EIF3B and EIF4G1

Number of citations of the paper that reports this interaction (PMID 16541103)
31

Data Source:
HPRD (in vivo)

		EIF3B	EIF4G1
Gene Name		eukaryotic translation initiation factor 3, subunit B	eukaryotic translation initiation factor 4 gamma, 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex Extracellular Vesicular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3m	Cytosol Membrane Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	Nucleotide Binding Translation Initiation Factor Activity Protein Binding Translation Initiation Factor Binding Protein Complex Scaffold	Translation Initiation Factor Activity Protein Binding Translation Factor Activity, Nucleic Acid Binding Poly(A) RNA Binding
	Biological Process	Formation Of Translation Preinitiation Complex Translation Translational Initiation Regulation Of Translational Initiation Gene Expression Cellular Protein Metabolic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Translation Translational Initiation Regulation Of Translational Initiation Insulin Receptor Signaling Pathway Gene Expression Viral Process Cytokine-mediated Signaling Pathway Cellular Protein Metabolic Process
Pathways		Ribosomal scanning and start codon recognition Translation initiation complex formation Formation of the ternary complex, and subsequently, the 43S complex GTP hydrolysis and joining of the 60S ribosomal subunit Translation Eukaryotic Translation Initiation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Formation of a pool of free 40S subunits Cap-dependent Translation Initiation L13a-mediated translational silencing of Ceruloplasmin expression	Translation initiation complex formation IRS-mediated signalling mTOR signalling S6K1-mediated signalling mTOR signalling mTORC1-mediated signalling AUF1 (hnRNP D0) destabilizes mRNA IGF1R signaling cascade Deadenylation-dependent mRNA decay IRS-related events triggered by IGF1R Eukaryotic Translation Initiation S6K1 signalling Cap-dependent Translation Initiation PKB-mediated events PI3K Cascade Signaling by Insulin receptor Nonsense-Mediated Decay (NMD) Regulation of mRNA stability by proteins that bind AU-rich elements Insulin receptor signalling cascade Deadenylation of mRNA Translation ISG15 antiviral mechanism Interferon Signaling S6K1 signalling Cytokine Signaling in Immune system IRS-related events L13a-mediated translational silencing of Ceruloplasmin expression S6K1-mediated signalling Antiviral mechanism by IFN-stimulated genes mTORC1-mediated signalling Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S PKB-mediated events PI3K Cascade Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: BRCA1 EIF3A EIF3G EIF3I EIF3J EIF4G1 IL2RB UPF1	24 interactors: ANXA5 CENPU EIF3A EIF3B EIF3I EIF4A1 EIF4A2 EIF4E EIF5 GK HNRNPD HSPB1 HTRA2 MKNK1 MKNK2 NCBP1 NCBP2 PABPC1 PAK2 PDCD4 TRAF2 UBE3A UPF2 ZFYVE9
Entrez ID		8662	1981
HPRD ID		06795	06774
Ensembl ID		ENSG00000106263	ENSG00000114867
Uniprot IDs		P55884	B2RU06 B2RU10 B4DSI9 E7EUU4 E7EX73 E9PGM1 O95065 Q04637 Q96I65
PDB IDs		2KRB 2NLW	1LJ2 1UG3 2W97 4F02
Enriched GO Terms of Interacting Partners?		Regulation Of Translational Initiation Formation Of Translation Preinitiation Complex Regulation Of Translation Posttranscriptional Regulation Of Gene Expression Translational Initiation Ribonucleoprotein Complex Assembly Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Translation Dosage Compensation By Inactivation Of X Chromosome Ribonucleoprotein Complex Biogenesis Dosage Compensation Cytoplasmic Translation Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Macromolecular Complex Assembly Biosynthetic Process Regulation Of Gene Expression Cellular Component Assembly Gene Expression Positive Regulation Of Histone H4-K20 Methylation Positive Regulation Of Histone H4-K16 Acetylation Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Positive Regulation Of Histone H3-K9 Acetylation Nuclear Export Cellular Protein Metabolic Process Cellular Response To Cytokine Stimulus Positive Regulation Of Histone H4 Acetylation Negative Regulation Of Histone H3-K4 Methylation Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Interleukin-2-mediated Signaling Pathway Response To Cytokine RNA Catabolic Process Formation Of Cytoplasmic Translation Initiation Complex Cellular Response To Indole-3-methanol Regulation Of Metabolic Process Negative Regulation Of Centriole Replication Regulation Of Gene Expression, Epigenetic Protein K6-linked Ubiquitination Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Mature Ribosome Assembly Regulation Of Histone H3-K9 Acetylation Protein Metabolic Process Ribosomal Subunit Export From Nucleus Histone MRNA Catabolic Process Nucleocytoplasmic Transport Cytoplasmic Translational Initiation Nuclear Transport	Regulation Of Translation Regulation Of Translational Initiation Posttranscriptional Regulation Of Gene Expression Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process RNA Catabolic Process Translational Initiation Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA 3'-end Processing RNA 3'-end Processing Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Metabolic Process Catabolic Process Viral Process Cellular Macromolecular Complex Assembly Nuclear Export MRNA Processing Regulation Of Gene Expression Translation Nucleocytoplasmic Transport Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear Transport Regulation Of Metabolic Process MRNA Export From Nucleus Ribonucleoprotein Complex Assembly Gene Expression RNA Export From Nucleus RNA Processing Formation Of Translation Preinitiation Complex Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Transport RNA Transport Cellular Protein Metabolic Process RNA Localization Ribonucleoprotein Complex Biogenesis Regulation Of Cellular Process Gene Silencing By RNA Protein Metabolic Process Cytoplasmic Transport Cellular Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process MRNA Cis Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of MRNA 3'-end Processing
Tagcloud ?		attenuation b3 cardiovirulence coxsackievirus cvb3 decisive diagnomx diagnosticpathology eif4b eif4g eu extrapolating ires myocarditis neurovirulence organized p116 p220 p80 playing poliovirus reinforce ribosome sabin sabin3 slide u473 virtual www	bioinformatics box burkitt cacgtgt carrying cdk4 chip compelling consensus consequently copyright imidazole interesting k562 leukaemia myc myelogenous owing p493 pi polyamide promoters protected pyrrole qpcr rationale recognizes reserved rights
Tagcloud (Difference) ?		attenuation b3 cardiovirulence coxsackievirus cvb3 decisive diagnomx diagnosticpathology eif4b eif4g eu extrapolating ires myocarditis neurovirulence organized p116 p220 p80 playing poliovirus reinforce ribosome sabin sabin3 slide u473 virtual www	bioinformatics box burkitt cacgtgt carrying cdk4 chip compelling consensus consequently copyright imidazole interesting k562 leukaemia myc myelogenous owing p493 pi polyamide promoters protected pyrrole qpcr rationale recognizes reserved rights
Tagcloud (Intersection) ?