formation Epithelial To Mesenchymal Transition Aortic Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Mesoderm Development Epithelial Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Cell Migration Hair Follicle Morphogenesis Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Mesenchymal Cell Differentiation Roof Of Mouth Development Canonical Wnt Signaling Pathway Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Left/right Pattern Formation Heterochromatin Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Bicellular Tight Junction Assembly	Vasculogenesis Positive Regulation Of Cytokine Production Neural Tube Closure Cell Surface Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Interleukin-2 Production Epigenetic Regulation Of Gene Expression Negative Regulation Of T Cell Proliferation Positive Regulation Of Phosphorylation Muscle Cell Differentiation Circulatory System Development
Pathways		Regulation of PTEN gene transcription Regulation of PTEN gene transcription Epithelial-Mesenchymal Transition (EMT) during gastrulation Regulation of CDH11 gene transcription Negative Regulation of CDH1 Gene Transcription	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases			Venous malformations, including: Sporadic venous malformation; Cutaneomucosal venous malformation; Glomuvenous malformation
GWAS		Psoriasis ( 20953189)	Granulocyte percentage of myeloid white cells ( 27863252) Lymphocyte percentage of white cells ( 27863252) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Myeloid white cell count ( 27863252)
Interacting Genes		49 interacting genes: ACTN2 ACTN3 BRMS1 COG6 CREBBP CTDSP1 CTDSP2 CTDSPL DDB1 EFHC1 EIF3H EXOSC8 FBXO22 FBXO45 FHL2 GLMN GOLGA6L9 GSK3B HOXD4 KPNB1 KRT31 KRT40 KRTAP1-1 KRTAP10-3 LATS2 LSP1 MFHAS1 MID2 MTA1 MTUS2 NBN NOTCH1 NOTCH2NLA OTUB1 PALB2 PAX2 PFDN5 PPIL2 PTEN PTPN1 RBX1 RCOR1 TGFB1 TNFAIP3 TRAF2 TRIM23 TRIP6 USP29 XRCC3	17 interacting genes: BIRC2 BIRC3 EFS FBXW7 FKBP1A FKBP4 HSPB1 MET NSFL1C OGT PEX5 PPDPF PRDM16 RBX1 RNF7 SKP1 SNAI1
Entrez ID		6615	11146
HPRD ID		05025	03451
Ensembl ID		ENSG00000124216	ENSG00000174842
Uniprot IDs		O95863	B4DJ85 Q92990
PDB IDs		2Y48 3W5K 3ZMT 4QLI 8BOX 8F59 8FDV 8FJ7	4F52
Enriched GO Terms of Interacting Partners?		Protein Modification Process Positive Regulation Of Signal Transduction Post-translational Protein Modification Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein K48-linked Deubiquitination RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Protein Metabolic Process Regulation Of Mitotic Cell Cycle Enzyme Binding Regulation Of Primary Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Phosphatase Activity Positive Regulation Of Catabolic Process Cellular Response To Stress Regulation Of Intracellular Signal Transduction Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Process Protein Ubiquitination Cul4A-RING E3 Ubiquitin Ligase Complex Protein Catabolic Process Telomere Maintenance Via Telomere Trimming Negative Regulation Of Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Macromolecule Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Mesenchymal Cell Differentiation Protein Polyubiquitination Response To Stress Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Autoubiquitination Negative Regulation Of Signal Transduction Negative Regulation Of Calcium-mediated Signaling Regulation Of Cell Cycle Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Phosphoprotein Phosphatase Activity Cytoplasm Negative Regulation Of Cell Communication	Regulation Of Programmed Cell Death Regulation Of Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Necroptotic Process Regulation Of Post-translational Protein Modification Intracellular Signal Transduction Ubiquitin Binding Positive Regulation Of Protein Ubiquitination Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Cullin Family Protein Binding SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Cul7-RING Ubiquitin Ligase Complex NEDD8 Ligase Activity Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Post-translational Protein Modification Negative Regulation Of Protein-containing Complex Assembly NEDD8 Transferase Activity Modification-dependent Protein Catabolic Process Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Catabolic Process Cytosol Protein Monoubiquitination Regulation Of Signal Transduction Regulation Of Protein Modification Process SCF Ubiquitin Ligase Complex Negative Regulation Of Proteasomal Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling Protein Modification By Small Protein Conjugation Negative Regulation Of Cellular Component Organization Regulation Of Intracellular Signal Transduction FK506 Binding Regulation Of Protein-containing Complex Assembly Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein-containing Complex Heterochromatin Organization Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Cell Communication Cytoplasm Regulation Of Signaling Proteolysis Epithelial To Mesenchymal Transition
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