SNAI1 and FBXO22

Number of citations of the paper that reports this interaction (PubMedID 29945959)
0

Data Source:
BioGRID (enzymatic study)

		SNAI1	FBXO22
Description		snail family transcriptional repressor 1	F-box protein 22
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Pericentric Heterochromatin Cytoplasm Cytosol	Nucleus Cytoplasm Cytosol Z Disc
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Kinase Binding Sequence-specific DNA Binding Metal Ion Binding E-box Binding Sequence-specific Double-stranded DNA Binding	Ubiquitin-protein Transferase Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Mesoderm Formation Epithelial To Mesenchymal Transition Aortic Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Mesoderm Development Epithelial Cell Migration Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Cell Migration Hair Follicle Morphogenesis Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Mesenchymal Cell Differentiation Roof Of Mouth Development Canonical Wnt Signaling Pathway Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Left/right Pattern Formation Heterochromatin Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Bicellular Tight Junction Assembly	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Nucleocytoplasmic Transport Cellular Response To Starvation Regulation Of Myotube Differentiation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Modification Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Skeletal Muscle Fiber Development Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Pathways		Regulation of PTEN gene transcription Regulation of PTEN gene transcription Epithelial-Mesenchymal Transition (EMT) during gastrulation Regulation of CDH11 gene transcription Negative Regulation of CDH1 Gene Transcription	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Psoriasis ( 20953189)	Creatinine levels ( 29403010) Urate levels in obese individuals ( 25811787)
Interacting Genes		49 interacting genes: ACTN2 ACTN3 BRMS1 COG6 CREBBP CTDSP1 CTDSP2 CTDSPL DDB1 EFHC1 EIF3H EXOSC8 FBXO22 FBXO45 FHL2 GLMN GOLGA6L9 GSK3B HOXD4 KPNB1 KRT31 KRT40 KRTAP1-1 KRTAP10-3 LATS2 LSP1 MFHAS1 MID2 MTA1 MTUS2 NBN NOTCH1 NOTCH2NLA OTUB1 PALB2 PAX2 PFDN5 PPIL2 PTEN PTPN1 RBX1 RCOR1 TGFB1 TNFAIP3 TRAF2 TRIM23 TRIP6 USP29 XRCC3	1 interacting genes: SNAI1
Entrez ID		6615	26263
HPRD ID		05025	16437
Ensembl ID		ENSG00000124216	ENSG00000167196
Uniprot IDs		O95863	Q8NEZ5
PDB IDs		2Y48 3W5K 3ZMT 4QLI 8BOX 8F59 8FDV 8FJ7	8S7D 8S7E 8UA3 8UA6
Enriched GO Terms of Interacting Partners?		Protein Modification Process Positive Regulation Of Signal Transduction Post-translational Protein Modification Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein K48-linked Deubiquitination RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Protein Metabolic Process Regulation Of Mitotic Cell Cycle Enzyme Binding Regulation Of Primary Metabolic Process Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Phosphatase Activity Positive Regulation Of Catabolic Process Cellular Response To Stress Regulation Of Intracellular Signal Transduction Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Communication Regulation Of Signaling Regulation Of Apoptotic Process Protein Ubiquitination Cul4A-RING E3 Ubiquitin Ligase Complex Protein Catabolic Process Telomere Maintenance Via Telomere Trimming Negative Regulation Of Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Macromolecule Metabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Mesenchymal Cell Differentiation Protein Polyubiquitination Response To Stress Protein Modification By Small Protein Conjugation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Autoubiquitination Negative Regulation Of Signal Transduction Negative Regulation Of Calcium-mediated Signaling Regulation Of Cell Cycle Phase Transition Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle G1/S Phase Transition Phosphoprotein Phosphatase Activity Cytoplasm Negative Regulation Of Cell Communication	Left/right Pattern Formation Central Tolerance Induction Positive Regulation Of Lung Ciliated Cell Differentiation Glomerular Parietal Epithelial Cell Development Positive Regulation Of B Cell Tolerance Induction Positive Regulation Of Central B Cell Tolerance Induction Negative Regulation Of Germinal Center Formation Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Platelet-derived Growth Factor Production Regulation Of Platelet-derived Growth Factor Production Metanephric Part Of Ureteric Bud Development Regionalization Negative Regulation Of Vitamin D Biosynthetic Process Ciliary Basal Body Organization Positive Regulation Of Multicellular Organismal Process Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Glomerular Mesangial Cell Proliferation Regulation Of Germinal Center Formation Pattern Specification Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Cartilage Morphogenesis Regulation Of Vitamin Metabolic Process Positive Regulation Of Cell Proliferation Involved In Kidney Development Positive Regulation Of Tolerance Induction Sequence-specific DNA Binding Heterochromatin Organization Regulation Of Glomerular Mesangial Cell Proliferation Lung Epithelium Development Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Trophoblast Giant Cell Differentiation Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Tolerance Induction Tolerance Induction Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Biosynthetic Process Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Regulation Of T Cell Differentiation In Thymus Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Bicellular Tight Junction Assembly Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of Steroid Biosynthetic Process Negative Regulation Of Cell Differentiation Negative Regulation Of Steroid Metabolic Process Cardiac Epithelial To Mesenchymal Transition
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